SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 636
HIS A 594
PRO A 592
 None
 0.86A 1d8cA-6f91A:
undetectable		 1d8cA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.21A 1ddrB-6f91A:
undetectable		 1ddrB-6f91A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.15A 1ddsA-6f91A:
undetectable		 1ddsA-6f91A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.19A 1ddsB-6f91A:
undetectable		 1ddsB-6f91A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.10A 1dyiB-6f91A:
undetectable		 1dyiB-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A  67
THR A  69
ASP A 344
TRP A 383
 None
EDO  A 804 (-4.1A)
None
EDO  A 804 ( 4.3A)
 1.29A 1mxdA-6f91A:
undetectable		 1mxdA-6f91A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  24
ALA A  48
SER A  49
GLY A 635
HIS A 310
 None
 1.31A 1nbiD-6f91A:
undetectable		 1nbiD-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 716
ILE A 678
PHE A 648
VAL A 697
LEU A 695
 None
 1.03A 1qhyA-6f91A:
undetectable		 1qhyA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 487
ARG A 502
PRO A 444
ASP A 446
THR A 455
 None
 1.41A 1s14A-6f91A:
undetectable		 1s14A-6f91A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A 648
TYR A 658
GLY A 715
VAL A 670
ILE A 646
 None
 1.24A 2a1oB-6f91A:
undetectable		 2a1oB-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 394
TYR A 396
TYR A 431
ASP A 462
 None
 1.09A 2qebA-6f91A:
undetectable		 2qebA-6f91A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 394
TYR A 396
TYR A 431
ASP A 462
 None
 1.10A 2qebB-6f91A:
undetectable		 2qebB-6f91A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 473
GLU A 475
ASP A 477
TYR A 419
 None
 1.11A 2yvlC-6f91A:
undetectable		 2yvlC-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.20A 2zzaA-6f91A:
undetectable		 2zzaA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.20A 2zzaB-6f91A:
undetectable		 2zzaB-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 4 ARG A 204
PHE A 236
LEU A 203
PHE A 205
 EDO  A 805 (-3.6A)
None
EDO  A 805 (-4.5A)
None
 1.44A 3ag1P-6f91A:
0.1
3ag1W-6f91A:
0.0		 3ag1P-6f91A:
undetectable
3ag1W-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 294
VAL A  15
THR A 302
 None
 0.68A 3cyxA-6f91A:
undetectable		 3cyxA-6f91A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 396
ALA A 466
ALA A 421
MET A 368
 None
 1.03A 3d91A-6f91A:
undetectable		 3d91A-6f91A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 4 ASP A 432
GLY A 395
LYS A 454
GLU A 457
 None
 1.30A 3hznD-6f91A:
undetectable		 3hznD-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 LYS A 108
SER A 105
ARG A 103
ALA A 121
ASP A 122
 None
 1.08A 3keeC-6f91A:
undetectable		 3keeC-6f91A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 487
ARG A 502
PRO A 444
ASP A 446
THR A 455
 None
 1.46A 3lpsA-6f91A:
undetectable		 3lpsA-6f91A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.18A 3ql0A-6f91A:
undetectable		 3ql0A-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 138
TYR A 116
LEU A 268
ARG A 274
 None
 1.46A 3sudD-6f91A:
undetectable		 3sudD-6f91A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 561
LEU A 603
GLU A 605
TYR A 600
 None
 1.07A 4f3tA-6f91A:
undetectable		 4f3tA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 PRO A  81
ILE A 234
TYR A 142
PHE A 236
 None
 1.10A 4g10A-6f91A:
2.0		 4g10A-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  76
ARG A  43
THR A  64
 None
 0.87A 4i13A-6f91A:
undetectable		 4i13A-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 560
VAL A 541
PHE A 557
GLU A 551
 None
 1.28A 4jseA-6f91A:
undetectable
4jseB-6f91A:
undetectable		 4jseA-6f91A:
10.51
4jseB-6f91A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 557
GLU A 551
ARG A 560
VAL A 541
 None
 1.24A 4jseA-6f91A:
undetectable
4jseB-6f91A:
undetectable		 4jseA-6f91A:
10.51
4jseB-6f91A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 556
ASP A 493
GLU A 551
VAL A 541
 None
 0.98A 4nkvA-6f91A:
undetectable		 4nkvA-6f91A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 498
LEU A 456
VAL A 651
ALA A 652
 None
 1.15A 4nkvC-6f91A:
undetectable		 4nkvC-6f91A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 556
ASP A 493
GLU A 551
VAL A 541
 None
 1.01A 4nkxB-6f91A:
undetectable		 4nkxB-6f91A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 644
ILE A 668
ILE A 646
VAL A 670
 None
 0.92A 4olmA-6f91A:
undetectable		 4olmA-6f91A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 4 TYR A 537
ILE A 394
THR A 530
TYR A 346
 None
 1.29A 4oltA-6f91A:
undetectable		 4oltA-6f91A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 537
ILE A 394
THR A 530
TYR A 346
 None
 1.26A 4oltB-6f91A:
undetectable		 4oltB-6f91A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  76
ARG A  43
THR A  64
 None
 0.90A 4p3rA-6f91A:
undetectable		 4p3rA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A 499
MET A 440
TYR A 488
 None
EDO  A 806 (-3.5A)
None
 1.15A 4p6xI-6f91A:
undetectable		 4p6xI-6f91A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 303
GLU A 591
ASP A 633
TYR A  20
GLY A 630
 None
CA  A 802 (-2.7A)
CA  A 802 (-2.8A)
None
None
 1.37A 4qb9E-6f91A:
undetectable		 4qb9E-6f91A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 SER A 303
GLU A 591
ASP A 633
TYR A  20
GLY A 630
 None
CA  A 802 (-2.7A)
CA  A 802 (-2.8A)
None
None
 1.43A 4qb9F-6f91A:
undetectable		 4qb9F-6f91A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.18A 4qlgA-6f91A:
undetectable		 4qlgA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 537
ILE A 394
THR A 530
TYR A 346
 None
 1.28A 4qwpA-6f91A:
undetectable		 4qwpA-6f91A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 170
LEU A 167
ILE A 234
LEU A 203
THR A 255
 None
None
None
EDO  A 805 (-4.5A)
None
 1.17A 4rgcA-6f91A:
undetectable		 4rgcA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 597
ILE A 583
LEU A 564
PHE A 565
 None
 0.87A 4uymA-6f91A:
undetectable		 4uymA-6f91A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.95A 4w5rA-6f91A:
undetectable		 4w5rA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.92A 4w5tA-6f91A:
undetectable		 4w5tA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.96A 4z4cA-6f91A:
undetectable		 4z4cA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.95A 4z4gA-6f91A:
undetectable		 4z4gA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.93A 4z4hA-6f91A:
undetectable		 4z4hA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 461
ALA A 398
THR A 425
TYR A 396
 None
 0.93A 4z4iA-6f91A:
undetectable		 4z4iA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A  62
HIS A  65
MET A 129
LEU A  58
 None
 1.37A 5dzke-6f91A:
undetectable
5dzks-6f91A:
undetectable		 5dzke-6f91A:
undetectable
5dzks-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A  62
HIS A  65
PRO A  38
LEU A  58
 None
 1.20A 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable		 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 449
ASP A 503
PRO A 444
GLY A 501
THR A 510
 None
 1.39A 5hfjG-6f91A:
undetectable		 5hfjG-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A 257
ASP A 316
ASN A 336
 None
 0.55A 5jglA-6f91A:
undetectable		 5jglA-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 150
LEU A 203
GLY A 202
PHE A 236
VAL A 206
 None
EDO  A 805 (-4.5A)
None
None
None
 1.14A 5x66F-6f91A:
undetectable		 5x66F-6f91A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 656
ASP A 710
ASP A 714
GLY A 715
 None
 0.97A 5x7pA-6f91A:
6.1		 5x7pA-6f91A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 678
ARG A 713
THR A 708
LEU A 707
 None
 0.95A 5xdqA-6f91A:
undetectable
5xdqJ-6f91A:
undetectable		 5xdqA-6f91A:
undetectable
5xdqJ-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 156
PHE A  79
PHE A 138
MET A 129
 None
 1.00A 5y2tB-6f91A:
undetectable		 5y2tB-6f91A:
undetectable