SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 12 ALA A 170
LEU A 147
PRO A 148
ARG A 202
ILE A 203
 None
 0.84A 1dhjB-6f4fA:
undetectable		 1dhjB-6f4fA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 7 GLU A 116
MET A  84
PHE A  14
ALA A 163
 None
None
GDN  A 301 ( 4.9A)
None
 1.23A 1linA-6f4fA:
undetectable		 1linA-6f4fA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 7 PHE A 173
PHE A 123
LEU A 143
MET A 195
 None
 1.11A 1wrlE-6f4fA:
undetectable		 1wrlE-6f4fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 10 ILE A  88
ALA A  28
ALA A  30
ALA A  95
ILE A  78
 None
 1.18A 2aclC-6f4fA:
undetectable		 2aclC-6f4fA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 5 LEU A  40
ALA A  12
ILE A  56
SER A  15
 GDN  A 301 (-3.8A)
None
GDN  A 301 (-4.3A)
GDN  A 301 ( 3.7A)
 1.01A 2othA-6f4fA:
undetectable		 2othA-6f4fA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 8 TYR A 115
LEU A 114
LEU A 143
ALA A 139
 None
PEG  A 303 ( 4.2A)
None
None
 1.08A 2wekA-6f4fA:
undetectable		 2wekA-6f4fA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 10 ILE A  88
ALA A  28
ALA A  30
ALA A  95
ILE A  78
 None
 1.08A 3falA-6f4fA:
undetectable		 3falA-6f4fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 6 ARG A  20
PRO A  57
GLU A  80
SER A  81
 None
GDN  A 301 (-4.3A)
GDN  A 301 (-2.7A)
GDN  A 301 (-2.6A)
 0.41A 3vlnA-6f4fA:
21.8		 3vlnA-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 4 ALA A 161
VAL A 165
ASP A 162
LEU A 147
 None
 0.97A 4e7gA-6f4fA:
undetectable		 4e7gA-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 7 ILE A  88
LEU A  91
LYS A  77
GLY A  62
 None
 0.94A 4hc3A-6f4fA:
undetectable		 4hc3A-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 8 PRO A  16
PHE A 216
PHE A 168
TYR A 206
 None
 1.49A 5amkA-6f4fA:
undetectable		 5amkA-6f4fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 12 ILE A 166
TYR A 206
PHE A 111
ALA A 154
SER A  81
 None
None
None
None
GDN  A 301 (-2.6A)
 1.44A 5iwuA-6f4fA:
undetectable		 5iwuA-6f4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_A_NCTA501_1
(AMINE OXIDASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 10 LEU A   9
TYR A  32
GLU A  26
THR A 219
THR A  11
 None
 1.12A 6c71A-6f4fA:
0.0		 6c71A-6f4fA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		4 / 8 LEU A   9
TYR A  32
GLU A  26
THR A  11
 None
 0.94A 6c71B-6f4fA:
undetectable		 6c71B-6f4fA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_C_NCTC501_1
(AMINE OXIDASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 10 LEU A   9
TYR A  32
GLU A  26
THR A 219
THR A  11
 None
 1.03A 6c71C-6f4fA:
0.0		 6c71C-6f4fA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_D_NCTD501_1
(AMINE OXIDASE)		 6f4f GLUTATHIONE
TRANSFERASE
(Trametes
versicolor) 		5 / 9 LEU A   9
TYR A  32
GLU A  26
THR A 219
THR A  11
 None
 0.97A 6c71D-6f4fA:
0.0		 6c71D-6f4fA:
26.19