SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		3 / 3 ASP B  96
ASP B  26
ASN B 101
 None
 0.70A 2bm9D-6faeB:
undetectable		 2bm9D-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fae ADP-RIBOSYLATION
FACTOR 1
IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A 540
VAL B  23
LEU B  88
ARG B 109
 None
 1.10A 2oiqA-6faeA:
undetectable		 2oiqA-6faeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LYS A 501
ARG A 494
VAL A 495
 None
 1.11A 2r2vC-6faeA:
undetectable
2r2vD-6faeA:
undetectable		 2r2vC-6faeA:
undetectable
2r2vD-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6fae ADP-RIBOSYLATION
FACTOR 1
IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 6 TYR B  81
ILE A 532
ASN A 563
LEU A 564
 None
EDO  B 201 ( 3.6A)
None
None
 1.28A 2wekB-6faeB:
undetectable		 2wekB-6faeB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASP A 651
LEU A 648
LEU A 676
SER A 673
 None
 0.99A 3lm8A-6faeA:
undetectable
3lm8C-6faeA:
undetectable		 3lm8A-6faeA:
14.61
3lm8C-6faeA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 457
LEU A 456
LEU A 505
ILE A 493
 None
 0.92A 3nbqC-6faeA:
undetectable		 3nbqC-6faeA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 5 LEU B 145
GLY B 144
PHE B  90
ASN B 101
 None
 1.31A 3uq6B-6faeB:
undetectable		 3uq6B-6faeB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
 None
 0.85A 4ax8A-6faeB:
2.1		 4ax8A-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
 None
 0.85A 4aztA-6faeB:
undetectable		 4aztA-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLU A 507
GLY A 457
ARG A 504
LYS A 501
 None
 1.03A 4fgzA-6faeA:
undetectable		 4fgzA-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B  50
ASP B  67
ILE A 538
VAL A 502
LEU A 505
 None
 0.89A 4fr0A-6faeB:
undetectable		 4fr0A-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 409
HIS A 405
SER A 448
HIS A 596
LEU A 412
 None
 1.33A 4pooA-6faeA:
undetectable		 4pooA-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
 None
 1.01A 4uw0A-6faeB:
2.0		 4uw0A-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 6 GLU B 113
PHE B  82
GLU B 106
VAL B  23
 None
 1.16A 5h4dA-6faeB:
4.7		 5h4dA-6faeB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A 481
VAL A 521
ILE A 530
ILE A 581
ILE A 537
 None
 1.13A 5hw8D-6faeA:
undetectable		 5hw8D-6faeA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A 494
PRO B  47
ASN B  52
 None
 1.07A 5jwaA-6faeA:
undetectable
5jwaH-6faeA:
undetectable		 5jwaA-6faeA:
undetectable
5jwaH-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA A 534
LEU A 590
ILE B  49
ARG A 494
VAL A 502
 None
 1.30A 5vlmE-6faeA:
undetectable		 5vlmE-6faeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 9 LEU B  34
MET B  22
VAL B  65
SER B 174
ILE B  20
 None
 1.14A 6fdyU-6faeB:
undetectable		 6fdyU-6faeB:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A 696
PHE A 721
SER A 723
LEU A 725
ILE A 729
 None
 1.38A 6fdyU-6faeA:
undetectable		 6fdyU-6faeA:
14.71