SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG i 305
TYR i 260
LYS i 264
 C  21216 ( 3.7A)
None
C  21216 ( 4.8A)
 0.96A 1uujB-6faii:
undetectable		 1uujB-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		3 / 3 ASP l  81
ARG l 126
ASP l   4
 None
 0.97A 1vptA-6fail:
undetectable		 1vptA-6fail:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP i 417
ARG i 411
PHE i 364
 None
 1.08A 1zeaH-6faii:
undetectable
1zeaL-6faii:
undetectable		 1zeaH-6faii:
undetectable
1zeaL-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL i 307
LEU i 283
ILE i 337
GLY i 339
ALA i 338
 None
None
U  21269 ( 3.8A)
None
None
 1.08A 2aylB-6faii:
undetectable		 2aylB-6faii:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA i 420
PHE i 421
ALA i 425
LEU i 460
 None
 0.94A 2bxmA-6faii:
2.6		 2bxmA-6faii:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 ALA i 420
TYR i 393
ILE i 416
ILE i 372
 None
 1.08A 2dcfA-6faii:
undetectable		 2dcfA-6faii:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU i 382
LEU i 356
ASP i 389
ASP i 388
 None
 1.08A 2j2pA-6faii:
undetectable
2j2pB-6faii:
undetectable		 2j2pA-6faii:
15.57
2j2pB-6faii:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		3 / 3 TYR l 170
GLU l 190
ASN l 118
 None
 0.99A 2y7hC-6fail:
2.1		 2y7hC-6fail:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ALA i 420
TYR i 393
ILE i 416
ILE i 372
 None
 1.04A 2zm7A-6faii:
undetectable		 2zm7A-6faii:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		4 / 7 ILE l 235
PHE l 174
LYS l 175
GLY l 248
 None
 1.09A 3em0B-6fail:
undetectable		 3em0B-6fail:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		4 / 7 TYR l 210
LYS l 281
GLU l 287
PRO l 288
 None
 1.25A 3hs4A-6fail:
undetectable		 3hs4A-6fail:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 PRO i 237
PHE i 278
ALA i 262
 None
 0.62A 3itaD-6faii:
undetectable		 3itaD-6faii:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL i 307
LEU i 283
ILE i 337
GLY i 339
ALA i 338
 None
None
U  21269 ( 3.8A)
None
None
 1.07A 3kk6A-6faii:
undetectable		 3kk6A-6faii:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU i 359
VAL i 326
LEU i 325
PHE i 323
LEU i 299
 None
None
None
None
U  21269 ( 4.5A)
 1.29A 3w67D-6faii:
undetectable		 3w67D-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		4 / 5 GLU j 369
GLY j 367
TYR j 371
GLN i 276
 None
 1.50A 3w9tD-6faij:
undetectable		 3w9tD-6faij:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		4 / 5 GLU j 369
GLY j 367
TYR j 371
GLN i 276
 None
 1.49A 3w9tE-6faij:
undetectable		 3w9tE-6faij:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		4 / 5 GLU j 369
GLY j 367
TYR j 371
GLN i 276
 None
 1.49A 3w9tG-6faij:
undetectable		 3w9tG-6faij:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		3 / 3 ASP l  81
ARG l 126
ASP l   4
 None
 0.89A 4fp9D-6fail:
undetectable		 4fp9D-6fail:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU i 311
GLY i 339
ALA i 343
PHE i 371
LEU i 359
 None
None
G  21267 ( 3.2A)
None
None
 1.21A 4hytA-6faii:
undetectable		 4hytA-6faii:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LYS i 264
LEU i 265
GLU i 261
LEU i 229
 C  21216 ( 4.8A)
None
None
None
 1.17A 4k4yA-6faii:
1.8		 4k4yA-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 LYS i 264
LEU i 265
GLU i 261
LEU i 229
 C  21216 ( 4.8A)
None
None
None
 1.19A 4k4yE-6faii:
1.5		 4k4yE-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LYS i 264
LEU i 265
GLU i 261
LEU i 229
 C  21216 ( 4.8A)
None
None
None
 1.22A 4k4yI-6faii:
1.8		 4k4yI-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER i 352
TYR i 380
PRO i 314
 None
 0.83A 4kbeB-6faii:
undetectable		 4kbeB-6faii:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU i 311
GLY i 339
ALA i 343
PHE i 371
LEU i 359
 None
None
G  21267 ( 3.2A)
None
None
 1.18A 4retA-6faii:
undetectable		 4retA-6faii:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU i 311
GLY i 339
ALA i 343
PHE i 371
LEU i 359
 None
None
G  21267 ( 3.2A)
None
None
 1.17A 4retC-6faii:
undetectable		 4retC-6faii:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU i 459
PHE i 424
LYS i 429
TYR i 428
 None
 1.40A 4uciB-6faii:
undetectable		 4uciB-6faii:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		4 / 7 ASN l 205
LYS l 208
TYR l 210
PHE l 174
 None
 1.25A 4yv5A-6fail:
undetectable		 4yv5A-6fail:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		5 / 11 PHE i 318
GLY j 367
LEU i 382
LEU i 356
THR i 386
 None
 1.15A 4zmeA-6faii:
undetectable		 4zmeA-6faii:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		4 / 5 GLY i 320
TYR i 358
TYR j 371
GLY j 367
 None
 0.84A 5ayfA-6faii:
undetectable		 5ayfA-6faii:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		4 / 6 SER l  41
GLY l  48
MET l  43
ILE l  53
 None
 1.16A 5j4nA-6fail:
undetectable		 5j4nA-6fail:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2
(Saccharomyces
cerevisiae) 		4 / 5 VAL l  94
LEU l  85
HIS l 185
THR l   5
 None
 1.28A 6dyoA-6fail:
undetectable		 6dyoA-6fail:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 6fai ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLN i 276
GLY i 320
PHE i 321
VAL i 326
 None
 1.05A 6hu9S-6faii:
undetectable
6hu9q-6faii:
undetectable		 6hu9S-6faii:
undetectable
6hu9q-6faii:
undetectable