SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 8 THR A 285
GLY A 557
GLY A 230
GLY A 234
 None
None
FAD  A 601 (-3.3A)
None
 0.77A 1d0vA-6f72A:
undetectable		 1d0vA-6f72A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 5 ASP A 249
VAL A 246
SER A 241
ASP A 457
 None
 1.30A 1n2xB-6f72A:
undetectable		 1n2xB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 11 SER A 388
PHE A 333
LEU A 367
VAL A 383
VAL A 363
 None
 1.34A 1q23I-6f72A:
undetectable		 1q23I-6f72A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 TRP A 254
TYR A 516
GLY A 281
GLY A 282
ASP A 273
 None
FAD  A 601 (-4.3A)
None
None
None
 1.14A 1qzzA-6f72A:
undetectable		 1qzzA-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		6 / 12 GLY A 235
GLY A 281
GLY A 280
ALA A 248
ASP A 547
PHE A 552
 None
 1.47A 2dpmA-6f72A:
undetectable		 2dpmA-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 ALA A 247
ILE A 227
ILE A 217
ILE A 239
VAL A 225
 None
None
None
None
FAD  A 601 (-4.2A)
 0.78A 2hs1B-6f72A:
undetectable		 2hs1B-6f72A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 8 ILE A 239
LEU A 399
TYR A 391
GLY A 220
 None
None
None
FAD  A 601 ( 4.0A)
 0.90A 2vdbA-6f72A:
undetectable		 2vdbA-6f72A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 LEU A 474
PHE A 326
PHE A 370
PRO A 356
PHE A 333
 None
 1.10A 2ygpA-6f72A:
undetectable		 2ygpA-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 GLY A 336
SER A 339
ILE A 239
LEU A 240
HIS A 394
 None
 1.31A 3cs8A-6f72A:
undetectable		 3cs8A-6f72A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 8 LEU A 278
THR A 155
VAL A 289
GLY A 283
 None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.8A)
FAD  A 601 ( 3.8A)
 0.86A 3dcjB-6f72A:
undetectable		 3dcjB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 GLY A 280
GLY A 282
ASP A 249
HIS A 460
SER A 464
 None
 1.34A 3dlcA-6f72A:
undetectable		 3dlcA-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 9 LEU A 169
VAL A 551
GLY A 261
ALA A 143
ILE A 150
 None
 0.96A 3el0B-6f72A:
undetectable		 3el0B-6f72A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 ARG A 262
LEU A 264
VAL A 289
THR A 258
VAL A 256
 None
None
FAD  A 601 (-3.8A)
None
None
 1.04A 3gguA-6f72A:
undetectable		 3gguA-6f72A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 9 TYR A 532
PHE A 531
GLY A 281
VAL A 515
GLN A 503
 None
 1.41A 3kmoA-6f72A:
undetectable		 3kmoA-6f72A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 9 TYR A 532
PHE A 531
GLY A 282
VAL A 515
GLN A 503
 None
 1.33A 3kmoA-6f72A:
undetectable		 3kmoA-6f72A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 11 ASP A 135
ALA A 134
GLY A 132
VAL A 128
VAL A 257
 None
 1.41A 4c5lA-6f72A:
undetectable		 4c5lA-6f72A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 9 ASP A 135
ALA A 134
GLY A 132
VAL A 128
VAL A 257
 None
 1.42A 4c5lB-6f72A:
undetectable		 4c5lB-6f72A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 10 ASP A 135
ALA A 134
GLY A 132
VAL A 128
VAL A 257
 None
 1.35A 4c5lC-6f72A:
undetectable		 4c5lC-6f72A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 10 ASP A 135
ALA A 134
GLY A 132
VAL A 128
VAL A 257
 None
 1.41A 4c5lD-6f72A:
undetectable		 4c5lD-6f72A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		3 / 3 PHE A 453
ASP A 335
ARG A 420
 None
 0.89A 4eahF-6f72A:
undetectable		 4eahF-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		3 / 3 PHE A 453
ASP A 335
ARG A 420
 None
 0.89A 4eahG-6f72A:
undetectable		 4eahG-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 ALA A 247
ILE A 227
ILE A 217
ILE A 239
VAL A 225
 None
None
None
None
FAD  A 601 (-4.2A)
 0.81A 4q1yB-6f72A:
undetectable		 4q1yB-6f72A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 PHE A 531
THR A 285
SER A 560
ASP A 547
GLY A 283
 None
None
None
None
FAD  A 601 ( 3.8A)
 1.48A 4qb9E-6f72A:
undetectable		 4qb9E-6f72A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 7 LEU A 374
THR A 305
ALA A 351
LEU A 349
 None
 0.75A 4ubsA-6f72A:
undetectable		 4ubsA-6f72A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 10 ALA A 287
LEU A 264
LEU A 278
ALA A 266
ALA A 277
 None
 1.07A 4zbrA-6f72A:
undetectable		 4zbrA-6f72A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 4 ALA A 493
PRO A 411
LEU A 160
HIS A 522
 None
 1.15A 5eskA-6f72A:
undetectable		 5eskA-6f72A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 6 THR A 155
GLY A 226
GLU A 202
ILE A 217
 FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
None
None
 0.86A 5kmfA-6f72A:
undetectable
5kmfC-6f72A:
2.2		 5kmfA-6f72A:
14.86
5kmfC-6f72A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		3 / 3 THR A 424
PRO A 331
ASP A 332
 None
 0.91A 5l8dB-6f72A:
undetectable		 5l8dB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		3 / 3 THR A 424
PRO A 331
ASP A 332
 None
 0.91A 5mwuB-6f72A:
undetectable		 5mwuB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 12 VAL A 218
LEU A 399
THR A 221
GLY A 220
VAL A 302
 None
None
FAD  A 601 (-3.0A)
FAD  A 601 ( 4.0A)
None
 1.22A 5tuiB-6f72A:
undetectable		 5tuiB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 5 ASP A 373
ARG A 377
LEU A 474
MET A 473
 None
 1.29A 5tuiB-6f72A:
undetectable		 5tuiB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 7 TYR A 231
TRP A 469
ASP A 451
TYR A 342
 FAD  A 601 (-4.7A)
None
None
None
 1.26A 5vlmG-6f72A:
undetectable		 5vlmG-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 5 MET A 292
TYR A 207
GLY A 219
GLY A 220
 None
None
None
FAD  A 601 ( 4.0A)
 1.18A 5x7pA-6f72A:
undetectable		 5x7pA-6f72A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		4 / 7 ARG A 270
THR A 269
PRO A 268
PRO A 188
 None
 1.35A 6a4iB-6f72A:
undetectable		 6a4iB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 6f72 MTVAO615
(Thermothelomyces
thermophila) 		5 / 10 LEU A 366
LEU A 374
PHE A 333
GLY A 308
VAL A 383
 None
 0.92A 6eu9B-6f72A:
undetectable		 6eu9B-6f72A:
18.48