SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
5 / 12 VAL A 121
GLY A 122
TYR A 131
TYR A 150
LEU A 177
None
1.12A 1fduA-6f5oA:
undetectable
1fduA-6f5oA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 GLY B 421
SER B 269
MET B 321
LEU B  92
MET B  95
None
1.50A 1fm6D-6f5oB:
undetectable
1fm6D-6f5oB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
3 / 3 TRP C 132
HIS C 235
MET C 233
None
1.26A 1l5qB-6f5oC:
2.3
1l5qB-6f5oC:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ARG B 622
ILE B 574
TRP C 100
None
1.07A 1nodB-6f5oB:
undetectable
1nodB-6f5oB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 LEU B 600
ALA B 546
PHE B 511
ALA B 543
VAL A 431
None
1.28A 1rbpA-6f5oB:
undetectable
1rbpA-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.33A 1rs7B-6f5oB:
undetectable
1rs7B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 7 ASP B 305
ASP B 444
ASP B 445
LYS B 480
None
0.91A 1t03A-6f5oB:
7.3
1t03A-6f5oB:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
VAL C 519
None
0.97A 1xiuB-6f5oC:
undetectable
1xiuB-6f5oC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
LEU C 505
None
0.82A 1xlsA-6f5oC:
undetectable
1xlsA-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
VAL C 519
None
0.92A 1xlsA-6f5oC:
undetectable
1xlsA-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
LEU C 505
None
0.82A 1xlsB-6f5oC:
undetectable
1xlsB-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
VAL C 519
None
0.93A 1xlsB-6f5oC:
undetectable
1xlsB-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
LEU C 505
None
0.82A 1xlsC-6f5oC:
undetectable
1xlsC-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
VAL C 519
None
0.93A 1xlsC-6f5oC:
undetectable
1xlsC-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
LEU C 505
None
0.82A 1xlsD-6f5oC:
undetectable
1xlsD-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 279
VAL C 519
None
0.92A 1xlsD-6f5oC:
undetectable
1xlsD-6f5oC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 5 LEU C 330
SER C 407
LEU C 447
LEU C 399
None
0.92A 1yajD-6f5oC:
undetectable
1yajD-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 GLY A 425
ASN B 599
LEU B 588
ASP B 586
ASP B 592
None
1.30A 2b9eA-6f5oA:
undetectable
2b9eA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus;
Influenza
B
virus)
3 / 3 LYS A 568
ASP B 230
ASN C  44
None
1.06A 2bm9A-6f5oA:
undetectable
2bm9A-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
3 / 3 LYS B 207
ASP C  15
CYH B 691
None
1.32A 2br4F-6f5oB:
undetectable
2br4F-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 ASP B 210
THR B 213
GLU B 178
GLU B 216
None
1.45A 2dttB-6f5oB:
undetectable
2dttC-6f5oB:
undetectable
2dttB-6f5oB:
17.54
2dttC-6f5oB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 7 VAL A 344
SER A 348
ARG A 317
LEU A 316
None
1.13A 2f78A-6f5oA:
undetectable
2f78A-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 7 VAL A 344
SER A 348
ARG A 317
LEU A 316
None
1.10A 2f78B-6f5oA:
undetectable
2f78B-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
3 / 3 LYS C 654
GLY A 673
PRO A 674
None
1.01A 2hreB-6f5oC:
undetectable
2hreB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 9 GLY B 161
LEU B 163
LEU B 122
ASP B 120
ASP C  28
None
1.23A 2j2pB-6f5oB:
undetectable
2j2pC-6f5oB:
undetectable
2j2pB-6f5oB:
15.60
2j2pC-6f5oB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 7 THR B 468
ILE B 474
ASN B 306
GLN B 441
None
0.73A 2jc9A-6f5oB:
3.0
2jc9A-6f5oB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ARG B 622
ILE B 574
TRP C 100
None
1.05A 2nodB-6f5oB:
undetectable
2nodB-6f5oB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 6 PHE C 137
GLN C 548
ASN C 549
LEU C 677
None
1.15A 2nyrA-6f5oC:
undetectable
2nyrA-6f5oC:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ASN B 265
LEU B 266
HIS B  99
None
0.78A 2q6fB-6f5oB:
undetectable
2q6fB-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
4 / 6 ILE B  18
ARG A 659
PRO B 509
SER B 510
None
1.27A 2qd3B-6f5oB:
undetectable
2qd3B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 LEU B  89
LEU B  92
ASP B  93
ILE A 233
None
1.07A 2rlfA-6f5oB:
undetectable
2rlfB-6f5oB:
undetectable
2rlfA-6f5oB:
13.51
2rlfB-6f5oB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 LEU B  89
LEU B  92
ASP B  93
ILE A 233
None
1.16A 2rlfB-6f5oB:
undetectable
2rlfC-6f5oB:
undetectable
2rlfB-6f5oB:
13.51
2rlfC-6f5oB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
5 / 11 SER A 464
LEU A 496
ALA A 500
THR A 518
LEU A 283
None
1.07A 2v0mD-6f5oA:
undetectable
2v0mD-6f5oA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 PRO B 341
ILE B 248
ASN B 346
LEU B 222
None
1.33A 2wekB-6f5oB:
undetectable
2wekB-6f5oB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 GLN A 582
ALA B  16
ALA B  17
THR B  20
None
1.01A 2xfhA-6f5oA:
undetectable
2xfhA-6f5oA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 5 ARG C  48
ASP A 510
ILE A 565
GLU C  42
C  R  11 ( 3.4A)
C  R  11 ( 4.6A)
None
C  R  11 ( 4.1A)
1.36A 2xrzA-6f5oC:
undetectable
2xrzB-6f5oC:
undetectable
2xrzA-6f5oC:
undetectable
2xrzB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 8 ILE C 269
SER C 524
ASP C 307
SER C 520
None
1.12A 2zw9B-6f5oC:
undetectable
2zw9B-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
5 / 12 HIS A  41
ASP A 109
SER A 155
TYR A 131
ILE A 147
None
1.40A 3b7pC-6f5oA:
undetectable
3b7pC-6f5oA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 7 SER C 656
VAL C 547
TYR C 551
ILE C 650
None
1.24A 3bu1A-6f5oC:
undetectable
3bu1A-6f5oC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 ILE B 170
ASP B 169
ASN B 144
LEU B 143
LEU B 122
None
1.21A 3cjtK-6f5oB:
undetectable
3cjtK-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 10 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.89A 3falC-6f5oC:
undetectable
3falC-6f5oC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 11 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.90A 3fc6A-6f5oC:
undetectable
3fc6A-6f5oC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 11 LEU C 503
ALA C 315
GLY C 515
ILE C 313
VAL C 308
None
1.23A 3gyqB-6f5oC:
undetectable
3gyqB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 GLY B 162
GLY B 161
VAL B 119
LEU B 114
ILE B 147
None
1.21A 3h52B-6f5oB:
undetectable
3h52B-6f5oB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 GLY B 304
VAL B 302
LEU B 440
CYH B 469
ILE B 462
None
1.23A 3h52B-6f5oB:
undetectable
3h52B-6f5oB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 4 ARG B 249
ASP B 172
GLY B 157
THR B 146
None
1.24A 3k4vB-6f5oB:
undetectable
3k4vB-6f5oB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 7 GLU B 607
TYR B 554
PHE B 550
TYR B 598
None
1.23A 3ku9B-6f5oB:
3.0
3ku9B-6f5oB:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.23A 3n62A-6f5oB:
undetectable
3n62A-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.24A 3n66B-6f5oB:
undetectable
3n66B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ARG B 622
ILE B 574
TRP C 100
None
1.15A 3nw2A-6f5oB:
undetectable
3nw2A-6f5oB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ARG B 622
ILE B 574
TRP C 100
None
1.07A 3nw2B-6f5oB:
undetectable
3nw2B-6f5oB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 ALA B 424
VAL B 422
GLN B 268
None
0.66A 3of4B-6f5oB:
0.0
3of4B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 VAL C  21
ASN C  16
TYR B 688
PHE B 182
GLU B 684
None
1.22A 3q5pA-6f5oC:
undetectable
3q5pA-6f5oC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 7 GLN C 664
GLU B 485
ARG A 671
PRO A 674
None
1.35A 3ql6A-6f5oC:
undetectable
3ql6A-6f5oC:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 GLU A 585
GLY B 539
SER A 580
PHE A 629
CYH A 603
None
1.46A 3s8pB-6f5oA:
undetectable
3s8pB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 5 THR B 146
ILE B 147
PHE B 166
LEU B 122
None
1.44A 3tf1A-6f5oB:
3.5
3tf1A-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
3 / 3 LYS B 530
ARG C 211
LEU C 149
None
1.35A 3v4tE-6f5oB:
undetectable
3v4tE-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 ILE C 200
SER B 664
VAL C  98
ILE B 608
LEU B 589
None
1.04A 3w67B-6f5oC:
undetectable
3w67B-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 ILE C 200
SER B 664
VAL C  98
ILE B 608
LEU B 589
None
1.09A 3w68B-6f5oC:
undetectable
3w68B-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 9 ASN C 648
GLY C 645
GLY C 644
SER B 291
GLY C 646
None
1.21A 3ztvA-6f5oC:
undetectable
3ztvA-6f5oC:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
5 / 12 GLU A 585
GLY B 539
SER A 580
PHE A 629
CYH A 603
None
1.45A 4bupA-6f5oA:
undetectable
4bupA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 8 PHE C 365
SER C 407
ARG C 334
TRP C 359
None
1.39A 4capA-6f5oC:
undetectable
4capB-6f5oC:
undetectable
4capA-6f5oC:
14.87
4capB-6f5oC:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 8 SER C 407
ARG C 334
TRP C 359
PHE C 365
None
1.25A 4cx7A-6f5oC:
undetectable
4cx7B-6f5oC:
undetectable
4cx7A-6f5oC:
11.88
4cx7B-6f5oC:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)
6f5o POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 8 GLN C  29
ASN B 156
ASN B 144
THR B 145
None
1.40A 4d1yA-6f5oC:
undetectable
4d1yB-6f5oC:
undetectable
4d1yA-6f5oC:
16.00
4d1yB-6f5oC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 8 PHE C 365
SER C 407
ARG C 334
TRP C 359
None
1.39A 4d32A-6f5oC:
undetectable
4d32B-6f5oC:
undetectable
4d32A-6f5oC:
14.87
4d32B-6f5oC:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 11 GLY C 349
ASN C 350
VAL C 416
MET C 412
ILE C 346
None
1.44A 4j4vA-6f5oC:
undetectable
4j4vA-6f5oC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 11 GLY C 349
ASN C 350
VAL C 416
MET C 412
ILE C 346
None
1.43A 4j4vD-6f5oC:
undetectable
4j4vE-6f5oC:
undetectable
4j4vD-6f5oC:
14.69
4j4vE-6f5oC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 6 ARG C 218
ARG C 211
ASP B 655
ASP B 657
None
1.39A 4kcnB-6f5oC:
undetectable
4kcnB-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 7 TYR B  56
THR B  39
LEU B 351
THR B 226
None
1.07A 4mbsA-6f5oB:
undetectable
4mbsA-6f5oB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
3 / 3 LEU B 674
ILE B 673
ARG B 669
None
U  R  12 ( 4.2A)
None
0.62A 4mk4B-6f5oB:
undetectable
4mk4B-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.95A 4nqaH-6f5oC:
undetectable
4nqaH-6f5oC:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 7 PHE A 654
ILE A 686
PHE A 703
ASN A 704
None
0.96A 4o7gA-6f5oA:
undetectable
4o7gB-6f5oA:
undetectable
4o7gA-6f5oA:
undetectable
4o7gB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 6 PHE A 654
ILE A 686
PHE A 703
ASN A 704
None
1.04A 4o7gB-6f5oA:
undetectable
4o7gB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 7 PHE A 223
ASP A 213
PRO A 217
ILE A 208
None
1.01A 4pcuA-6f5oA:
undetectable
4pcuA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 9 ALA B 543
THR B 542
ALA B 546
ILE B 534
GLY B 537
None
1.20A 4qvqK-6f5oB:
undetectable
4qvqL-6f5oB:
undetectable
4qvqK-6f5oB:
18.36
4qvqL-6f5oB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 9 ALA B 543
THR B 542
ALA B 546
ILE B 534
GLY B 537
None
1.20A 4qvqY-6f5oB:
undetectable
4qvqZ-6f5oB:
undetectable
4qvqY-6f5oB:
18.36
4qvqZ-6f5oB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 8 PHE C 365
SER C 407
ARG C 334
TRP C 359
None
1.37A 4v3yA-6f5oC:
undetectable
4v3yB-6f5oC:
2.8
4v3yA-6f5oC:
14.87
4v3yB-6f5oC:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 5 LEU A 162
ASP A 163
TYR A 154
LEU A 156
None
1.24A 4wozF-6f5oA:
undetectable
4wozH-6f5oA:
undetectable
4wozF-6f5oA:
undetectable
4wozH-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 ILE B 248
VAL B 254
PHE B 413
THR B 322
None
1.09A 4xe5A-6f5oB:
undetectable
4xe5A-6f5oB:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
3 / 3 LEU C 220
ARG C 142
ARG C 144
None
0.89A 4yiaB-6f5oC:
undetectable
4yiaB-6f5oC:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
3 / 3 ASP C  85
GLU B 685
SER C  55
None
0.76A 5bw4B-6f5oC:
undetectable
5bw4B-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 4 CYH A 343
LEU A 339
LEU A 356
ALA A 362
None
1.14A 5hpuA-6f5oA:
undetectable
5hpuB-6f5oA:
undetectable
5hpuA-6f5oA:
undetectable
5hpuB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
5 / 12 ILE A 269
HIS A 268
TYR A 270
SER A 658
ILE A 686
None
1.42A 5iwuA-6f5oA:
undetectable
5iwuA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
5 / 12 GLY B 487
GLY B 461
ILE B 462
PHE A 677
GLY A 673
None
0.93A 5koxA-6f5oB:
3.1
5koxA-6f5oB:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
4 / 6 ASP A 512
ASN A 560
ASN A 563
GLN A 566
C  V   9 ( 4.4A)
U  V   3 ( 4.2A)
None
A  V   4 ( 2.8A)
0.99A 5l6eA-6f5oA:
undetectable
5l6eA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
4 / 6 SER C 407
ARG C 334
TRP C 359
PHE C 365
None
1.47A 5uo8A-6f5oC:
0.0
5uo8B-6f5oC:
undetectable
5uo8A-6f5oC:
11.50
5uo8B-6f5oC:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza
B
virus)
3 / 3 TYR A 536
ALA A 281
TYR A 279
None
0.85A 5uunB-6f5oA:
undetectable
5uunB-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.91A 6a5yD-6f5oC:
undetectable
6a5yD-6f5oC:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.90A 6a5zD-6f5oC:
undetectable
6a5zD-6f5oC:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus)
5 / 12 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
None
0.92A 6a5zL-6f5oC:
undetectable
6a5zL-6f5oC:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus)
4 / 6 LYS B 235
ARG B 233
GLU B 232
ALA B 231
None
1.19A 6an0A-6f5oB:
undetectable
6an0A-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 4 VAL B 119
GLY B 161
ASP C  28
ASP B 159
None
1.41A 6cjkC-6f5oB:
undetectable
6cjkC-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
B
virus;
Influenza
B
virus)
5 / 11 LEU B 373
GLN B 367
GLY B  33
LEU B 389
GLN A 388
None
A  V   8 ( 4.0A)
A  V   8 ( 3.5A)
None
A  V   7 ( 4.8A)
1.32A 6euqA-6f5oB:
undetectable
6euqA-6f5oB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 8 ASP A 427
HIS C 235
HIS A 433
GLU A 585
None
1.14A 6mn4A-6f5oA:
undetectable
6mn4A-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 8 ASP A 427
HIS C 235
HIS A 433
GLU A 585
None
1.22A 6mn4B-6f5oA:
undetectable
6mn4B-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 8 ASP A 427
HIS C 235
HIS A 433
GLU A 585
None
1.30A 6mn4C-6f5oA:
undetectable
6mn4C-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
B
virus;
Influenza
B
virus)
4 / 8 ASP A 427
HIS C 235
HIS A 433
GLU A 585
None
1.21A 6mn4D-6f5oA:
undetectable
6mn4D-6f5oA:
undetectable