SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 6f9s CYTOKINESIS,
APOPTOSIS,
RNA-ASSOCIATED
PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ARG A 331
SER A 330
ASN A 326
ASP B 189
 None
 1.29A 1hwiC-6f9sA:
undetectable		 1hwiC-6f9sA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 6f9s CYTOKINESIS,
APOPTOSIS,
RNA-ASSOCIATED
PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Caenorhabditis
elegans;
Homo
sapiens) 		4 / 7 ARG A 331
SER A 330
ASN A 326
ASP B 189
 None
 1.30A 1hwiD-6f9sA:
undetectable		 1hwiD-6f9sA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens) 		5 / 12 LEU A 350
ALA A 351
SER A 355
LEU A 357
CYH A 385
 None
 1.36A 2aa5A-6f9sA:
undetectable		 2aa5A-6f9sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens) 		5 / 12 LEU A 350
ALA A 351
SER A 355
LEU A 357
CYH A 385
 None
 1.33A 2aa5B-6f9sA:
undetectable		 2aa5B-6f9sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens) 		5 / 12 LEU A 388
VAL A 406
ILE A 422
GLY A 423
ILE A 338
 None
 0.85A 2avsA-6f9sA:
undetectable		 2avsA-6f9sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens) 		5 / 12 LEU A 388
VAL A 406
ILE A 422
GLY A 423
ILE A 338
 None
 0.75A 2avvD-6f9sA:
undetectable		 2avvD-6f9sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6f9s PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens) 		3 / 3 ARG A 396
ILE A 398
PHE A 394
 None
 0.72A 5kirA-6f9sA:
undetectable		 5kirA-6f9sA:
8.04