SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 6f2t -
(-) 		4 / 7 ASP A 326
ASP A 168
TYR A 174
ARG A 171
 ZN  A1003 ( 2.1A)
ZN  A1002 (-2.0A)
None
None
 1.47A 1cebA-6f2tA:
undetectable		 1cebA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 6f2t -
(-) 		5 / 5 THR A 206
ASP A 326
HIS A 330
HIS A 374
HIS A 483
 ZN  A1002 ( 2.5A)
ZN  A1003 ( 2.1A)
ZN  A1003 (-3.2A)
ZN  A1002 (-3.1A)
ZN  A1003 ( 3.1A)
 0.54A 1ei6A-6f2tA:
26.9		 1ei6A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 6f2t -
(-) 		6 / 8 ASP A 168
THR A 206
ASP A 326
HIS A 330
HIS A 374
HIS A 483
 ZN  A1002 (-2.0A)
ZN  A1002 ( 2.5A)
ZN  A1003 ( 2.1A)
ZN  A1003 (-3.2A)
ZN  A1002 (-3.1A)
ZN  A1003 ( 3.1A)
 0.50A 1ei6C-6f2tA:
4.5		 1ei6C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 6f2t -
(-) 		4 / 8 THR A 206
ASP A 326
HIS A 330
HIS A 483
 ZN  A1002 ( 2.5A)
ZN  A1003 ( 2.1A)
ZN  A1003 (-3.2A)
ZN  A1003 ( 3.1A)
 0.50A 1ei6D-6f2tA:
27.3		 1ei6D-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 6f2t -
(-) 		3 / 3 TRP A 251
VAL A 243
TRP A 250
 None
 1.38A 1gmkC-6f2tA:
undetectable
1gmkD-6f2tA:
undetectable		 1gmkC-6f2tA:
undetectable
1gmkD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 6f2t -
(-) 		4 / 4 ALA A 172
ARG A 171
GLN A 176
GLU A 173
 None
 1.36A 1lqtB-6f2tA:
undetectable		 1lqtB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 6f2t -
(-) 		4 / 4 ALA A 172
ARG A 171
GLN A 176
GLU A 173
 None
 1.37A 1lquB-6f2tA:
undetectable		 1lquB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6f2t -
(-) 		4 / 6 LEU A 353
PHE A 350
ALA A 349
LEU A 303
 None
 0.89A 1ukbA-6f2tA:
undetectable		 1ukbA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 6f2t -
(-) 		5 / 10 SER A 380
GLY A 480
SER A 332
SER A 336
GLN A 466
 None
 1.46A 2c2bA-6f2tA:
undetectable
2c2bB-6f2tA:
undetectable		 2c2bA-6f2tA:
undetectable
2c2bB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 6f2t -
(-) 		5 / 10 SER A 380
GLY A 480
SER A 332
SER A 336
GLN A 466
 None
 1.44A 2c2bC-6f2tA:
1.8
2c2bD-6f2tA:
undetectable		 2c2bC-6f2tA:
undetectable
2c2bD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 6f2t -
(-) 		5 / 11 SER A 380
GLY A 480
SER A 332
SER A 336
GLN A 466
 None
 1.50A 2c2bE-6f2tA:
undetectable
2c2bF-6f2tA:
undetectable		 2c2bE-6f2tA:
undetectable
2c2bF-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 6f2t -
(-) 		5 / 10 GLN A 466
SER A 380
GLY A 480
SER A 332
SER A 336
 None
 1.45A 2c2bE-6f2tA:
undetectable
2c2bF-6f2tA:
1.8		 2c2bE-6f2tA:
undetectable
2c2bF-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 6f2t -
(-) 		4 / 6 LEU A 733
GLU A 739
ILE A 738
PRO A 651
 None
 1.11A 2fcnA-6f2tA:
undetectable
2fcnB-6f2tA:
undetectable		 2fcnA-6f2tA:
undetectable
2fcnB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 6f2t -
(-) 		4 / 8 TYR A 485
TYR A 174
HIS A 330
GLY A 329
 None
None
ZN  A1003 (-3.2A)
None
 1.03A 2ha4A-6f2tA:
undetectable		 2ha4A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 6f2t -
(-) 		5 / 12 ALA A 498
GLY A 500
MET A 354
GLY A 356
LEU A 357
 None
 0.98A 2hw2A-6f2tA:
undetectable		 2hw2A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 6f2t -
(-) 		5 / 10 SER A 632
ILE A 710
ASN A 590
LEU A 593
ASN A 594
 None
 1.15A 2nnhB-6f2tA:
undetectable		 2nnhB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 6f2t -
(-) 		4 / 4 SER A 557
GLY A 633
GLY A 635
LYS A 636
 None
 1.28A 2y4nB-6f2tA:
undetectable		 2y4nB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.05A 2zj0A-6f2tA:
undetectable		 2zj0A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.13A 2zj0B-6f2tA:
undetectable		 2zj0B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 6f2t -
(-) 		3 / 3 GLY A 480
GLY A 329
GLY A 333
 None
 0.42A 3bogD-6f2tA:
undetectable		 3bogD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.11A 3ce6A-6f2tA:
undetectable		 3ce6A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.11A 3ce6B-6f2tA:
undetectable		 3ce6B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.11A 3ce6C-6f2tA:
undetectable		 3ce6C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 6f2t -
(-) 		3 / 3 ARG A 592
VAL A 631
THR A 603
 None
 0.53A 3cyxA-6f2tA:
undetectable		 3cyxA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 6f2t -
(-) 		6 / 12 GLY A 216
ASN A 533
ILE A 256
ASN A 514
LEU A 217
THR A 319
 None
NAG  A1010 (-1.9A)
None
None
None
None
 1.40A 3eeyC-6f2tA:
undetectable		 3eeyC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.45A 3fhjD-6f2tA:
undetectable		 3fhjD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.45A 3fhjF-6f2tA:
undetectable		 3fhjF-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.46A 3fi0D-6f2tA:
undetectable		 3fi0D-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.44A 3fi0F-6f2tA:
undetectable		 3fi0F-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 ASP A 689
ILE A 688
VAL A 769
VAL A 774
GLN A 677
 None
 1.21A 3fi0H-6f2tA:
undetectable		 3fi0H-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 ASP A 689
ILE A 688
VAL A 769
VAL A 774
GLN A 677
 None
 1.27A 3fi0J-6f2tA:
undetectable		 3fi0J-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 ASP A 689
ILE A 688
VAL A 769
VAL A 774
GLN A 677
 None
 1.26A 3fi0K-6f2tA:
undetectable		 3fi0K-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 ASP A 689
ILE A 688
VAL A 769
VAL A 774
GLN A 677
 None
 1.27A 3fi0L-6f2tA:
undetectable		 3fi0L-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.47A 3fi0L-6f2tA:
undetectable		 3fi0L-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f2t -
(-) 		5 / 9 HIS A 690
ASP A 689
ILE A 688
VAL A 774
GLN A 677
 None
 1.43A 3fi0R-6f2tA:
undetectable		 3fi0R-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6f2t -
(-) 		5 / 12 ILE A 515
GLY A 216
ILE A 213
ILE A 256
VAL A 201
 None
 0.92A 3fpjA-6f2tA:
undetectable		 3fpjA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 378
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.50A 3glqB-6f2tA:
undetectable		 3glqB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.14A 3glqB-6f2tA:
undetectable		 3glqB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.14A 3n58A-6f2tA:
undetectable		 3n58A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 6f2t -
(-) 		4 / 7 THR A 206
ASP A 326
HIS A 330
HIS A 483
 ZN  A1002 ( 2.5A)
ZN  A1003 ( 2.1A)
ZN  A1003 (-3.2A)
ZN  A1003 ( 3.1A)
 0.48A 3t01A-6f2tA:
26.5		 3t01A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 6f2t -
(-) 		3 / 3 ARG A 407
ARG A 405
ILE A 411
 NAG  A1005 (-4.1A)
None
None
 0.79A 4b7qA-6f2tA:
undetectable		 4b7qA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 6f2t -
(-) 		3 / 3 ARG A 407
ARG A 405
ILE A 411
 NAG  A1005 (-4.1A)
None
None
 0.68A 4b7qC-6f2tA:
undetectable		 4b7qC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 6f2t -
(-) 		4 / 8 GLU A 604
ASN A 596
GLY A 598
SER A 601
 None
 1.01A 4f93B-6f2tA:
undetectable		 4f93B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 6f2t -
(-) 		5 / 12 LEU A 345
GLY A 333
GLY A 329
ALA A 342
GLY A 375
 None
 1.00A 4n09B-6f2tA:
undetectable		 4n09B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f2t -
(-) 		3 / 3 ILE A 411
ASP A 457
ARG A 409
 None
 0.77A 4pstA-6f2tA:
undetectable		 4pstA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6f2t -
(-) 		3 / 3 SER A 632
TYR A 630
ASP A 668
 None
 0.83A 4rp8C-6f2tA:
undetectable		 4rp8C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6f2t -
(-) 		4 / 7 PRO A 208
SER A 242
PHE A 238
ASP A 226
 None
 1.31A 5a1iA-6f2tA:
undetectable		 5a1iA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 6f2t -
(-) 		5 / 12 ASP A 168
THR A 206
PHE A 207
PRO A 255
ARG A 299
 ZN  A1002 (-2.0A)
ZN  A1002 ( 2.5A)
None
None
None
 0.80A 5dlvA-6f2tA:
52.2		 5dlvA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 6f2t -
(-) 		6 / 12 ASP A 168
THR A 206
PHE A 207
PRO A 255
TRP A 257
ARG A 299
 ZN  A1002 (-2.0A)
ZN  A1002 ( 2.5A)
None
None
None
None
 0.83A 5dlvB-6f2tA:
52.3		 5dlvB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6f2t -
(-) 		5 / 9 GLY A 563
GLN A 588
ASN A 590
LEU A 593
LEU A 625
 None
 1.25A 5fhzB-6f2tA:
undetectable		 5fhzB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6f2t -
(-) 		5 / 10 GLY A 563
GLN A 588
ASN A 590
LEU A 593
LEU A 625
 None
 1.29A 5fhzC-6f2tA:
undetectable		 5fhzC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 6f2t -
(-) 		3 / 3 MET A 376
HIS A 330
GLY A 484
 None
ZN  A1003 (-3.2A)
None
 0.88A 5gwzB-6f2tA:
undetectable		 5gwzB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 6f2t -
(-) 		4 / 7 ASP A 326
ASP A 373
GLY A 375
TYR A 174
 ZN  A1003 ( 2.1A)
ZN  A1002 (-2.4A)
None
None
 1.13A 5hwaA-6f2tA:
undetectable		 5hwaA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 6f2t -
(-) 		5 / 11 ASP A 168
SER A 166
ASP A 326
TYR A 321
SER A 269
 ZN  A1002 (-2.0A)
None
ZN  A1003 ( 2.1A)
None
None
 1.17A 5iqeA-6f2tA:
undetectable		 5iqeA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 6f2t -
(-) 		5 / 12 ASP A 168
SER A 166
ASP A 326
TYR A 321
SER A 269
 ZN  A1002 (-2.0A)
None
ZN  A1003 ( 2.1A)
None
None
 1.16A 5iqeC-6f2tA:
undetectable		 5iqeC-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 6f2t -
(-) 		5 / 12 ASP A 168
SER A 166
ASP A 326
TYR A 321
SER A 269
 ZN  A1002 (-2.0A)
None
ZN  A1003 ( 2.1A)
None
None
 1.22A 5iqeD-6f2tA:
undetectable		 5iqeD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6f2t -
(-) 		4 / 4 LEU A 175
ARG A 171
ILE A 495
PHE A 170
 None
 1.16A 5kirB-6f2tA:
undetectable		 5kirB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 6f2t -
(-) 		4 / 6 PRO A 550
PRO A 546
PHE A 547
LEU A 543
 None
 0.96A 5tl8A-6f2tA:
undetectable		 5tl8A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 6f2t -
(-) 		5 / 9 ASP A 377
GLY A 481
GLY A 333
ALA A 328
VAL A 339
 None
 1.36A 5v3cA-6f2tA:
undetectable		 5v3cA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 6f2t -
(-) 		5 / 12 VAL A 774
GLY A 691
PRO A 777
VAL A 776
VAL A 769
 None
 1.06A 6dh0B-6f2tA:
undetectable		 6dh0B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6f2t -
(-) 		4 / 7 PRO A 208
SER A 242
PHE A 238
ASP A 226
 None
 1.33A 6g6rA-6f2tA:
undetectable		 6g6rA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 6f2t -
(-) 		4 / 5 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.17A 6gbnB-6f2tA:
2.1		 6gbnB-6f2tA:
undetectable