SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 7 TRP A 291
THR A  77
LEU A  70
GLY A  72
 None
 0.93A 1gtiE-6f5uA:
undetectable		 1gtiE-6f5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		5 / 12 ALA A  82
GLU A 178
PHE A 160
LEU A 122
TYR A 232
 None
 1.43A 1u70A-6f5uA:
undetectable		 1u70A-6f5uA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		5 / 12 ALA A  82
GLU A 178
PHE A 160
LEU A 122
TYR A 232
 None
 1.29A 1u72A-6f5uA:
undetectable		 1u72A-6f5uA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		5 / 12 ALA A  82
GLU A 178
LEU A 122
PRO A 123
TYR A 232
 None
None
None
GOL  A 606 ( 4.2A)
None
 1.20A 2qk8A-6f5uA:
undetectable		 2qk8A-6f5uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		5 / 12 GLY A 149
ALA A 148
GLY A 145
ILE A 113
ALA A 152
 None
 0.89A 3n3iA-6f5uA:
undetectable		 3n3iA-6f5uA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 7 LYS A 276
SER A 307
THR A 309
VAL A 311
 None
 0.78A 3ozkB-6f5uA:
undetectable		 3ozkB-6f5uA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 7 PHE A 160
PHE A 176
ALA A  82
LEU A 111
 None
 0.97A 4ejgA-6f5uA:
undetectable		 4ejgA-6f5uA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 6 THR A 283
GLN A 255
THR A  77
HIS A 139
 None
 1.35A 4pfjB-6f5uA:
undetectable		 4pfjB-6f5uA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		3 / 3 ALA A 166
TYR A 162
PRO A  94
 None
 0.70A 4zdyA-6f5uA:
undetectable		 4zdyA-6f5uA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 7 GLU A 178
PHE A 176
ALA A 152
GLY A  87
 None
 1.05A 5uxdA-6f5uA:
undetectable		 5uxdA-6f5uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		4 / 5 PRO A 146
GLY A 145
THR A 144
LYS A 114
 None
 1.23A 5x23A-6f5uA:
undetectable		 5x23A-6f5uA:
10.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		7 / 12 ARG A  64
VAL A  66
LEU A  68
GLU A 100
ALA A 101
GLY A 102
LEU A 186
 CQN  A 610 (-3.8A)
CQN  A 610 (-4.0A)
None
None
CQN  A 610 (-3.4A)
CQN  A 610 ( 4.5A)
None
 0.39A 6f6iA-6f5uA:
37.1
6f6iB-6f5uA:
undetectable		 6f6iA-6f5uA:
100.00
6f6iB-6f5uA:
10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		6 / 10 ILE A  38
ARG A  64
VAL A  66
ALA A 101
LEU A 184
LEU A 186
 None
CQN  A 610 (-3.8A)
CQN  A 610 (-4.0A)
CQN  A 610 (-3.4A)
CQN  A 610 ( 4.6A)
None
 0.43A 6f6nA-6f5uA:
36.6
6f6nB-6f5uA:
undetectable		 6f6nA-6f5uA:
100.00
6f6nB-6f5uA:
10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
(Zaire
ebolavirus) 		5 / 7 ILE A  38
LEU A  43
VAL A  66
LEU A 184
LEU A 186
 None
CQN  A 610 ( 4.7A)
CQN  A 610 (-4.0A)
CQN  A 610 ( 4.6A)
None
 0.50A 6g9bA-6f5uA:
36.6
6g9bB-6f5uA:
undetectable		 6g9bA-6f5uA:
100.00
6g9bB-6f5uA:
10.00