SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		3 / 3 ASP A  69
ASP A  44
ASN A  77
 SAH  A 301 (-2.7A)
None
None
 0.76A 2bm9D-6f5zA:
9.0		 2bm9D-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 11 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.11A 2q6hA-6f5zC:
undetectable		 2q6hA-6f5zC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 11 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.15A 2q72A-6f5zC:
undetectable		 2q72A-6f5zC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 12 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.15A 2qb4A-6f5zC:
undetectable		 2qb4A-6f5zC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 11 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.15A 2qeiA-6f5zC:
undetectable		 2qeiA-6f5zC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 11 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.16A 2qjuA-6f5zC:
undetectable		 2qjuA-6f5zC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 PHE A   7
GLY A  46
GLY A  48
SER A  71
ASP A  93
 SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-3.8A)
 0.52A 3dlcA-6f5zA:
18.2		 3dlcA-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 7 ARG A  54
ASP A  16
PHE A  89
ARG A  79
 None
 1.10A 3kivA-6f5zA:
undetectable		 3kivA-6f5zA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
GLY A  70
SER A  71
MET A  74
ASP A  93
 SAH  A 301 ( 3.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.8A)
 0.56A 3ou6A-6f5zA:
18.0		 3ou6A-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
GLY A  70
SER A  71
MET A  74
ASP A  93
 SAH  A 301 ( 3.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.8A)
 0.58A 3ou7A-6f5zA:
17.7		 3ou7A-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
TRP A 108
GLY A  70
SER A  71
MET A  74
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
 1.17A 3ou7A-6f5zA:
17.7		 3ou7A-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
TRP A 108
GLY A  70
SER A  71
MET A  74
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
 1.16A 3ou7B-6f5zA:
17.9		 3ou7B-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		3 / 3 GLY A  48
ASP A  69
ASP A  93
 SAH  A 301 ( 3.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.44A 3ou7C-6f5zA:
17.8		 3ou7C-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
GLY A  70
SER A  71
MET A  74
ASP A  93
 SAH  A 301 ( 3.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.8A)
 0.54A 3ou7D-6f5zA:
17.1		 3ou7D-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  48
TRP A 108
GLY A  70
SER A  71
MET A  74
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.0A)
 1.19A 3ou7D-6f5zA:
17.1		 3ou7D-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		4 / 7 GLY A  65
THR A  41
ILE C   8
LEU C   9
 None
None
None
GOL  C 101 ( 4.7A)
 0.88A 4ejjD-6f5zA:
undetectable		 4ejjD-6f5zA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		6 / 12 GLY A  46
GLY A  48
ASP A  69
MET A  74
ASP A  93
ALA A 112
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.63A 4iv8A-6f5zA:
20.2		 4iv8A-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		6 / 12 GLY A  46
GLY A  48
ASP A  69
MET A  74
ASP A  93
ALA A 112
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.65A 4iv8B-6f5zA:
20.2		 4iv8B-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  46
GLY A  48
SER A  71
MET A  74
ALA A 112
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
 0.70A 4qtuB-6f5zA:
20.1		 4qtuB-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  46
GLY A  48
SER A  71
MET A  74
ALA A 112
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
 0.65A 4qtuD-6f5zA:
20.0		 4qtuD-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 9 VAL A  43
LEU A 177
LEU A  97
THR A 122
LEU A 123
 None
 1.32A 4ubsA-6f5zA:
undetectable		 4ubsA-6f5zA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 7 GLU A  20
ARG A  54
ASP A  58
ALA A  55
 None
 1.20A 4zz8A-6f5zA:
undetectable		 4zz8A-6f5zA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		4 / 6 LEU C  54
SER A  71
PHE A   7
GLU A   6
 None
None
SAH  A 301 (-3.5A)
None
 1.27A 5b8iA-6f5zC:
undetectable		 5b8iA-6f5zC:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 4 ASP A  44
GLY A  48
ASP A  69
ASP A  93
 None
SAH  A 301 ( 3.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.57A 5e72A-6f5zA:
15.4		 5e72A-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 7 GLY A  46
GLY A  48
SER A  49
ASP A  93
 SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-3.8A)
 0.69A 5ergB-6f5zA:
13.1		 5ergB-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 6 HIS A 165
ALA A 171
LEU A 123
TYR A 114
 None
 1.04A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		4 / 6 HIS A 165
GLU A 144
ALA A 171
TYR A 114
 None
 0.86A 5igiA-6f5zA:
undetectable		 5igiA-6f5zA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		3 / 3 ASN A 141
TYR A 114
CYH A 138
 None
 1.00A 5lsuB-6f5zA:
undetectable		 5lsuB-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 6f5z UPF0434 FAMILY
PROTEIN
(Haloferax
volcanii) 		5 / 12 LEU C   5
MET C   6
LEU C   9
ILE C  46
LEU C  35
 None
None
GOL  C 101 ( 4.7A)
None
GOL  C 101 (-4.8A)
 1.09A 5toaB-6f5zC:
undetectable		 5toaB-6f5zC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 9 LEU A  87
LEU A  68
ILE A  62
GLY A  63
ILE A 129
 None
 0.94A 5vkqC-6f5zA:
undetectable
5vkqD-6f5zA:
undetectable		 5vkqC-6f5zA:
undetectable
5vkqD-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 ASP A  44
GLY A  46
GLY A  48
ASP A  93
PHE A  94
 None
SAH  A 301 (-3.5A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.92A 6nj9K-6f5zA:
10.0		 6nj9K-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6f5z 24-STEROL
C-METHYLTRANSFERASE
(Haloferax
volcanii) 		5 / 12 GLY A  50
GLY A  67
VAL A  42
ASP A  93
PHE A  94
 None
None
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 1.06A 6nj9K-6f5zA:
10.0		 6nj9K-6f5zA:
undetectable