SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A 128
ALA A 129
LEU A 262
VAL A 255
ILE A 266
 None
 1.31A 1claA-6f85A:
undetectable		 1claA-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 12 PHE A  64
LEU A 280
PHE A  38
VAL A 163
ALA A 303
 None
 1.25A 1q23H-6f85A:
undetectable
1q23I-6f85A:
undetectable		 1q23H-6f85A:
17.35
1q23I-6f85A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 LEU A 140
PRO A 133
VAL A 136
ILE A 137
 None
 1.01A 2aoiB-6f85A:
undetectable		 2aoiB-6f85A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 9 ILE A 322
ILE A 266
GLU A 267
ALA A 264
THR A 241
 None
 1.38A 2dtjA-6f85A:
undetectable
2dtjB-6f85A:
undetectable		 2dtjA-6f85A:
undetectable
2dtjB-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 112
LEU A 393
LEU A 124
PHE A 128
LEU A 354
 None
 1.03A 2oipA-6f85A:
undetectable		 2oipA-6f85A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 112
LEU A 393
LEU A 124
PHE A 128
LEU A 354
 None
 1.01A 3hj3C-6f85A:
undetectable		 3hj3C-6f85A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 12 VAL A 112
LEU A 393
LEU A 124
PHE A 128
LEU A 354
 None
 1.11A 3hj3D-6f85A:
undetectable		 3hj3D-6f85A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  19
ASN A 308
ALA A 306
ILE A  42
PHE A   9
 None
 1.41A 3t3qA-6f85A:
28.7		 3t3qA-6f85A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  19
ASN A 308
ALA A 306
ILE A  42
PHE A   9
 None
 1.46A 3t3qB-6f85A:
28.8		 3t3qB-6f85A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  19
ASN A 308
ALA A 306
ILE A  42
PHE A   9
 None
 1.44A 3t3qC-6f85A:
28.8		 3t3qC-6f85A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 PHE A  19
ASN A 308
ALA A 306
ILE A  42
PHE A   9
 None
 1.46A 3t3qD-6f85A:
28.9		 3t3qD-6f85A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		3 / 3 PHE A 374
CYH A 273
HIS A 243
 None
 1.29A 3u9fF-6f85A:
undetectable		 3u9fF-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		3 / 3 PHE A 374
CYH A 273
HIS A 243
 None
 1.33A 3u9fL-6f85A:
undetectable		 3u9fL-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 ALA A 177
ARG A 176
GLY A 179
LEU A 224
ILE A 185
 None
 1.10A 3wdmB-6f85A:
undetectable		 3wdmB-6f85A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 ALA A 177
ARG A 176
GLY A 179
LEU A 224
ILE A 185
 None
 1.18A 3wdmD-6f85A:
undetectable		 3wdmD-6f85A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 11 PHE A  38
ASN A   7
GLY A  39
ALA A 383
GLY A 377
 None
 1.31A 4a6nA-6f85A:
undetectable		 4a6nA-6f85A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 7 ALA A 346
PRO A 344
GLU A 267
LEU A 237
 HEM  A 501 ( 3.7A)
None
None
HEM  A 501 (-3.4A)
 0.86A 4iomA-6f85A:
undetectable		 4iomA-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 12 GLU A 101
SER A 109
LEU A 132
VAL A 113
LEU A 364
 None
 1.40A 4k36A-6f85A:
undetectable		 4k36A-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 11 GLU A 101
SER A 109
LEU A 132
VAL A 113
LEU A 364
 None
 1.41A 4k37A-6f85A:
undetectable		 4k37A-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 11 GLU A 101
SER A 109
LEU A 132
VAL A 113
LEU A 364
 None
 1.40A 4k37B-6f85A:
undetectable		 4k37B-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 10 ILE A 137
ALA A 145
PHE A 141
THR A 181
ILE A 227
 None
 1.25A 4km0A-6f85A:
undetectable		 4km0A-6f85A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 6 LEU A 205
LEU A 226
VAL A 223
PHE A  91
 None
HEM  A 501 (-4.5A)
None
None
 1.24A 4uswA-6f85A:
undetectable		 4uswA-6f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.15A 5hm8A-6f85A:
undetectable		 5hm8A-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8B-6f85A:
undetectable		 5hm8B-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8C-6f85A:
undetectable		 5hm8C-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8D-6f85A:
undetectable		 5hm8D-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8E-6f85A:
undetectable		 5hm8E-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8F-6f85A:
undetectable		 5hm8F-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8H-6f85A:
undetectable		 5hm8H-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		5 / 9 LEU A 184
THR A 151
ILE A 227
VAL A 223
ILE A 185
 None
 1.23A 6ef6A-6f85A:
undetectable		 6ef6A-6f85A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		6 / 6 PHE A  64
LEU A  69
ALA A  74
SER A 225
THR A 233
ASN A 276
 None
HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.34A 6f88A-6f85A:
67.2		 6f88A-6f85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		6 / 6 LEU A  69
ALA A  74
LEU A 159
SER A 225
THR A 233
ASN A 276
 HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HIS  A 502 (-4.6A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.47A 6f88B-6f85A:
69.6		 6f88B-6f85A:
100.00