SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RA8_A_FOLA161_1 (DIHYDROFOLATE REDUCTASE)	6f4g	PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' (Drosophila melanogaster)	3 / 3	ASP A 53 LYS A 56 ARG A 78	None	1.13A	1ra8A-6f4gA: undetectable	1ra8A-6f4gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	6f4g	PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' (Drosophila melanogaster)	3 / 3	ARG A 22 ASP A 42 ASP A 45	None	0.90A	3jb3A-6f4gA: undetectable	3jb3A-6f4gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DV1_A_SRYA1601_1 (16S RRNA RIBOSOMAL PROTEIN S12)	6f4g	PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' (Drosophila melanogaster)	3 / 3	LYS A 3 LYS A 1 PRO A 32	None	1.13A	4dv1L-6f4gA: undetectable	4dv1L-6f4gA: 24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_2 (ADENOSINE KINASE)	6f4g	PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' (Drosophila melanogaster)	4 / 5	ASN A 52 LEU A 54 LEU A 95 ASN A 123	None	1.12A	4n09C-6f4gA: undetectable	4n09C-6f4gA: 11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_H_TR6H101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	6f4g	PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' (Drosophila melanogaster)	3 / 5	GLY A 111 GLY A 82 GLU A 81	None	0.48A	4z2eA-6f4gA: undetectable 4z2eD-6f4gA: undetectable	4z2eA-6f4gA: 10.39 4z2eD-6f4gA: 14.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RA8_A_FOLA161_1","DIHYDROFOLATE REDUCTASE","6f4g","PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'","Drosophila melanogaster",3,"ASP A  53;LYS A  56;ARG A  78","None","1.13A","1ra8A-6f4gA:undetectable","1ra8A-6f4gA:undetectable"],["3JB3_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","6f4g","PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'","Drosophila melanogaster",3,"ARG A  22;ASP A  42;ASP A  45","None","0.90A","3jb3A-6f4gA:undetectable","3jb3A-6f4gA:undetectable"],["4DV1_A_SRYA1601_1","16S RRNA;RIBOSOMAL PROTEIN S12","6f4g","PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'","Drosophila melanogaster",3,"LYS A   3;LYS A   1;PRO A  32","None","1.13A","4dv1L-6f4gA:undetectable","4dv1L-6f4gA:24.60"],["4N09_C_ADNC401_2","ADENOSINE KINASE","6f4g","PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'","Drosophila melanogaster",4,"ASN A  52;LEU A  54;LEU A  95;ASN A 123","None","1.12A","4n09C-6f4gA:undetectable","4n09C-6f4gA:11.90"],["4Z2E_H_TR6H101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","6f4g","PROBABLE U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A'","Drosophila melanogaster",3,"GLY A 111;GLY A  82;GLU A  81","None","0.48A","4z2eA-6f4gA:undetectable;4z2eD-6f4gA:undetectable","4z2eA-6f4gA:10.39;4z2eD-6f4gA:14.50"]]