SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 ALA A  25
LEU A 128
GLY A  22
PHE A  21
LEU A  54
 None
None
NAP  A 401 (-3.4A)
None
None
 1.05A 1qabF-6f2uA:
undetectable		 1qabF-6f2uA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 12 TYR A  24
LEU A  54
HIS A 117
GLU A 192
TYR A 216
SER A 217
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 0.71A 1s2aA-6f2uA:
52.3		 1s2aA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
SER A 118
GLU A 192
TYR A 216
SER A 217
GLN A 222
PHE A 306
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
NAP  A 401 (-3.8A)
CJ2  A 402 (-3.8A)
 0.45A 1s2aA-6f2uA:
52.3		 1s2aA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
SER A 118
MET A 120
GLU A 192
TYR A 216
SER A 217
GLN A 222
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
NAP  A 401 (-3.8A)
 0.36A 1s2aA-6f2uA:
52.3		 1s2aA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF0_A_ASDA600_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 9 LEU A  54
TRP A  86
ASN A 167
TRP A 227
PRO A 318
 None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
None
 1.22A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF0_A_ASDA600_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 9 LEU A  54
TRP A  86
MET A 120
ASN A 167
TYR A 216
PRO A 318
 None
None
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
 0.33A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF0_A_ASDA600_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 9 LEU A  54
TRP A  86
MET A 120
SER A 129
ASN A 167
PRO A 318
 None
None
CJ2  A 402 ( 4.7A)
None
NAP  A 401 ( 3.3A)
None
 0.62A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF0_A_ASDA600_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 9 LEU A  54
TRP A  86
SER A 129
ASN A 167
PHE A 306
 None
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
 1.41A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 TRP A  86
SER A 118
PHE A 311
PRO A 318
TYR A 317
 None
CJ2  A 402 ( 3.7A)
None
None
None
 1.39A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
TRP A  86
SER A 118
MET A 120
LEU A 122
SER A 129
ASN A 167
PHE A 306
PRO A 318
TYR A 319
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
None
None
 0.52A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
TRP A  86
SER A 118
MET A 120
LEU A 122
SER A 129
ASN A 167
PHE A 311
PRO A 318
TYR A 319
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
None
None
NAP  A 401 ( 3.3A)
None
None
None
 0.61A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		3 / 3 ASN A 189
TYR A 319
SER A 118
 None
None
CJ2  A 402 ( 3.7A)
 0.93A 2gvcB-6f2uA:
undetectable		 2gvcB-6f2uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 9 LEU A  85
GLY A 164
SER A  87
SER A 121
LEU A 144
 None
 1.14A 2qmmA-6f2uA:
undetectable		 2qmmA-6f2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 HIS A 117
ILE A 163
GLY A 164
VAL A 214
ASP A  12
 CJ2  A 402 ( 3.8A)
None
None
None
None
 1.04A 3bwcA-6f2uA:
undetectable		 3bwcA-6f2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_C_ACTC901_0
(PYRANOSE 2-OXIDASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 5 SER A 118
GLN A 172
HIS A 314
ASN A 316
 CJ2  A 402 ( 3.7A)
None
None
None
 1.46A 3lskC-6f2uA:
0.9		 3lskC-6f2uA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 12 LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 1.07A 3r43A-6f2uA:
51.5		 3r43A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A  87
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
None
 1.43A 3r43A-6f2uA:
51.5		 3r43A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TYR A 216
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
 0.55A 3r43A-6f2uA:
51.5		 3r43A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
MET A 120
ASN A 167
TYR A 216
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
 0.28A 3r43A-6f2uA:
51.5		 3r43A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 10 LEU A  54
TYR A  55
HIS A 117
ASN A 167
PHE A 306
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
None
None
 1.08A 3r58A-6f2uA:
50.2		 3r58A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 10 LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
TYR A 216
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
None
 0.37A 3r58A-6f2uA:
50.2		 3r58A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A  87
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
None
 1.47A 3r6iA-6f2uA:
50.4		 3r6iA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 12 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 1.04A 3r6iA-6f2uA:
50.4		 3r6iA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TYR A 216
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
 0.48A 3r6iA-6f2uA:
50.4		 3r6iA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
MET A 120
ASN A 167
TYR A 216
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
 0.27A 3r6iA-6f2uA:
50.4		 3r6iA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 10 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 1.03A 3r7mA-6f2uA:
50.3		 3r7mA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 10 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
 0.48A 3r7mA-6f2uA:
50.3		 3r7mA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 9 LEU A  54
TYR A  55
HIS A 117
ASN A 167
PHE A 306
PRO A 318
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
None
 1.06A 3r8gA-6f2uA:
50.5		 3r8gA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 9 LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
TYR A 216
PRO A 318
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
 0.34A 3r8gA-6f2uA:
50.5		 3r8gA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
None
None
 1.07A 3r94A-6f2uA:
50.2		 3r94A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TYR A 216
TRP A 227
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
None
None
 0.49A 3r94A-6f2uA:
50.2		 3r94A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 LEU A  54
TYR A  55
HIS A 117
SER A 118
MET A 120
ASN A 167
TYR A 216
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
None
 0.35A 3r94A-6f2uA:
50.2		 3r94A-6f2uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 NAP  A 401 ( 4.7A)
None
NAP  A 401 (-3.4A)
None
None
 0.94A 3rukA-6f2uA:
undetectable		 3rukA-6f2uA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 NAP  A 401 ( 4.7A)
None
NAP  A 401 (-3.4A)
None
None
 0.94A 3rukB-6f2uA:
undetectable		 3rukB-6f2uA:
10.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 LEU A  54
TRP A  86
MET A 120
SER A 217
PRO A 318
TYR A 319
 None
None
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 2.7A)
None
None
 1.14A 3ug8A-6f2uA:
50.6		 3ug8A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		11 / 12 LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
TYR A 216
SER A 217
SER A 221
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-4.6A)
None
None
 0.39A 3ug8A-6f2uA:
50.6		 3ug8A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TRP A  86
MET A 120
ASN A 167
TYR A 216
SER A 217
SER A 221
PHE A 306
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-4.6A)
CJ2  A 402 (-3.8A)
None
None
 0.72A 3ug8A-6f2uA:
50.6		 3ug8A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 TRP A  86
MET A 120
SER A 217
PHE A 306
PRO A 318
TYR A 319
 None
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-3.8A)
None
None
 1.08A 3ug8A-6f2uA:
50.6		 3ug8A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		3 / 3 TYR A  24
GLU A 192
TYR A 305
 CJ2  A 402 (-4.2A)
CJ2  A 402 ( 3.8A)
None
 0.23A 3ug8A-6f2uA:
50.6		 3ug8A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 12 TYR A  24
LEU A  54
HIS A 117
TYR A 216
SER A 217
SER A 221
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-4.6A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 0.76A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 TYR A  24
LEU A  54
SER A 217
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
NAP  A 401 ( 2.7A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 1.45A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
SER A 118
MET A 120
TYR A 216
SER A 217
SER A 221
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-4.6A)
 0.40A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
SER A 118
TYR A 216
SER A 217
SER A 221
PHE A 306
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.2A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-4.6A)
CJ2  A 402 (-3.8A)
 0.47A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TRP A  86
SER A 118
MET A 120
SER A 217
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 2.7A)
 1.04A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TRP A  86
SER A 118
SER A 217
PHE A 306
 CJ2  A 402 (-4.2A)
None
None
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 2.7A)
CJ2  A 402 (-3.8A)
 1.31A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 7 TYR A  55
ASN A 167
GLU A 192
GLN A 222
TYR A 305
PRO A 318
TYR A 319
 CJ2  A 402 ( 4.1A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 3.8A)
NAP  A 401 (-3.8A)
None
None
None
 0.37A 3ugrA-6f2uA:
51.1		 3ugrA-6f2uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 6 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A 401 (-3.4A)
None
None
 0.92A 4dtzB-6f2uA:
undetectable		 4dtzB-6f2uA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 7 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A 401 (-3.4A)
None
None
 0.89A 4du2A-6f2uA:
undetectable		 4du2A-6f2uA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 7 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A 401 (-3.4A)
None
None
 0.91A 4du2B-6f2uA:
undetectable		 4du2B-6f2uA:
9.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 10 TYR A  24
TYR A  55
HIS A 117
ASN A 167
TYR A 216
 CJ2  A 402 (-4.2A)
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
 0.28A 4jq4B-6f2uA:
50.5		 4jq4B-6f2uA:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 8 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 CJ2  A 402 (-4.2A)
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
 0.19A 4jtrA-6f2uA:
51.5		 4jtrA-6f2uA:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 6 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 CJ2  A 402 (-4.2A)
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
 0.27A 4jtrB-6f2uA:
51.6		 4jtrB-6f2uA:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 NAP  A 401 ( 4.7A)
None
NAP  A 401 (-3.4A)
None
None
 0.98A 4nkvB-6f2uA:
undetectable		 4nkvB-6f2uA:
10.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		5 / 11 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
 0.29A 4yvpA-6f2uA:
51.2		 4yvpA-6f2uA:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
 0.23A 4yvpB-6f2uA:
51.5		 4yvpB-6f2uA:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 9 LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
TRP A 227
 None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
 1.34A 4yvvA-6f2uA:
52.8		 4yvvA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		7 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
 0.18A 4yvvA-6f2uA:
52.8		 4yvvA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 9 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A  87
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
None
CJ2  A 402 ( 4.8A)
 1.46A 4yvvB-6f2uA:
52.8		 4yvvB-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
 0.82A 4yvvB-6f2uA:
52.8		 4yvvB-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		9 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 0.92A 4yvxA-6f2uA:
52.8		 4yvxA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
LEU A 122
SER A 129
ASN A 167
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
 0.49A 4yvxA-6f2uA:
52.8		 4yvxA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A  87
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
None
CJ2  A 402 ( 4.8A)
 1.49A 4yvxB-6f2uA:
53.0		 4yvxB-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		10 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
MET A 120
ASN A 167
TRP A 227
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
 0.82A 4yvxB-6f2uA:
53.0		 4yvxB-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		11 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
MET A 120
LEU A 122
SER A 129
ASN A 167
PHE A 306
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
 0.34A 4yvxB-6f2uA:
53.0		 4yvxB-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_A_GCZA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
 1.08A 4zfcA-6f2uA:
53.0		 4zfcA-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		8 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
TRP A 227
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
 1.04A 4zfcB-6f2uA:
52.8		 4zfcB-6f2uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 8 TYR A  81
LEU A 103
LEU A  99
MET A 151
 None
 1.11A 5hs6A-6f2uA:
undetectable		 5hs6A-6f2uA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		3 / 3 CYH A 145
MET A 175
ASN A 178
 None
 1.36A 5qh8A-6f2uA:
undetectable		 5qh8A-6f2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		3 / 3 HIS A 194
SER A 217
ARG A 223
 None
NAP  A 401 ( 2.7A)
None
 0.93A 5u63A-6f2uA:
undetectable		 5u63A-6f2uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens) 		4 / 6 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A 401 (-3.8A)
None
None
 1.24A 6djzB-6f2uA:
undetectable		 6djzB-6f2uA:
undetectable