SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		6 / 12 THR A 224
HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.95A 1j36A-6f4eA:
2.4		 1j36A-6f4eA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		6 / 12 THR A 224
HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.95A 1j36B-6f4eA:
2.2		 1j36B-6f4eA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.93A 1j37A-6f4eA:
2.5		 1j37A-6f4eA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.93A 1j37B-6f4eA:
2.4		 1j37B-6f4eA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.91A 1o86A-6f4eA:
2.6		 1o86A-6f4eA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.90A 2c6nA-6f4eA:
3.0		 2c6nA-6f4eA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 1.00A 2c6nB-6f4eA:
undetectable		 2c6nB-6f4eA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.87A 2x8zA-6f4eA:
2.2		 2x8zA-6f4eA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.90A 2x91A-6f4eA:
undetectable		 2x91A-6f4eA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		3 / 3 HIS A 227
GLU A 228
HIS A 231
 None
 0.20A 3kecB-6f4eA:
undetectable		 3kecB-6f4eA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		3 / 3 HIS A 231
SER A 349
GLU A 348
 None
 0.93A 3s8pA-6f4eA:
undetectable		 3s8pA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 11 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.92A 4c2pA-6f4eA:
2.6		 4c2pA-6f4eA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 HIS A 227
GLU A 228
HIS A 231
GLU A 266
TYR A 363
 None
 0.45A 4r7lA-6f4eA:
undetectable		 4r7lA-6f4eA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 ILE A 239
GLY A 178
ASN A 293
GLU A 266
PHE A 244
 None
 1.24A 5ih0A-6f4eA:
undetectable		 5ih0A-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 191
 None
 1.36A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 373
 None
 1.27A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 12 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 373
 None
 1.27A 5ljcA-6f4eA:
undetectable		 5ljcA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		4 / 4 HIS A 231
HIS A 227
TYR A 363
GLU A 266
 None
 1.36A 5pahA-6f4eA:
undetectable		 5pahA-6f4eA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		4 / 4 PHE A 187
LEU A 111
LEU A  99
VAL A 232
 None
 1.13A 5xxiA-6f4eA:
undetectable		 5xxiA-6f4eA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		5 / 9 PRO A 174
GLY A 180
SER A 132
LEU A 297
LEU A 129
 None
 1.32A 6dm0A-6f4eA:
0.7
6dm0D-6f4eA:
0.5		 6dm0A-6f4eA:
17.05
6dm0D-6f4eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X
(Clostridium
botulinum) 		4 / 5 LEU A 297
TYR A 294
ILE A 253
GLY A 180
 None
 0.87A 6hd6A-6f4eA:
undetectable		 6hd6A-6f4eA:
17.44