SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 THR A 349
THR A 395
PRO A 351
 None
 0.88A 1a7yB-6fa5A:
undetectable		 1a7yB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 ILE A 448
ALA A 420
LEU A 399
LEU A 430
ILE A 417
 None
 1.23A 1g5yB-6fa5A:
undetectable		 1g5yB-6fa5A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 THR A 395
PRO A 351
THR A 349
 None
 0.86A 1i3wE-6fa5A:
undetectable		 1i3wE-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 6 GLU A 382
ILE A 545
TYR A 546
GLY A 515
 None
 1.15A 1maaB-6fa5A:
undetectable
1maaD-6fa5A:
undetectable		 1maaB-6fa5A:
11.65
1maaD-6fa5A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 THR A 349
THR A 395
PRO A 351
 None
 0.85A 1qfiB-6fa5A:
undetectable		 1qfiB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 PHE A 771
ARG A 816
ASN A 787
 None
 0.67A 1xzxX-6fa5A:
undetectable		 1xzxX-6fa5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.20A 2g70A-6fa5A:
undetectable		 2g70A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.18A 2g70B-6fa5A:
undetectable		 2g70B-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.18A 2g72A-6fa5A:
2.1		 2g72A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.16A 2g72B-6fa5A:
3.8		 2g72B-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 ASP A 396
ASP A 428
ASP A 418
 None
None
MG  A1002 ( 4.2A)
 0.74A 2igtA-6fa5A:
3.8		 2igtA-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 5 ILE A 581
ARG A 625
ARG A 628
ASP A 582
 None
None
ADP  A1001 (-2.6A)
None
 1.44A 2rhmB-6fa5A:
undetectable		 2rhmB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 5 ILE A 581
ARG A 625
ARG A 628
ASP A 582
 None
None
ADP  A1001 (-2.6A)
None
 1.41A 2rhmD-6fa5A:
undetectable		 2rhmD-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 ILE A 729
ALA A 799
ALA A 805
THR A 752
MET A 746
 None
 1.35A 2x2nD-6fa5A:
undetectable		 2x2nD-6fa5A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 5 LEU A 844
ILE A 893
ILE A 843
GLY A 776
 None
 0.88A 3bufA-6fa5A:
undetectable		 3bufA-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 ILE A 417
ALA A 347
LEU A 444
GLN A 314
SER A 406
 None
 1.26A 3ia4B-6fa5A:
undetectable		 3ia4B-6fa5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 6 GLU A 576
THR A 452
ALA A 618
ALA A 617
 None
 1.23A 3ns1C-6fa5A:
undetectable		 3ns1C-6fa5A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 HIS A 335
SER A 413
ASN A 343
 None
 0.91A 3s8pB-6fa5A:
1.0		 3s8pB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 LEU A 543
THR A 580
ILE A 541
ALA A 565
VAL A 629
 None
ADP  A1001 ( 3.9A)
None
None
None
 1.25A 3vw1D-6fa5A:
undetectable		 3vw1D-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 4 GLU A 402
ASP A 383
ARG A 825
THR A 385
 None
 1.44A 4ej1A-6fa5A:
undetectable		 4ej1A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 10 PHE A 381
ARG A 816
ALA A 820
LEU A 819
ALA A 701
 None
 1.34A 4fe1A-6fa5A:
undetectable
4fe1J-6fa5A:
undetectable		 4fe1A-6fa5A:
7.42
4fe1J-6fa5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 9 LEU A 510
VAL A 497
ILE A 500
ILE A 588
GLY A 632
 None
 0.83A 4kukA-6fa5A:
undetectable		 4kukA-6fa5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 ARG A 906
HIS A 877
SER A 907
 None
 1.03A 4mjwA-6fa5A:
undetectable
4mjwB-6fa5A:
undetectable		 4mjwA-6fa5A:
undetectable
4mjwB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 7 LEU A 446
ALA A 420
LEU A 431
LEU A 430
 None
 0.82A 4ubsA-6fa5A:
undetectable		 4ubsA-6fa5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 4 GLY A 507
VAL A 629
PHE A 558
ILE A 581
 None
None
ADP  A1001 (-3.3A)
None
 1.02A 4xv2B-6fa5A:
undetectable		 4xv2B-6fa5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 ASN A 620
ALA A 619
ARG A 636
 None
 0.73A 5cvtB-6fa5A:
undetectable		 5cvtB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 0.97A 5ewzB-6fa5A:
undetectable		 5ewzB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 4 LEU A 334
ARG A 303
ILE A 330
PHE A 306
 None
 1.04A 5kirB-6fa5A:
undetectable		 5kirB-6fa5A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 1.00A 5m35B-6fa5A:
undetectable		 5m35B-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 1.04A 5m36A-6fa5A:
undetectable		 5m36A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 12 VAL A 404
LEU A 675
GLN A 666
VAL A 664
LEU A 689
 None
 1.21A 5ubbA-6fa5A:
undetectable		 5ubbA-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 6 ILE A 379
ILE A 415
LEU A 430
HIS A 426
 None
 0.76A 5vkqA-6fa5A:
2.3
5vkqB-6fa5A:
2.2		 5vkqA-6fa5A:
undetectable
5vkqB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 6 ILE A 379
ILE A 415
LEU A 430
HIS A 426
 None
 0.73A 5vkqA-6fa5A:
2.3
5vkqD-6fa5A:
2.3		 5vkqA-6fa5A:
undetectable
5vkqD-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 10 GLY A 884
ASP A 778
VAL A 898
GLU A 903
TYR A 904
 None
 1.27A 6cgdA-6fa5A:
undetectable		 6cgdA-6fa5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		4 / 5 LEU A 724
LEU A 847
THR A 742
ARG A 768
 None
 1.03A 6ew0F-6fa5A:
undetectable		 6ew0F-6fa5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 1.02A 6fn9A-6fa5A:
undetectable		 6fn9A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 1.03A 6fnaB-6fa5A:
undetectable		 6fnaB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		3 / 3 MET A 715
GLN A 714
ARG A 713
 None
 1.02A 6fnbA-6fa5A:
undetectable		 6fnbA-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 6fa5 PUTATIVE MRNA
SPLICING FACTOR
(Chaetomium
thermophilum) 		5 / 11 LEU A 444
THR A 438
ILE A 448
THR A 349
ALA A 347
 None
 1.08A 6h1lB-6fa5A:
undetectable		 6h1lB-6fa5A:
undetectable