SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 172
THR A 175
ILE A   4
ALA A  30
ILE A 169
 None
 0.95A 1bx4A-6f8yA:
undetectable		 1bx4A-6f8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 PHE A 297
ARG A 301
PRO A 152
SER A 143
 None
 1.32A 1gyxA-6f8yA:
1.5
1gyxB-6f8yA:
1.4		 1gyxA-6f8yA:
undetectable
1gyxB-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 169
LEU A 131
LEU A  39
GLY A  38
ALA A  41
 None
None
None
THR  A 401 (-3.4A)
None
 1.13A 1hvyD-6f8yA:
undetectable		 1hvyD-6f8yA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 296
LEU A 285
GLU A 314
GLY A 315
ARG A 330
 None
 1.29A 2bm9B-6f8yA:
undetectable		 2bm9B-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 VAL A 183
ALA A 227
PRO A  96
THR A  35
 None
None
None
THR  A 401 (-3.0A)
 1.07A 2q6oA-6f8yA:
undetectable		 2q6oA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 101
ALA A 119
ILE A 111
ILE A 184
ALA A  85
 None
 1.22A 3axtA-6f8yA:
2.2		 3axtA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 PRO A 150
LEU A 296
ALA A 332
PRO A 237
 None
 1.18A 3gv1A-6f8yA:
undetectable
3gv1C-6f8yA:
undetectable		 3gv1A-6f8yA:
undetectable
3gv1C-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 LEU A 296
ALA A 332
PRO A 237
PRO A 150
 None
 1.19A 3gv1A-6f8yA:
undetectable
3gv1B-6f8yA:
undetectable		 3gv1A-6f8yA:
undetectable
3gv1B-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 GLU A 256
TYR A 277
SER A 276
 None
 0.86A 4at0A-6f8yA:
undetectable		 4at0A-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 ALA A 141
PHE A  31
GLY A  40
ALA A  41
 THR  A 401 (-4.7A)
None
None
None
 0.69A 4zjzA-6f8yA:
2.1		 4zjzA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 ILE A 177
LEU A 321
GLY A 197
GLY A 198
 None
 0.85A 5a06B-6f8yA:
undetectable		 5a06B-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 ALA A 216
PRO A 196
LEU A 194
LEU A 193
 None
 1.13A 5dzkd-6f8yA:
undetectable
5dzkr-6f8yA:
undetectable		 5dzkd-6f8yA:
undetectable
5dzkr-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 11 ILE A 169
LEU A 131
LEU A  39
GLY A  38
ALA A  41
 None
None
None
THR  A 401 (-3.4A)
None
 1.11A 5fctA-6f8yA:
undetectable		 5fctA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 ALA A  30
ILE A 170
ILE A 139
ALA A 128
LEU A 131
 None
 1.05A 5mvmA-6f8yA:
undetectable
5mvmE-6f8yA:
undetectable		 5mvmA-6f8yA:
18.60
5mvmE-6f8yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 ILE A 170
ALA A  19
ILE A  16
ILE A 132
ALA A 128
 None
 1.13A 5mvmA-6f8yA:
undetectable
5mvmE-6f8yA:
undetectable		 5mvmA-6f8yA:
18.60
5mvmE-6f8yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 THR A  33
ARG A 121
ILE A 132
GLU A 133
 THR  A 401 ( 3.8A)
THR  A 401 (-3.1A)
None
None
 1.34A 5uigA-6f8yA:
undetectable		 5uigA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ILE A  16
VAL A 107
VAL A  49
VAL A  29
ALA A  19
 None
 1.47A 6a7pB-6f8yA:
undetectable		 6a7pB-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  26
ILE A 170
GLY A  40
ARG A  24
ALA A  20
 None
 1.00A 6c2mD-6f8yA:
undetectable		 6c2mD-6f8yA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 ARG A 195
PRO A  96
ARG A 121
ILE A  65
 THR  A 401 (-3.5A)
None
THR  A 401 (-3.1A)
THR  A 401 (-4.4A)
 1.19A 6ef6A-6f8yA:
undetectable		 6ef6A-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		4 / 5 LEU A  97
THR A 182
THR A  35
GLY A 198
 None
None
THR  A 401 (-3.0A)
None
 1.23A 6gtqA-6f8yA:
undetectable		 6gtqA-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 11 ILE A 169
LEU A 131
LEU A  39
GLY A  38
ALA A  41
 None
None
None
THR  A 401 (-3.4A)
None
 1.12A 6r2eF-6f8yA:
undetectable		 6r2eF-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6f8y THREONYLCARBAMOYL-AM
P SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 169
LEU A 131
LEU A  39
GLY A  38
ALA A  41
 None
None
None
THR  A 401 (-3.4A)
None
 1.12A 6r2eH-6f8yA:
undetectable		 6r2eH-6f8yA:
undetectable