SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		5 / 10 SER B 313
LEU B  94
THR B  89
LEU B  91
HIS B 309
 None
 1.47A 1a8uB-6f4cB:
undetectable		 1a8uB-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		5 / 9 GLU B 192
ILE B 196
ASP B 146
GLY B 148
TYR B 144
 None
 1.49A 1i00A-6f4cB:
undetectable		 1i00A-6f4cB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 6 ALA B 399
TYR B 409
ILE B 364
ILE B 397
 None
 1.10A 2dcfA-6f4cB:
undetectable		 2dcfA-6f4cB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		3 / 3 TRP B 288
GLN B 328
TRP B 385
 None
 1.33A 2vqyA-6f4cB:
undetectable		 2vqyA-6f4cB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 7 ALA B 399
TYR B 409
ILE B 364
ILE B 397
 None
 1.08A 2zm7A-6f4cB:
undetectable		 2zm7A-6f4cB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 5 ASP B 249
THR B 245
GLU B 339
LYS B 331
 None
 1.26A 4a3pA-6f4cB:
undetectable		 4a3pA-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 8 SER B 136
GLU B  97
TYR B  96
GLY B  90
 None
 1.07A 4fgzA-6f4cB:
undetectable
4fgzB-6f4cB:
undetectable		 4fgzA-6f4cB:
undetectable
4fgzB-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 7 MET B 276
ARG B 247
VAL B 271
GLU B 280
 None
 1.12A 4jseA-6f4cB:
undetectable
4jseB-6f4cB:
undetectable		 4jseA-6f4cB:
11.66
4jseB-6f4cB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		3 / 3 SER B 211
TYR B 177
ASP B 267
 None
 0.67A 4rp8C-6f4cB:
undetectable		 4rp8C-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 8 GLY B 235
TRP B 288
ASP B 265
ASP B 181
 None
 1.06A 5vlmB-6f4cB:
undetectable		 5vlmB-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 6 GLN B 322
VAL B 320
PRO B  60
ALA B 351
 None
 0.92A 6cduB-6f4cB:
1.1
6cduC-6f4cB:
undetectable		 6cduB-6f4cB:
undetectable
6cduC-6f4cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6f4c ALPHA-GALACTOSIDASE
(Nicotiana
benthamiana) 		4 / 7 GLN B 322
VAL B 320
PRO B  60
ALA B 351
 None
 0.95A 6cduC-6f4cB:
undetectable
6cduD-6f4cB:
undetectable		 6cduC-6f4cB:
undetectable
6cduD-6f4cB:
undetectable