SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.03A 1c8lA-6f74A:
undetectable		 1c8lA-6f74A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 290
ASN A 559
SER A 496
GLY A 557
VAL A 582
 None
 1.12A 1ffyA-6f74A:
undetectable		 1ffyA-6f74A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.03A 1gfzA-6f74A:
undetectable		 1gfzA-6f74A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLU A 543
LEU A 471
TYR A 352
GLY A 247
GLY A 229
 FAD  A 601 (-3.9A)
None
None
None
FAD  A 601 ( 4.0A)
 1.25A 1httD-6f74A:
undetectable		 1httD-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLU A 543
LEU A 471
TYR A 352
GLY A 247
GLY A 230
 FAD  A 601 (-3.9A)
None
None
None
FAD  A 601 (-3.6A)
 1.19A 1httD-6f74A:
undetectable		 1httD-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifA-6f74A:
undetectable		 1kifA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifB-6f74A:
undetectable		 1kifB-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifC-6f74A:
undetectable		 1kifC-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifD-6f74A:
undetectable		 1kifD-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifE-6f74A:
undetectable		 1kifE-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifF-6f74A:
undetectable		 1kifF-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifG-6f74A:
undetectable		 1kifG-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifH-6f74A:
undetectable		 1kifH-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.00A 1l5qA-6f74A:
undetectable		 1l5qA-6f74A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 0.99A 1l5qB-6f74A:
undetectable		 1l5qB-6f74A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.00A 1l7xA-6f74A:
undetectable		 1l7xA-6f74A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.01A 1l7xB-6f74A:
undetectable		 1l7xB-6f74A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 229
 None
None
None
FAD  A 601 ( 4.0A)
 1.31A 1ve9A-6f74A:
undetectable		 1ve9A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.31A 1ve9A-6f74A:
undetectable		 1ve9A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 10 HIS A 205
HIS A 301
THR A 274
GLU A 279
GLU A 262
 None
 1.35A 2dttA-6f74A:
undetectable
2dttC-6f74A:
undetectable		 2dttA-6f74A:
20.00
2dttC-6f74A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 10 HIS A 205
HIS A 301
THR A 274
GLU A 279
GLU A 262
 None
 1.43A 2dttD-6f74A:
undetectable
2dttF-6f74A:
undetectable		 2dttD-6f74A:
20.00
2dttF-6f74A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 11 HIS A 205
HIS A 301
THR A 274
GLU A 279
GLU A 262
 None
 1.49A 2dttD-6f74A:
undetectable
2dttE-6f74A:
undetectable		 2dttD-6f74A:
20.00
2dttE-6f74A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 2du8G-6f74A:
undetectable		 2du8G-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 SER A 299
THR A 189
GLN A 185
 None
 0.85A 2fk8A-6f74A:
undetectable		 2fk8A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 SER A 423
PRO A 232
ALA A 249
PRO A 248
VAL A 215
 None
 1.21A 2zifB-6f74A:
undetectable		 2zifB-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 TYR A 419
TYR A 352
PHE A 253
ALA A 350
TYR A 415
 None
 1.46A 3apwA-6f74A:
undetectable		 3apwA-6f74A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 ALA A 209
LEU A 298
SER A 299
SER A 156
LEU A 173
 None
None
None
FAD  A 601 (-2.6A)
None
 1.34A 3bxoA-6f74A:
undetectable		 3bxoA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.02A 3dd1A-6f74A:
undetectable		 3dd1A-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 0.97A 3dd1B-6f74A:
undetectable		 3dd1B-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.01A 3ddsA-6f74A:
undetectable		 3ddsA-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.00A 3ddsB-6f74A:
undetectable		 3ddsB-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 1.00A 3ddwA-6f74A:
undetectable		 3ddwA-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 HIS A 301
ALA A 203
GLY A 201
TYR A 188
 None
 0.99A 3ddwB-6f74A:
undetectable		 3ddwB-6f74A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 239
GLY A 295
GLY A 293
GLY A 291
ILE A 296
 FAD  A 601 (-3.5A)
None
None
None
None
 0.93A 3eluA-6f74A:
undetectable		 3eluA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 7 ILE A 265
LYS A 567
TYR A 570
GLY A 293
 None
GOL  A 606 (-4.9A)
None
None
 0.98A 3em0B-6f74A:
undetectable		 3em0B-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 TYR A 352
TYR A 540
GLY A 247
 None
FAD  A 601 (-4.9A)
None
 0.76A 3eteB-6f74A:
undetectable
3eteD-6f74A:
undetectable
3eteF-6f74A:
undetectable		 3eteB-6f74A:
11.68
3eteD-6f74A:
11.68
3eteF-6f74A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 4 LEU A 403
PRO A 320
LEU A 330
ARG A 452
 None
 1.46A 3hcoA-6f74A:
undetectable		 3hcoA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 THR A 157
GLY A 424
SER A 423
TYR A 419
ASN A  99
 FAD  A 601 (-2.9A)
None
None
None
FAD  A 601 (-4.0A)
 1.32A 3hiiA-6f74A:
undetectable		 3hiiA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 THR A 157
GLY A 424
SER A 423
TYR A 419
ASN A  99
 FAD  A 601 (-2.9A)
None
None
None
FAD  A 601 (-4.0A)
 1.32A 3hiiB-6f74A:
undetectable		 3hiiB-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 270
ASP A 269
ASP A 571
ILE A 575
LEU A 142
 None
 1.32A 3iv6B-6f74A:
undetectable		 3iv6B-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 6 GLU A 585
PRO A 572
ARG A 568
GLY A 583
 None
None
GOL  A 606 (-4.1A)
GOL  A 606 (-3.9A)
 1.45A 3oxvA-6f74A:
undetectable		 3oxvA-6f74A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 PRO A  62
ILE A  63
TYR A 168
TRP A  39
 None
 1.42A 3phaA-6f74A:
undetectable		 3phaA-6f74A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 8 TYR A 352
TRP A 240
LEU A 255
TRP A 493
 None
FAD  A 601 (-4.2A)
None
None
 1.39A 3uzzB-6f74A:
undetectable		 3uzzB-6f74A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 HIS A 246
TRP A 493
LEU A 162
ASP A 548
 FAD  A 601 (-3.3A)
None
None
None
 1.15A 4aqlA-6f74A:
undetectable		 4aqlA-6f74A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 341
LEU A 337
MET A 393
GLY A 353
LEU A 472
 None
 1.02A 4lmnA-6f74A:
undetectable		 4lmnA-6f74A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 THR A  27
PRO A  28
PHE A 587
ASN A 149
 None
None
GOL  A 606 (-4.6A)
GOL  A 605 (-3.6A)
 1.50A 4mf6A-6f74A:
undetectable		 4mf6A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 247
GLY A 229
THR A 250
GLY A 244
LEU A 489
 None
FAD  A 601 ( 4.0A)
None
None
None
 1.03A 4n48A-6f74A:
undetectable		 4n48A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 247
GLY A 229
THR A 250
GLY A 244
LEU A 489
 None
FAD  A 601 ( 4.0A)
None
None
None
 1.03A 4n48B-6f74A:
undetectable		 4n48B-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 11 GLY A 289
GLY A 488
GLY A 238
GLN A 300
PHE A 284
 None
None
FAD  A 601 (-3.3A)
None
None
 1.11A 4qoiA-6f74A:
undetectable
4qoiB-6f74A:
undetectable		 4qoiA-6f74A:
16.81
4qoiB-6f74A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 10 LEU A 298
LEU A 283
ALA A 286
ALA A 275
GLY A 295
 None
 1.41A 4rn6A-6f74A:
undetectable		 4rn6A-6f74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 294
GLY A 583
TYR A 556
GLY A 557
 None
GOL  A 606 (-3.9A)
None
None
 0.96A 5ayfA-6f74A:
undetectable		 5ayfA-6f74A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		6 / 12 GLY A 488
GLY A 256
GLY A 244
HIS A 246
VAL A 227
ASP A 258
 None
None
None
FAD  A 601 (-3.3A)
None
None
 1.47A 5ekxB-6f74A:
undetectable		 5ekxB-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 7 TYR A 540
ILE A 435
GLY A 546
THR A 580
 FAD  A 601 (-4.9A)
None
None
None
 0.94A 5esmA-6f74A:
undetectable		 5esmA-6f74A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 ALA A 129
ILE A 434
GLY A 546
THR A 580
THR A 154
 None
None
None
None
FAD  A 601 (-4.2A)
 1.13A 5jlcA-6f74A:
undetectable		 5jlcA-6f74A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 GLN A 519
THR A 523
ASP A 545
 None
 0.91A 5k9dA-6f74A:
undetectable		 5k9dA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 488
GLY A 256
GLY A 244
GLY A 289
ASP A 258
 None
 0.92A 5njvC-6f74A:
undetectable		 5njvC-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 TRP A 493
MET A 541
ASN A 542
 None
None
FAD  A 601 (-4.1A)
 1.24A 5uc1B-6f74A:
undetectable		 5uc1B-6f74A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 TRP A 493
MET A 541
ASN A 542
 None
None
FAD  A 601 (-4.1A)
 1.23A 5uc1A-6f74A:
undetectable		 5uc1A-6f74A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 100
GLU A 543
TYR A 419
HIS A 246
 FAD  A 601 (-4.0A)
FAD  A 601 (-3.9A)
None
FAD  A 601 (-3.3A)
 1.31A 6ep4A-6f74A:
undetectable		 6ep4A-6f74A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 312
ALA A 385
LYS A 387
 None
 0.73A 6fgcA-6f74A:
undetectable		 6fgcA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 6f74 ALCOHOL OXIDASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 312
ALA A 385
LYS A 387
 None
 0.71A 6fgdA-6f74A:
undetectable		 6fgdA-6f74A:
undetectable