SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 640
HIS A 598
PRO A 596
 None
 0.87A 1d8cA-6f8zA:
undetectable		 1d8cA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 LYS A 200
ALA A 199
ASP A 396
GLY A 394
 None
 1.19A 1e7bA-6f8zA:
undetectable		 1e7bA-6f8zA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 366
TYR A 362
PHE A  52
 None
 0.83A 1eqbB-6f8zA:
undetectable		 1eqbB-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 366
TYR A 362
PHE A  52
 None
 0.84A 1eqbA-6f8zA:
undetectable		 1eqbA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 366
TYR A 362
PHE A  52
 None
 0.83A 1eqbD-6f8zA:
undetectable		 1eqbD-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 366
TYR A 362
PHE A  52
 None
 0.83A 1eqbC-6f8zA:
undetectable		 1eqbC-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 PRO A 546
ASP A 469
ASN A 403
TYR A 544
 None
 1.02A 1hpkA-6f8zA:
undetectable		 1hpkA-6f8zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A 241
ILE A 159
ASP A 156
GLY A 244
PHE A 243
 None
 1.30A 1i00B-6f8zA:
undetectable		 1i00B-6f8zA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 526
GLN A 540
ASN A 537
TYR A 525
GLY A 527
 None
 1.30A 1kvlA-6f8zA:
undetectable		 1kvlA-6f8zA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 595
TRP A 352
LYS A 295
 CA  A 801 (-2.9A)
None
None
 1.32A 1qu2A-6f8zA:
3.3		 1qu2A-6f8zA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 4 THR A  91
GLY A  72
ASP A  60
ALA A 167
 None
None
None
EDO  A 802 ( 4.2A)
 1.10A 1sg9A-6f8zA:
undetectable		 1sg9A-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 131
GLU A 117
TYR A 125
 None
 0.81A 1wsvA-6f8zA:
undetectable		 1wsvA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  98
LEU A  96
TYR A  45
THR A  49
ILE A  55
 None
 1.36A 1xoqA-6f8zA:
undetectable		 1xoqA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  98
LEU A  96
TYR A  45
THR A  49
ILE A  55
 None
 1.37A 1xoqB-6f8zA:
undetectable		 1xoqB-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 120
VAL A 127
LEU A 138
PRO A  46
PHE A  30
 None
 1.03A 2f8lA-6f8zA:
undetectable		 2f8lA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  28
TYR A  73
SER A 629
 None
 0.89A 2gvcB-6f8zA:
undetectable		 2gvcB-6f8zA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A  28
TYR A  73
SER A 629
 None
 0.90A 2gvcE-6f8zA:
undetectable		 2gvcE-6f8zA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 GLN A 456
TRP A 445
HIS A 404
ASP A 469
ASN A 403
 None
 1.34A 2owcA-6f8zA:
undetectable		 2owcA-6f8zA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 GLN A 456
TRP A 445
HIS A 404
ASP A 469
ASN A 403
 None
 1.33A 2owwA-6f8zA:
undetectable		 2owwA-6f8zA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 331
TYR A 329
TYR A 383
ASP A 333
 None
 1.36A 2pncA-6f8zA:
undetectable		 2pncA-6f8zA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 398
TYR A 386
GLN A 380
HIS A 437
 None
 1.45A 2qmqA-6f8zA:
undetectable		 2qmqA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 674
LEU A 676
ILE A 684
ARG A 683
 None
 1.02A 2rlfA-6f8zA:
undetectable
2rlfB-6f8zA:
undetectable		 2rlfA-6f8zA:
17.95
2rlfB-6f8zA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 696
ILE A 664
ILE A 684
PHE A 724
THR A 613
 None
 0.84A 2w9sA-6f8zA:
undetectable		 2w9sA-6f8zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 696
ILE A 664
ILE A 684
PHE A 724
THR A 613
 None
 0.84A 2w9sB-6f8zA:
undetectable		 2w9sB-6f8zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 696
ILE A 664
ILE A 684
PHE A 724
THR A 613
 None
 0.85A 2w9sC-6f8zA:
undetectable		 2w9sC-6f8zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 696
ILE A 664
PHE A 724
THR A 613
 None
 0.77A 2w9sE-6f8zA:
undetectable		 2w9sE-6f8zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 HIS A 598
GLY A 593
HIS A 592
GLY A  42
ASP A 636
 None
CA  A 801 (-4.8A)
None
None
None
 1.08A 2x1lA-6f8zA:
undetectable		 2x1lA-6f8zA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
 None
 1.25A 3b0wA-6f8zA:
undetectable		 3b0wA-6f8zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
 None
 1.26A 3b0wB-6f8zA:
undetectable		 3b0wB-6f8zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A  98
LEU A  96
TYR A  45
THR A  49
ILE A  55
 None
 1.36A 3g4lC-6f8zA:
undetectable		 3g4lC-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 593
GLY A  92
GLY A 634
LEU A  88
ASP A  95
 CA  A 801 (-4.8A)
None
None
None
None
 1.02A 3gczA-6f8zA:
undetectable		 3gczA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 MET A 650
LEU A 669
LEU A 674
PHE A 647
 None
 1.26A 3nk2X-6f8zA:
undetectable		 3nk2X-6f8zA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 734
LYS A 735
GLY A 732
PRO A 610
 None
 1.00A 3onnA-6f8zA:
undetectable		 3onnA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A 545
ASN A 656
TYR A 496
GLU A 494
 None
 1.13A 3q5sA-6f8zA:
undetectable		 3q5sA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 632
MET A 650
LEU A 361
 None
 0.92A 3vw1D-6f8zA:
undetectable		 3vw1D-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 313
ASP A 288
GLN A 292
GLU A 272
 None
 1.49A 4azvA-6f8zA:
undetectable		 4azvA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 PRO A  59
GLN A 126
TYR A 125
PHE A  83
 None
 1.36A 4grqA-6f8zA:
undetectable
4grqC-6f8zA:
undetectable		 4grqA-6f8zA:
20.83
4grqC-6f8zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 LYS A 375
ASN A 342
VAL A 339
ARG A 379
 None
 1.01A 4mv7A-6f8zA:
undetectable		 4mv7A-6f8zA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A  96
ASP A  95
GLY A 197
ASP A 168
ILE A 176
 None
 1.14A 4njtD-6f8zA:
undetectable		 4njtD-6f8zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 616
LYS A 612
LEU A 566
GLU A 563
 None
 1.48A 4olbA-6f8zA:
undetectable		 4olbA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 470
ARG A 492
GLY A 449
VAL A 444
 None
 1.07A 4oltA-6f8zA:
undetectable		 4oltA-6f8zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 470
ARG A 492
GLY A 449
VAL A 444
 None
 1.05A 4oltB-6f8zA:
undetectable		 4oltB-6f8zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 525
GLY A 536
GLN A 589
ASP A 521
HIS A 531
 None
 1.50A 4qc6A-6f8zA:
undetectable		 4qc6A-6f8zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A 374
LEU A 476
ILE A 413
ALA A 412
 None
 0.62A 4zf8A-6f8zA:
undetectable		 4zf8A-6f8zA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 535
TRP A 390
ASN A 635
 None
 0.96A 5dv4A-6f8zA:
undetectable		 5dv4A-6f8zA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 310
ALA A 311
TYR A 625
HIS A 314
 None
 1.40A 5ecmA-6f8zA:
undetectable		 5ecmA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 652
ILE A 711
PHE A 647
VAL A 600
THR A 363
 None
 1.26A 5esgA-6f8zA:
undetectable		 5esgA-6f8zA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 HIS A 437
SER A 432
GLN A 466
ILE A 406
 None
 1.39A 5fuqA-6f8zA:
undetectable
5fuqB-6f8zA:
undetectable		 5fuqA-6f8zA:
undetectable
5fuqB-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A  44
TRP A 644
GLU A 595
THR A 628
 None
None
CA  A 801 (-2.9A)
None
 1.43A 5hqaA-6f8zA:
7.5		 5hqaA-6f8zA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A  83
SER A  58
GLN A 126
ASP A 116
 None
 1.41A 5kpcA-6f8zA:
undetectable		 5kpcA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 588
TYR A 616
HIS A 592
THR A 623
LEU A 624
 None
 1.43A 5lsuA-6f8zA:
undetectable		 5lsuA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 380
ASP A 372
SER A 405
LEU A 387
ILE A 409
 None
 1.13A 5uacC-6f8zA:
0.8		 5uacC-6f8zA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  92
GLN A 395
TRP A 390
ASP A  95
 None
 1.27A 5vlmG-6f8zA:
undetectable		 5vlmG-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 121
VAL A  27
GLY A 123
TYR A 124
 None
 1.00A 5x80C-6f8zA:
undetectable
5x80D-6f8zA:
undetectable		 5x80C-6f8zA:
21.58
5x80D-6f8zA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 HIS A 598
ALA A 643
TYR A 632
TYR A 625
 None
 1.29A 5yodF-6f8zA:
undetectable		 5yodF-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A  54
ASP A 324
ARG A 379
 None
 1.21A 5z6jA-6f8zA:
undetectable		 5z6jA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A  54
ASP A 324
ARG A 379
 None
 1.00A 5z6kA-6f8zA:
undetectable		 5z6kA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 616
LYS A 612
LEU A 566
GLU A 563
 None
 1.43A 6cbdA-6f8zA:
undetectable		 6cbdA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 318
THR A 315
HIS A 592
GLY A  90
 None
 1.05A 6gbnC-6f8zA:
undetectable		 6gbnC-6f8zA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 125
ASN A 135
TYR A 149
PHE A  83
 None
 1.31A 6h3dA-6f8zA:
undetectable		 6h3dA-6f8zA:
undetectable