SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 282
ALA A 279
PRO A  79
VAL A 176
LEU A 171
 None
 0.92A 1df7A-6f2xA:
3.2		 1df7A-6f2xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1dfoA-6f2xA:
undetectable		 1dfoA-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1dfoB-6f2xA:
undetectable		 1dfoB-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1dfoC-6f2xA:
undetectable		 1dfoC-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1dfoD-6f2xA:
undetectable		 1dfoD-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.11A 1eqbA-6f2xA:
undetectable		 1eqbA-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1eqbB-6f2xA:
undetectable		 1eqbB-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.11A 1eqbC-6f2xA:
undetectable		 1eqbC-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 221
GLY A 247
HIS A 251
LEU A 225
ALA A 249
 None
 1.12A 1eqbD-6f2xA:
undetectable		 1eqbD-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 249
VAL A 245
ALA A 248
HIS A 251
 None
 1.16A 1q23A-6f2xA:
undetectable		 1q23A-6f2xA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 164
GLY A 165
PHE A 202
ILE A 198
 None
 0.82A 2y7wC-6f2xA:
undetectable		 2y7wC-6f2xA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 261
TYR A 262
GLY A 263
ASP A 266
 None
 1.13A 3kl3A-6f2xA:
undetectable		 3kl3A-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4eilA-6f2xA:
3.2		 4eilA-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.37A 4eilB-6f2xA:
2.0		 4eilB-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4eilC-6f2xA:
4.8		 4eilC-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.44A 4eilD-6f2xA:
2.3		 4eilD-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.39A 4eilE-6f2xA:
3.8		 4eilE-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.44A 4kyaA-6f2xA:
4.9		 4kyaA-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4kyaB-6f2xA:
2.5		 4kyaB-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.44A 4kyaC-6f2xA:
undetectable		 4kyaC-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.45A 4kyaD-6f2xA:
undetectable		 4kyaD-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4kyaE-6f2xA:
3.1		 4kyaE-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4kyaF-6f2xA:
undetectable		 4kyaF-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.43A 4kyaG-6f2xA:
4.1		 4kyaG-6f2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6f2x PROTEIN TYROSINE
KINASE A
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 258
ALA A 280
PHE A 267
ARG A 241
VAL A 257
 None
 1.45A 4kyaH-6f2xA:
undetectable		 4kyaH-6f2xA:
undetectable