SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 11 ALA A 293
THR A 304
VAL A 295
LEU A 256
VAL A 252
 None
 1.18A 1rv7A-6f5eA:
undetectable
1rv7B-6f5eA:
undetectable		 1rv7A-6f5eA:
22.34
1rv7B-6f5eA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.07A 3erdA-6f5eA:
undetectable		 3erdA-6f5eA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.05A 3hm1A-6f5eA:
undetectable		 3hm1A-6f5eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 6f5e DD_D12_10_47
(synthetic
construct) 		4 / 7 VAL A  40
VAL A  73
ASN A  69
GLY A  70
 None
 1.12A 3kmoB-6f5eA:
undetectable		 3kmoB-6f5eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 ILE A 161
VAL A  96
ILE A 128
GLU A  97
GLU A  94
 None
 1.33A 4i41A-6f5eA:
undetectable		 4i41A-6f5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 0.95A 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable		 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 VAL A  63
LEU A  51
LEU A  84
ILE A  95
ALA A 104
 None
 1.00A 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable		 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 VAL A 186
LEU A 174
LEU A 207
ILE A 218
ALA A 227
 None
 1.02A 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable		 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 VAL A 252
LEU A 240
LEU A 273
ILE A 284
ALA A 293
 None
 0.98A 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable		 4p65B-6f5eA:
undetectable
4p65D-6f5eA:
undetectable
4p65I-6f5eA:
undetectable
4p65J-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 1.00A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A  84
VAL A  63
LEU A  51
ILE A  95
ALA A 104
 None
 1.03A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A 273
VAL A 252
LEU A 240
ILE A 284
ALA A 293
 None
 1.02A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 11 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.10A 4zn7B-6f5eA:
undetectable		 4zn7B-6f5eA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6f5e DD_D12_10_47
(synthetic
construct) 		5 / 12 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.30A 5eypB-6f5eA:
undetectable		 5eypB-6f5eA:
12.44