SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 ALA A  63
SER A  66
PHE A 126
ILE A 118
 None
 0.95A 1yc2A-6f6eA:
undetectable		 1yc2A-6f6eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 12 MET A  79
LEU A 146
ILE A 213
ALA A 159
LEU A  83
 None
 1.25A 2japA-6f6eA:
undetectable		 2japA-6f6eA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 12 MET A  79
LEU A 146
ILE A 213
ALA A 159
LEU A  83
 None
 1.25A 2japB-6f6eA:
undetectable		 2japB-6f6eA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 12 MET A  79
LEU A 146
ILE A 213
ALA A 159
LEU A  83
 None
 1.26A 2japD-6f6eA:
undetectable		 2japD-6f6eA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 9 ALA A 142
PHE A 208
ALA A 159
THR A 212
LEU A 146
 None
 1.20A 3t3sA-6f6eA:
undetectable		 3t3sA-6f6eA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 LEU A  95
ILE A  76
TYR A 162
ASN A 163
 None
None
PLM  A 404 (-4.3A)
None
 0.95A 4a9kA-6f6eA:
undetectable		 4a9kA-6f6eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 HIS A 105
HIS A 100
ASP A 201
PRO A  35
 MN  A 403 (-3.2A)
None
None
None
 1.41A 4apjA-6f6eA:
2.1
4apjP-6f6eA:
undetectable		 4apjA-6f6eA:
undetectable
4apjP-6f6eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 12 VAL A  62
ALA A  63
PHE A 188
PHE A 178
SER A  57
 None
 1.29A 4mm6A-6f6eA:
undetectable		 4mm6A-6f6eA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 TYR A 162
ASN A 163
GLU A 102
PHE A  94
 PLM  A 404 (-4.3A)
None
FE2  A 401 (-2.5A)
None
 1.47A 4twdG-6f6eA:
0.6
4twdH-6f6eA:
1.3		 4twdG-6f6eA:
11.37
4twdH-6f6eA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 9 ILE A 210
MET A  20
LEU A  23
ALA A 159
MET A 164
 None
 1.17A 5og9A-6f6eA:
undetectable		 5og9A-6f6eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		5 / 12 ILE A 210
MET A  20
LEU A  23
ALA A 159
MET A 164
 None
 0.96A 5og9B-6f6eA:
undetectable		 5og9B-6f6eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 PHE A 188
LEU A 191
ALA A  58
GLN A 193
 None
 1.06A 6b89B-6f6eA:
undetectable		 6b89B-6f6eA:
20.93