SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 VAL B 157
GLU B  51
ILE B  48
LEU B 114
ILE B 148
 None
 1.06A 1d1gB-6fahB:
undetectable		 1d1gB-6fahB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		3 / 3 ASP A 277
ASP A 355
ASP A 275
 None
 0.68A 1ej0A-6fahA:
2.1		 1ej0A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 SER B 189
VAL B 190
GLY B 191
GLY C  48
LEU C  58
 None
 0.91A 1fduA-6fahB:
2.7		 1fduA-6fahB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii;
Acetobacterium
woodii) 		4 / 7 GLY A 218
ASP B  94
SER A 219
ALA B  97
 None
FAD  B 301 (-4.0A)
None
None
 0.95A 1gxsA-6fahA:
2.6
1gxsB-6fahA:
1.6		 1gxsA-6fahA:
undetectable
1gxsB-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		3 / 4 LYS C 170
ALA C 169
MET C 136
 None
 1.04A 1hk3A-6fahC:
undetectable		 1hk3A-6fahC:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 VAL B 112
CYH B  74
LEU B  75
ALA B  79
ALA B   7
 None
 1.05A 1sa1A-6fahB:
undetectable
1sa1B-6fahB:
undetectable		 1sa1A-6fahB:
10.73
1sa1B-6fahB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 VAL B 112
CYH B  74
LEU B  75
ALA B  79
ALA B   7
 None
 1.02A 1sa1C-6fahB:
undetectable
1sa1D-6fahB:
undetectable		 1sa1C-6fahB:
10.73
1sa1D-6fahB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 4 SER A 145
ILE A 148
VAL A 179
THR B  95
 None
None
None
FAD  B 301 (-2.7A)
 0.99A 1u70A-6fahA:
2.2		 1u70A-6fahA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 5 TYR A 155
TYR A 129
ILE A 107
GLY A 153
 None
 1.34A 1ve9A-6fahA:
2.7		 1ve9A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 5 TYR A 155
TYR A 129
ILE A 107
GLY A 153
 None
 1.38A 2du8J-6fahA:
3.0		 2du8J-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 GLY B  78
ALA B  79
ASP B  80
VAL B   5
VAL B  47
 None
 1.05A 2f8gA-6fahB:
undetectable		 2f8gA-6fahB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 LEU C  13
MET C   9
ILE B 193
SER C  61
LEU B  42
 None
 0.95A 2lbdA-6fahC:
undetectable		 2lbdA-6fahC:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 7 LEU A 298
PHE A 278
PHE A 337
ILE A 387
 None
 0.97A 2opxA-6fahA:
undetectable		 2opxA-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		4 / 5 LEU B  71
ILE B 203
SER B  86
GLY B  63
 None
 0.98A 2otfA-6fahB:
undetectable		 2otfA-6fahB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 7 SER C  67
ILE C  10
PRO C  55
GLY C  62
 None
 0.99A 2y7kA-6fahC:
undetectable		 2y7kA-6fahC:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		5 / 12 GLY A 285
ILE A 368
GLY A 343
HIS A 347
LEU A 380
 FAD  A 401 (-3.7A)
None
FAD  A 401 ( 4.9A)
FAD  A 401 (-4.2A)
FAD  A 401 (-4.2A)
 1.17A 3eeyF-6fahA:
undetectable		 3eeyF-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 10 ALA B  41
LEU B 176
ILE B 150
LEU B 172
ILE B   3
 None
 0.94A 3jw3A-6fahB:
undetectable		 3jw3A-6fahB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		3 / 3 ASN C 310
ASP C 239
ARG C 178
 None
 0.59A 3k13A-6fahC:
undetectable		 3k13A-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 8 GLU A 364
LYS A 362
ASN A 361
ASN A 365
 None
FAD  A 401 (-4.7A)
FAD  A 401 (-2.9A)
None
 1.28A 3kp6A-6fahA:
undetectable
3kp6B-6fahA:
undetectable		 3kp6A-6fahA:
16.88
3kp6B-6fahA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 6 ASN A 365
GLU A 364
LYS A 362
ASN A 361
 None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-2.9A)
 1.40A 3kp6A-6fahA:
undetectable
3kp6B-6fahA:
undetectable		 3kp6A-6fahA:
16.88
3kp6B-6fahA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		5 / 12 PRO C  55
GLY C  60
GLY C  59
VAL C 166
LEU C 120
 None
 1.07A 3m6wA-6fahC:
undetectable		 3m6wA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 10 GLY B  78
ALA B  79
ASP B  80
VAL B   5
VAL B  47
 None
 1.02A 3oxwA-6fahB:
undetectable		 3oxwA-6fahB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 GLY B  78
ALA B  79
ASP B  80
VAL B   5
VAL B  47
 None
 1.06A 3oxxA-6fahB:
undetectable		 3oxxA-6fahB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 6 THR A 327
GLN A 326
TYR C 346
ILE C 343
 FAD  A 401 (-4.0A)
None
FAD  A 401 ( 4.7A)
FAD  A 401 ( 4.3A)
 1.11A 3peoG-6fahA:
undetectable		 3peoG-6fahA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 5 LYS A  60
THR A  39
ILE A  61
PHE A  22
 None
SF4  A 403 (-4.6A)
None
None
 1.03A 3tf1A-6fahA:
undetectable		 3tf1A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 5 ASP C 286
THR C 289
GLU C 328
LYS C 332
 SO4  C 404 (-3.0A)
None
None
None
 1.21A 4a3pA-6fahC:
undetectable		 4a3pA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii;
Acetobacterium
woodii) 		3 / 3 TYR B 165
THR A 266
GLU A 262
 None
 0.83A 4df3A-6fahB:
3.5		 4df3A-6fahB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii;
Acetobacterium
woodii) 		3 / 3 TYR B 165
THR A 266
GLU A 262
 None
 0.81A 4df3B-6fahB:
undetectable		 4df3B-6fahB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 7 VAL C 166
ILE C 184
LEU C  58
LEU C 110
 None
 1.03A 4l1wA-6fahC:
undetectable		 4l1wA-6fahC:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 5 ASN C  90
LEU C  86
SER C  88
LEU C  41
 None
 1.06A 4n09C-6fahC:
undetectable		 4n09C-6fahC:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 6 TRP B  96
GLY A 218
ILE A  61
PHE A  22
 None
 1.09A 4qogA-6fahB:
undetectable
4qogB-6fahB:
undetectable		 4qogA-6fahB:
18.18
4qogB-6fahB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		5 / 9 ALA A 344
SER A 354
GLY A 350
ALA A 349
VAL A 371
 FAD  A 401 (-3.5A)
None
None
None
None
 1.20A 4r1zA-6fahA:
undetectable		 4r1zA-6fahA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		5 / 9 ALA A 344
SER A 354
ILE A 357
GLY A 350
ALA A 349
 FAD  A 401 (-3.5A)
None
None
None
None
 1.17A 4r1zA-6fahA:
undetectable		 4r1zA-6fahA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		4 / 6 ALA A 307
GLY A 325
SER A 354
ILE A 279
 None
FAD  A 401 (-3.3A)
None
None
 0.82A 4r21A-6fahA:
undetectable		 4r21A-6fahA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 LEU B 176
ILE B 148
ALA B 155
ILE B  48
MET B   1
 None
 1.24A 4rp8C-6fahB:
undetectable		 4rp8C-6fahB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 CYH B  74
LEU B  34
ASN B  40
VAL B  59
ALA B   7
 None
 0.89A 4x1kD-6fahB:
undetectable		 4x1kD-6fahB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		5 / 12 CYH B  74
LEU B  34
ASN B  40
VAL B  59
ALA B   7
 None
 0.85A 4x1yD-6fahB:
undetectable		 4x1yD-6fahB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii) 		4 / 6 GLY B 192
ASP B 195
GLY B  78
ARG B  72
 None
 1.02A 4z53A-6fahB:
undetectable
4z53B-6fahB:
undetectable		 4z53A-6fahB:
7.28
4z53B-6fahB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 7 ASP C 210
ILE C 212
GLY C 151
THR C 154
 None
 1.13A 4zxiA-6fahC:
undetectable		 4zxiA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD
(Acetobacterium
woodii;
Acetobacterium
woodii) 		4 / 7 TYR A 374
GLY B 250
SER B 254
LEU B 256
 None
 1.19A 5bphB-6fahA:
3.8		 5bphB-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 6 TYR C 299
GLY C 251
GLU C  73
ASP C 258
 None
 1.35A 5emlA-6fahC:
undetectable		 5emlA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 4 ASN C  90
LEU C  86
SER C  88
LEU C  41
 None
 0.97A 5kb5A-6fahC:
undetectable		 5kb5A-6fahC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		3 / 3 SER C  83
SER C  87
PHE C 358
 None
SO4  C 406 (-2.9A)
None
 0.88A 5mugA-6fahC:
undetectable		 5mugA-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		5 / 12 GLU C 349
LEU C 203
GLY C 202
THR C 359
ALA C  82
 None
None
None
SO4  C 403 ( 4.2A)
None
 1.10A 5x5qB-6fahC:
undetectable		 5x5qB-6fahC:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 8 ILE C  40
PHE C  47
LEU C  13
ALA C  14
 None
 0.88A 5y7pC-6fahC:
undetectable		 5y7pC-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 6 MET C   1
ALA C 318
LEU C 297
ALA C 294
 None
 1.20A 6fosB-6fahC:
3.4		 6fosB-6fahC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE
(Acetobacterium
woodii) 		5 / 12 ILE A 341
TYR A 336
THR A 305
ILE A 273
PHE A 292
 FAD  A 401 (-4.1A)
None
None
None
None
 1.42A 6j20A-6fahA:
undetectable		 6j20A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 4 ASP C 164
ILE C 113
PRO C  89
LEU C 120
 None
 1.33A 6mkeB-6fahC:
undetectable		 6mkeB-6fahC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
(Acetobacterium
woodii) 		4 / 4 ASP C 164
ILE C 113
PRO C  89
LEU C 120
 None
 1.36A 6mkeA-6fahC:
undetectable		 6mkeA-6fahC:
20.24