SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 8 PHE A 408
ILE A 258
LEU A 261
LEU A  77
 None
 0.77A 1eupA-6f34A:
0.0		 1eupA-6f34A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 LEU A 261
ASP A 237
SER A 391
PHE A 236
ILE A 234
 None
ARG  A 501 ( 4.8A)
None
None
ARG  A 501 (-3.7A)
 1.27A 1uobA-6f34A:
undetectable		 1uobA-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 LEU A 372
GLY A  50
ALA A  52
HIS A  56
ALA A  57
 None
 1.04A 2bm9F-6f34A:
undetectable		 2bm9F-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 5 TYR A  95
TYR A  79
ILE A 257
GLY A  90
 None
 1.21A 2du8G-6f34A:
undetectable		 2du8G-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 5 TYR A  95
TYR A  79
ILE A 257
GLY A  90
 None
 1.21A 2du8J-6f34A:
undetectable		 2du8J-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 11 THR A 276
THR A  49
GLY A  58
ALA A  54
SER A 272
 None
 1.02A 2f162-6f34A:
undetectable		 2f162-6f34A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 11 THR A 276
THR A  49
GLY A  58
ALA A  54
SER A 272
 None
 1.03A 2f16N-6f34A:
undetectable		 2f16N-6f34A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 8 ALA A  76
GLY A 235
ILE A 234
THR A 265
 None
None
ARG  A 501 (-3.7A)
None
 0.67A 3el9A-6f34A:
undetectable		 3el9A-6f34A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 11 GLY A 109
THR A 389
ASP A 111
ILE A 113
GLN A 325
 None
 1.27A 3id5B-6f34A:
undetectable		 3id5B-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 THR A 276
THR A  49
GLY A  58
ALA A  54
SER A 272
 None
 1.09A 3mg02-6f34A:
undetectable
3mg0V-6f34A:
undetectable		 3mg02-6f34A:
18.32
3mg0V-6f34A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 11 THR A 276
THR A  49
GLY A  58
ALA A  54
SER A 272
 None
 1.09A 3mg0N-6f34A:
undetectable		 3mg0N-6f34A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 TYR A 268
LEU A 261
SER A  64
PHE A 230
PHE A 387
 None
 1.21A 3ugrA-6f34A:
undetectable		 3ugrA-6f34A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		3 / 3 TRP A 442
VAL A 440
TRP A 110
 None
 1.32A 3zq8A-6f34A:
undetectable
3zq8B-6f34A:
undetectable		 3zq8A-6f34A:
undetectable
3zq8B-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 6 GLY A 221
ALA A  57
TYR A 217
GLU A  55
 None
 0.88A 4ae1A-6f34A:
undetectable		 4ae1A-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 ILE A 314
THR A  43
LEU A 372
ILE A 165
VAL A 166
 None
ARG  A 501 (-4.6A)
None
None
None
 0.80A 4c9lA-6f34A:
undetectable		 4c9lA-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 ILE A 314
THR A  43
LEU A 372
ILE A 165
VAL A 166
 None
ARG  A 501 (-4.6A)
None
None
None
 0.80A 4c9lB-6f34A:
undetectable		 4c9lB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 ILE A 314
THR A  43
LEU A 372
ILE A 165
VAL A 166
 None
ARG  A 501 (-4.6A)
None
None
None
 0.79A 4c9oA-6f34A:
undetectable		 4c9oA-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 ILE A 314
THR A  43
LEU A 372
ILE A 165
VAL A 166
 None
ARG  A 501 (-4.6A)
None
None
None
 0.80A 4c9oB-6f34A:
undetectable		 4c9oB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 LEU A 112
TYR A 116
ILE A 234
GLY A 382
 None
ARG  A 501 (-3.9A)
ARG  A 501 (-3.7A)
None
 0.91A 4eq4A-6f34A:
undetectable		 4eq4A-6f34A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 LEU A 112
TYR A 116
ILE A 234
GLY A 382
 None
ARG  A 501 (-3.9A)
ARG  A 501 (-3.7A)
None
 0.92A 4eqlA-6f34A:
undetectable		 4eqlA-6f34A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 LEU A 112
TYR A 116
ILE A 234
GLY A 382
 None
ARG  A 501 (-3.9A)
ARG  A 501 (-3.7A)
None
 0.94A 4eqlB-6f34A:
undetectable		 4eqlB-6f34A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 GLY A 126
GLY A 129
ALA A 149
ALA A 122
PHE A  46
 None
 1.02A 4kicB-6f34A:
undetectable		 4kicB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 6 LEU A 112
TYR A 116
ILE A 234
GLY A 382
 None
ARG  A 501 (-3.9A)
ARG  A 501 (-3.7A)
None
 0.99A 4l39A-6f34A:
undetectable		 4l39A-6f34A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		3 / 3 ARG A 327
GLU A 245
TYR A 323
 None
None
OLC  A 503 (-3.7A)
 0.94A 4r29D-6f34A:
0.9		 4r29D-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 4 GLY A  38
VAL A 317
PHE A 230
ILE A 234
 None
ARG  A 501 (-4.7A)
None
ARG  A 501 (-3.7A)
 1.13A 4xv2B-6f34A:
undetectable		 4xv2B-6f34A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 9 THR A 228
VAL A  51
GLY A  50
THR A  49
VAL A 229
 None
 1.31A 5cp4A-6f34A:
undetectable		 5cp4A-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 SER A  89
GLY A  90
TYR A 323
ALA A 238
 None
None
OLC  A 503 (-3.7A)
None
 0.93A 5e26A-6f34A:
undetectable
5e26B-6f34A:
undetectable		 5e26A-6f34A:
undetectable
5e26B-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 5 MET A 322
SER A 321
GLY A 117
ALA A 119
 None
ARG  A 501 (-3.4A)
None
ARG  A 501 (-3.3A)
 0.93A 5k50A-6f34A:
undetectable		 5k50A-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 6 GLY A 382
GLU A 115
PHE A 385
ILE A 107
 None
ARG  A 501 (-2.8A)
None
None
 0.92A 5kmfA-6f34A:
undetectable
5kmfC-6f34A:
1.6		 5kmfA-6f34A:
12.11
5kmfC-6f34A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 SER A  68
LEU A  61
ILE A  45
LEU A 431
LEU A 427
 None
 1.32A 5ycpA-6f34A:
undetectable		 5ycpA-6f34A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		3 / 3 TYR A  97
PRO A   8
LEU A  11
 None
 0.93A 6beoA-6f34A:
undetectable		 6beoA-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		5 / 12 SER A  64
PHE A 219
VAL A 222
THR A 265
LEU A 266
 None
 1.32A 6djzB-6f34A:
undetectable		 6djzB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 ASP A 159
GLY A 133
SER A 128
GLY A 129
 None
 0.88A 6ekzA-6f34A:
undetectable		 6ekzA-6f34A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 6 ASN A 184
VAL A 188
LYS A 191
THR A 316
 None
 1.46A 6f32B-6f34A:
undetectable		 6f32B-6f34A:
undetectable