SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 1zzrA-6f49A:
undetectable
1zzrB-6f49A:
undetectable		 1zzrA-6f49A:
undetectable
1zzrB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.27A 1zzuA-6f49A:
undetectable
1zzuB-6f49A:
undetectable		 1zzuA-6f49A:
undetectable
1zzuB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6f49 -
(-) 		3 / 3 ARG A 182
ARG A 210
ARG A 213
 None
 1.02A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6f49 -
(-) 		3 / 3 ARG A 210
ARG A 213
ARG A 182
 None
 1.07A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6f49 -
(-) 		3 / 3 ARG A 213
ARG A 182
ARG A 210
 None
 1.09A 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable		 2jb7A-6f49A:
undetectable
2jb7B-6f49A:
undetectable
2jb7C-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 VAL A 196
ARG A 223
VAL A 113
GLU A 195
 None
 1.24A 3dqrA-6f49A:
undetectable
3dqrB-6f49A:
undetectable		 3dqrA-6f49A:
undetectable
3dqrB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.20A 3dqrA-6f49A:
undetectable
3dqrB-6f49A:
undetectable		 3dqrA-6f49A:
undetectable
3dqrB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.26A 3jx2A-6f49A:
undetectable
3jx2B-6f49A:
undetectable		 3jx2A-6f49A:
undetectable
3jx2B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.26A 3jx3A-6f49A:
undetectable
3jx3B-6f49A:
undetectable		 3jx3A-6f49A:
undetectable
3jx3B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 3jx4A-6f49A:
undetectable
3jx4B-6f49A:
undetectable		 3jx4A-6f49A:
undetectable
3jx4B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 3jx5A-6f49A:
undetectable
3jx5B-6f49A:
undetectable		 3jx5A-6f49A:
undetectable
3jx5B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.27A 3jx6A-6f49A:
undetectable
3jx6B-6f49A:
undetectable		 3jx6A-6f49A:
undetectable
3jx6B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.21A 3nljA-6f49A:
undetectable
3nljB-6f49A:
undetectable		 3nljA-6f49A:
undetectable
3nljB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 3nlpA-6f49A:
undetectable
3nlpB-6f49A:
undetectable		 3nlpA-6f49A:
undetectable
3nlpB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.23A 3nlqA-6f49A:
undetectable
3nlqB-6f49A:
undetectable		 3nlqA-6f49A:
undetectable
3nlqB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.26A 4cx3A-6f49A:
undetectable
4cx3B-6f49A:
undetectable		 4cx3A-6f49A:
undetectable
4cx3B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 VAL A 196
ARG A 223
VAL A 113
GLU A 195
 None
 1.28A 4cx4A-6f49A:
undetectable
4cx4B-6f49A:
undetectable		 4cx4A-6f49A:
undetectable
4cx4B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.25A 4cx4A-6f49A:
undetectable
4cx4B-6f49A:
undetectable		 4cx4A-6f49A:
undetectable
4cx4B-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 6f49 -
(-) 		3 / 3 ARG A 250
ASP A 248
TRP A 249
 None
 1.14A 4xdqA-6f49A:
undetectable		 4xdqA-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 5addA-6f49A:
undetectable
5addB-6f49A:
undetectable		 5addA-6f49A:
undetectable
5addB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.23A 5adeA-6f49A:
undetectable
5adeB-6f49A:
undetectable		 5adeA-6f49A:
undetectable
5adeB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 6f49 -
(-) 		4 / 6 ALA A  94
GLN A  65
ASP A 123
PRO A 124
 None
 1.09A 5c6pA-6f49A:
undetectable		 5c6pA-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 6f49 -
(-) 		3 / 3 THR A 135
ASP A 118
GLU A 206
 None
 0.85A 5fa8A-6f49A:
undetectable		 5fa8A-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 VAL A 196
ARG A 223
VAL A 113
GLU A 195
 None
 1.26A 5g0pA-6f49A:
undetectable
5g0pB-6f49A:
undetectable		 5g0pA-6f49A:
undetectable
5g0pB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f49 -
(-) 		4 / 7 GLU A 195
VAL A 196
ARG A 223
VAL A 113
 None
 1.24A 5g0pA-6f49A:
undetectable
5g0pB-6f49A:
undetectable		 5g0pA-6f49A:
undetectable
5g0pB-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 6f49 -
(-) 		4 / 7 PRO A 229
LEU A 230
MET A  63
LEU A 226
 None
 1.21A 6aycA-6f49A:
undetectable		 6aycA-6f49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6f49 -
(-) 		5 / 12 GLY A  99
GLY A 112
VAL A 164
ASP A 197
PHE A 190
 None
 1.05A 6nj9K-6f49A:
undetectable		 6nj9K-6f49A:
undetectable