SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 MET A  15
ALA A  33
PHE A  52
LEU A  72
LEU A  26
None
1.39A 1eiiA-6f2cA:
undetectable
1eiiA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 ILE A  76
LEU A  72
HIS A   8
LEU A 105
ILE A 103
None
None
GOL  A 202 (-4.1A)
None
None
1.01A 1fmlB-6f2cA:
2.3
1fmlB-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
4 / 7 LEU A  78
GLU A 113
ALA A 106
LEU A  74
None
1.10A 1sn0B-6f2cA:
undetectable
1sn0D-6f2cA:
undetectable
1sn0B-6f2cA:
17.29
1sn0D-6f2cA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 LEU A   5
LEU A 105
ALA A 106
LEU A 119
THR A  19
None
1.33A 2oaxB-6f2cA:
undetectable
2oaxB-6f2cA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 11 MET A 109
ALA A 106
LEU A  74
LEU A   5
ILE A  25
None
1.32A 3jw5A-6f2cA:
undetectable
3jw5A-6f2cA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 10 ILE A   6
ILE A  41
GLY A  38
GLY A  35
MET A  15
None
None
None
GOL  A 201 (-3.3A)
None
0.98A 4fakA-6f2cA:
undetectable
4fakA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 10 LEU A   5
ILE A  41
GLY A  38
GLY A  35
MET A  15
None
None
None
GOL  A 201 (-3.3A)
None
0.82A 4fakA-6f2cA:
undetectable
4fakA-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
None
1.06A 4fp9A-6f2cA:
2.2
4fp9A-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
None
1.03A 4fp9C-6f2cA:
2.1
4fp9C-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 CYH A  98
LEU A  72
GLY A  64
ASP A  99
LEU A  94
None
0.99A 4fp9F-6f2cA:
2.2
4fp9F-6f2cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 LEU A   5
GLY A  38
LEU A  47
ILE A  63
PHE A  52
None
1.13A 4p6xA-6f2cA:
undetectable
4p6xA-6f2cA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 12 LEU A   5
GLY A  38
LEU A  47
ILE A  63
PHE A  52
None
1.09A 4p6xE-6f2cA:
undetectable
4p6xE-6f2cA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
6f2c METHYLGLYOXAL
SYNTHASE

(Bacillus
subtilis)
5 / 11 GLY A  59
GLY A  55
ASP A  60
LEU A  94
VAL A  91
None
CL  A 203 (-4.1A)
None
None
None
1.13A 4pghA-6f2cA:
3.0
4pghA-6f2cA:
undetectable