SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1828
PRO A1820
THR A1826
 None
 0.87A 1a7yB-6fb3A:
undetectable		 1a7yB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 10 GLY A2009
SER A2007
PHE A2649
LEU A2703
HIS A2647
 None
 1.31A 1a8uB-6fb3A:
undetectable		 1a8uB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 LEU A2274
TYR A2276
ASN A2491
TYR A2422
 None
 1.40A 1afsA-6fb3A:
undetectable		 1afsA-6fb3A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 LEU A2274
TYR A2276
ASN A2491
TYR A2422
 None
 1.39A 1afsB-6fb3A:
undetectable		 1afsB-6fb3A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 GLU A2583
ILE A2581
ARG A1928
 None
 0.65A 1cd2A-6fb3A:
undetectable		 1cd2A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1828
PRO A1820
THR A1826
 None
 0.84A 1dscC-6fb3A:
undetectable		 1dscC-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 GLN A2455
PHE A2297
PHE A2039
PHE A2026
 None
 1.20A 1e71M-6fb3A:
undetectable		 1e71M-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 GLN A2455
PHE A2297
PHE A2039
PHE A2026
 None
 1.22A 1e72M-6fb3A:
undetectable		 1e72M-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 ARG A1406
ALA A1378
ASP A1374
GLY A1376
 None
 1.07A 1e7cA-6fb3A:
undetectable		 1e7cA-6fb3A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 ARG A1596
ALA A1566
ASP A1562
GLY A1564
 None
 1.14A 1e7cA-6fb3A:
undetectable		 1e7cA-6fb3A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.84A 1fjaC-6fb3A:
undetectable		 1fjaC-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.84A 1fjaD-6fb3A:
undetectable		 1fjaD-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 TYR A1962
LEU A1972
LEU A1971
SER A1961
LEU A1965
 None
 1.31A 1fmlA-6fb3A:
undetectable		 1fmlA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.85A 1i3wE-6fb3A:
undetectable		 1i3wE-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.83A 1i3wF-6fb3A:
undetectable		 1i3wF-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.86A 1i3wH-6fb3A:
undetectable		 1i3wH-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 THR A1773
SER A1784
THR A1786
VAL A1788
 None
 0.44A 1ictD-6fb3A:
undetectable		 1ictD-6fb3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.80A 1mnvD-6fb3A:
undetectable		 1mnvD-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1828
PRO A1820
THR A1826
 None
 0.81A 1ovfB-6fb3A:
undetectable		 1ovfB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1826
THR A1828
PRO A1820
 None
 0.84A 1qfiA-6fb3A:
undetectable		 1qfiA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 VAL A1637
THR A1638
GLN A2571
ILE A1899
 None
 1.22A 1ss4A-6fb3A:
1.1		 1ss4A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 LEU A2313
GLY A2334
LEU A2082
ILE A2059
 None
 0.82A 1yajF-6fb3A:
undetectable		 1yajF-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 CYH A2545
PRO A2098
THR A2540
SER A2542
 None
 1.47A 1ymxA-6fb3A:
undetectable		 1ymxA-6fb3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 TRP A2753
GLU A2757
TYR A2770
 None
 1.19A 2a3aA-6fb3A:
undetectable		 2a3aA-6fb3A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 TYR A1317
PHE A1280
ALA A1588
ILE A1299
LEU A1265
 None
 1.04A 2bjfA-6fb3A:
undetectable		 2bjfA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A1477
ARG A1054
SER A1475
LEU A1448
ILE A1405
 None
 1.06A 2h79A-6fb3A:
undetectable		 2h79A-6fb3A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 SER A1506
ALA A1507
SER A1519
SER A1575
 None
 0.85A 2i91A-6fb3A:
undetectable		 2i91A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 SER A1506
ALA A1507
SER A1519
SER A1575
 None
 0.85A 2i91B-6fb3A:
undetectable		 2i91B-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 SER A2787
LEU A2784
SER A2789
ASP A2062
 None
 1.22A 2j2pE-6fb3A:
undetectable
2j2pF-6fb3A:
undetectable		 2j2pE-6fb3A:
15.31
2j2pF-6fb3A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 ARG A2094
ASP A2118
THR A2120
ILE A2096
 None
 1.19A 2jc9A-6fb3A:
undetectable		 2jc9A-6fb3A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 4 ALA A2631
VAL A2627
PHE A2649
THR A2611
 None
 1.36A 2pkkA-6fb3A:
undetectable		 2pkkA-6fb3A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 LEU A1137
PRO A1025
VAL A1022
MET A1453
 None
 1.12A 2qd2A-6fb3A:
undetectable		 2qd2A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 GLU A2559
GLY A2548
ILE A1814
PHE A2126
 None
 0.98A 2qmzA-6fb3A:
undetectable
2qmzB-6fb3A:
undetectable		 2qmzA-6fb3A:
19.56
2qmzB-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.79A 2qmzA-6fb3A:
undetectable
2qmzB-6fb3A:
undetectable		 2qmzA-6fb3A:
19.56
2qmzB-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.82A 2qr2A-6fb3A:
undetectable
2qr2B-6fb3A:
undetectable		 2qr2A-6fb3A:
19.56
2qr2B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.94A 2qr2A-6fb3A:
undetectable
2qr2B-6fb3A:
undetectable		 2qr2A-6fb3A:
19.56
2qr2B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 TRP A2465
GLY A2423
PHE A2532
PHE A2453
 None
 0.73A 2qr2A-6fb3A:
undetectable
2qr2B-6fb3A:
undetectable		 2qr2A-6fb3A:
19.56
2qr2B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 TRP A2465
GLY A2423
PHE A2532
PHE A2453
 None
 0.91A 2qr2A-6fb3A:
undetectable
2qr2B-6fb3A:
undetectable		 2qr2A-6fb3A:
19.56
2qr2B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.79A 2qwxA-6fb3A:
undetectable
2qwxB-6fb3A:
undetectable		 2qwxA-6fb3A:
19.47
2qwxB-6fb3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 TRP A2465
GLY A2423
PHE A2532
PHE A2453
 None
 0.92A 2qwxA-6fb3A:
undetectable
2qwxB-6fb3A:
undetectable		 2qwxA-6fb3A:
19.47
2qwxB-6fb3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.78A 2qx4A-6fb3A:
undetectable
2qx4B-6fb3A:
undetectable		 2qx4A-6fb3A:
19.56
2qx4B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.78A 2qx6A-6fb3A:
undetectable
2qx6B-6fb3A:
undetectable		 2qx6A-6fb3A:
19.56
2qx6B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 TRP A2465
GLY A2423
PHE A2532
PHE A2453
 None
 0.80A 2qx6A-6fb3A:
undetectable
2qx6B-6fb3A:
undetectable		 2qx6A-6fb3A:
19.56
2qx6B-6fb3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 ASN A2257
ASN A2484
ARG A2464
 None
 0.89A 2rlcA-6fb3A:
undetectable		 2rlcA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A2059
TYR A2048
VAL A2046
ASN A2309
PHE A2068
 None
 1.33A 3a8iA-6fb3A:
undetectable		 3a8iA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A2059
TYR A2048
VAL A2046
ASN A2309
PHE A2068
 None
 1.38A 3a8iB-6fb3A:
undetectable		 3a8iB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A2059
TYR A2048
VAL A2046
ASN A2309
PHE A2068
 None
 1.44A 3a8iC-6fb3A:
undetectable		 3a8iC-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A2059
TYR A2048
VAL A2046
ASN A2309
PHE A2068
 None
 1.43A 3a8iD-6fb3A:
undetectable		 3a8iD-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A1905
LEU A1634
SER A1635
SER A1659
TYR A1643
 None
 1.41A 3bxoB-6fb3A:
undetectable		 3bxoB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 TYR A2105
ILE A2131
TYR A2119
THR A2120
 None
 1.19A 3dgqA-6fb3A:
undetectable		 3dgqA-6fb3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A1706
ILE A2616
GLY A2599
LEU A1697
THR A1709
 None
 1.18A 3eeyH-6fb3A:
undetectable		 3eeyH-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ASN A1421
ASP A1374
ILE A1414
GLY A1376
THR A1382
 None
 1.02A 3eeyJ-6fb3A:
undetectable		 3eeyJ-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 10 GLY A1359
ALA A1381
ASP A1380
GLY A1412
THR A1416
 None
 1.04A 3el9B-6fb3A:
undetectable		 3el9B-6fb3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 TYR A2774
VAL A2778
TYR A2639
THR A2646
 None
 1.03A 3gssA-6fb3A:
undetectable		 3gssA-6fb3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_B_LLLB500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 11 ASP A2786
SER A2787
SER A2310
ASP A2295
ARG A2012
 None
 1.09A 3hamB-6fb3A:
0.0		 3hamB-6fb3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ASP A2499
ASP A1956
ASP A2236
TRP A1960
 None
 1.25A 3havA-6fb3A:
2.7		 3havA-6fb3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 TYR A2105
GLN A2103
ILE A2128
PHE A2117
 None
 1.27A 3ls4L-6fb3A:
undetectable		 3ls4L-6fb3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 SER A1102
GLN A1195
PHE A1231
HIS A1223
 None
 1.18A 3lskB-6fb3A:
undetectable		 3lskB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 SER A1102
GLN A1195
PHE A1231
HIS A1223
 None
 1.18A 3lskD-6fb3A:
undetectable		 3lskD-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 11 HIS A1630
HIS A1213
ALA A1824
LEU A1621
THR A1633
 None
 1.22A 3mdzA-6fb3A:
undetectable		 3mdzA-6fb3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 ILE A2521
ILE A2167
GLY A2515
VAL A2507
 None
 0.86A 3n3iA-6fb3A:
undetectable		 3n3iA-6fb3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ARG A2335
LEU A2077
ILE A2091
GLY A2332
LEU A2539
 None
 1.16A 3n8xA-6fb3A:
undetectable		 3n8xA-6fb3A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ALA A1566
GLY A1543
GLY A1561
SER A1560
ASP A1563
 None
 1.20A 3ou7A-6fb3A:
undetectable		 3ou7A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ALA A1566
GLY A1543
GLY A1561
SER A1560
ASP A1563
 None
 1.18A 3ou7D-6fb3A:
undetectable		 3ou7D-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A2186
GLY A2211
VAL A2205
ALA A1936
ASP A1956
 None
 1.19A 3qowA-6fb3A:
undetectable		 3qowA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 LEU A1516
GLY A1479
ILE A1477
ILE A1538
ILE A1476
 None
 0.99A 3uj6A-6fb3A:
undetectable		 3uj6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 SER A1094
ASP A1681
ASP A1944
ILE A1943
 None
 1.27A 3uj7B-6fb3A:
undetectable		 3uj7B-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 LEU A2511
MET A2513
ASP A2166
 None
 0.78A 3v5wA-6fb3A:
2.6		 3v5wA-6fb3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 TYR A2010
ASP A2645
ARG A2730
HIS A2647
 None
 1.43A 3zodA-6fb3A:
undetectable		 3zodA-6fb3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ILE A1465
ILE A1477
SER A1780
GLY A1536
 None
 0.81A 4acaC-6fb3A:
undetectable		 4acaC-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ILE A1465
ILE A1477
SER A1780
GLY A1536
 None
 0.82A 4acbC-6fb3A:
undetectable		 4acbC-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 ASP A1200
SER A1202
TYR A1647
HIS A1212
 None
 1.17A 4arcA-6fb3A:
undetectable		 4arcA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 SER A1202
TYR A1647
HIS A1630
HIS A1212
 None
 1.38A 4arcA-6fb3A:
undetectable		 4arcA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.79A 4fgjA-6fb3A:
undetectable
4fgjB-6fb3A:
undetectable		 4fgjA-6fb3A:
undetectable
4fgjB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 GLY A1583
VAL A1579
PRO A1581
GLY A1003
 None
 0.51A 4forA-6fb3A:
undetectable		 4forA-6fb3A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 ARG A2336
HIS A2452
TYR A2328
 None
 1.18A 4fu8A-6fb3A:
undetectable		 4fu8A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 ARG A2336
HIS A2452
TYR A2328
 None
 1.13A 4fu9A-6fb3A:
undetectable		 4fu9A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1828
PRO A1820
THR A1826
 None
 0.86A 4hivD-6fb3A:
undetectable		 4hivD-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 11 LEU A1971
LEU A2577
TRP A1960
TYR A1962
ALA A2481
 None
 1.38A 4hwkB-6fb3A:
undetectable		 4hwkB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 THR A1773
SER A1784
THR A1786
VAL A1788
 None
 0.62A 4ik7B-6fb3A:
undetectable		 4ik7B-6fb3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 10 VAL A1653
TYR A1647
HIS A1212
VAL A1666
LEU A1199
 None
 1.43A 4jq4A-6fb3A:
undetectable		 4jq4A-6fb3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 LEU A1137
PRO A1025
VAL A1022
MET A1453
 None
 1.18A 4klrA-6fb3A:
undetectable		 4klrA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 PRO A1912
SER A1913
VAL A2504
TRP A2510
 None
 1.49A 4kmmA-6fb3A:
undetectable		 4kmmA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 LYS A2291
TYR A2290
ILE A2282
LEU A2461
GLY A2463
 None
 1.16A 4l9qB-6fb3A:
undetectable		 4l9qB-6fb3A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 ILE A1943
MET A1953
ARG A1940
 None
None
NAG  A3016 (-3.4A)
 0.90A 4lnwA-6fb3A:
undetectable		 4lnwA-6fb3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 ILE A1943
MET A1953
ARG A1940
 None
None
NAG  A3016 (-3.4A)
 0.91A 4lnxA-6fb3A:
undetectable		 4lnxA-6fb3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 GLY A2161
ILE A2170
LYS A2180
GLN A2169
 None
 1.21A 4ma8C-6fb3A:
undetectable		 4ma8C-6fb3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 SER A1846
ARG A1833
HIS A1817
 NAG  A3014 (-3.0A)
NAG  A3014 (-3.8A)
NAG  A3014 (-4.1A)
 1.02A 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable		 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.76A 4qogA-6fb3A:
undetectable
4qogB-6fb3A:
undetectable		 4qogA-6fb3A:
19.47
4qogB-6fb3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 PHE A2532
PHE A2453
TRP A2465
GLY A2423
 None
 0.74A 4qoiA-6fb3A:
undetectable
4qoiB-6fb3A:
undetectable		 4qoiA-6fb3A:
19.47
4qoiB-6fb3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		6 / 12 GLY A2441
GLY A2442
ILE A2188
ASN A2399
TYR A2376
GLN A2169
 None
 1.31A 4rtmA-6fb3A:
undetectable		 4rtmA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1749
ASN A1765
SER A1766
 None
 0.76A 4tvtA-6fb3A:
undetectable		 4tvtA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ALA A1272
ALA A1449
ALA A1509
ALA A1578
 None
 0.73A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ALA A1449
ALA A1509
ALA A1578
ALA A1272
 None
 0.77A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ALA A1509
ALA A1578
ALA A1272
ALA A1449
 None
 0.79A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 ALA A1578
ALA A1272
ALA A1449
ALA A1509
 None
 0.79A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 GLY A1196
TYR A1107
SER A1109
SER A1065
 None
 1.04A 4wryA-6fb3A:
undetectable		 4wryA-6fb3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 GLY A1196
TYR A1107
SER A1109
SER A1065
 None
 1.02A 4wrzA-6fb3A:
undetectable		 4wrzA-6fb3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 GLY A1196
TYR A1107
SER A1109
SER A1065
 None
 1.03A 4ws1A-6fb3A:
undetectable		 4ws1A-6fb3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 LEU A2347
GLU A2370
ILE A2437
PRO A2133
 NAG  A3001 ( 4.6A)
None
None
None
 1.07A 4xi3C-6fb3A:
undetectable		 4xi3C-6fb3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 ARG A1289
GLY A1346
SER A1343
LEU A1344
 None
 1.22A 5bphA-6fb3A:
undetectable		 5bphA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 TYR A2351
GLY A2332
SER A2084
ILE A2059
VAL A2046
 None
 1.15A 5dpdB-6fb3A:
undetectable		 5dpdB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 4 ALA A1449
PRO A1323
LEU A1024
HIS A1512
 None
 1.47A 5eskA-6fb3A:
undetectable		 5eskA-6fb3A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 SER A2038
PHE A2039
GLY A2041
PHE A2047
 None
 0.95A 5flcB-6fb3A:
undetectable		 5flcB-6fb3A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 SER A2038
PHE A2039
GLY A2041
PHE A2047
 None
 0.94A 5flcF-6fb3A:
undetectable		 5flcF-6fb3A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 TYR A2330
ILE A2282
GLY A2463
LEU A2450
HIS A2452
 None
 1.19A 5fsaA-6fb3A:
undetectable		 5fsaA-6fb3A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ILE A1604
ALA A1542
ALA A1566
LEU A1541
TYR A1586
 None
 1.09A 5igpA-6fb3A:
undetectable		 5igpA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 TYR A2010
GLY A2009
THR A1745
LEU A2704
 None
 0.91A 5jlcA-6fb3A:
undetectable		 5jlcA-6fb3A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A2401
LEU A2494
ALA A2421
PHE A2488
LYS A2489
 None
 1.24A 5kc4E-6fb3A:
undetectable		 5kc4E-6fb3A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 LEU A1084
TYR A1107
LEU A1738
TYR A1732
 None
 1.50A 5ki6A-6fb3A:
undetectable		 5ki6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 THR A1584
SER A1599
ASP A1562
 None
 0.82A 5kvaB-6fb3A:
undetectable		 5kvaB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 10 GLY A1694
GLY A1205
LEU A1707
VAL A1698
LEU A1697
 None
 0.89A 5o96G-6fb3A:
undetectable
5o96H-6fb3A:
undetectable		 5o96G-6fb3A:
undetectable
5o96H-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 ALA A2317
PHE A2350
TYR A2364
ALA A2115
THR A2315
 None
 1.07A 5tl8A-6fb3A:
undetectable		 5tl8A-6fb3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 LEU A1973
LEU A1972
GLN A2238
TYR A2254
 None
 1.42A 5uc3A-6fb3A:
undetectable		 5uc3A-6fb3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 VAL A2242
TYR A2426
LEU A2404
ARG A2216
 None
 1.11A 5umwB-6fb3A:
undetectable
5umwE-6fb3A:
2.2		 5umwB-6fb3A:
21.43
5umwE-6fb3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 7 LEU A2404
ARG A2216
VAL A2242
TYR A2426
 None
 1.31A 5umwA-6fb3A:
2.4
5umwF-6fb3A:
1.7		 5umwA-6fb3A:
21.43
5umwF-6fb3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 GLY A1073
ILE A1098
TRP A1207
ASP A1070
 None
 1.04A 5vlmH-6fb3A:
undetectable		 5vlmH-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 ARG A2301
LEU A2298
PHE A2297
LEU A2450
 None
 1.19A 5x1fC-6fb3A:
undetectable
5x1fJ-6fb3A:
undetectable		 5x1fC-6fb3A:
undetectable
5x1fJ-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 ARG A2301
LEU A2298
PHE A2297
LEU A2450
 None
 1.25A 5xdxC-6fb3A:
undetectable
5xdxJ-6fb3A:
undetectable		 5xdxC-6fb3A:
undetectable
5xdxJ-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 5 ARG A2301
LEU A2298
PHE A2297
LEU A2450
 None
 1.26A 5xdxP-6fb3A:
undetectable
5xdxW-6fb3A:
undetectable		 5xdxP-6fb3A:
undetectable
5xdxW-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A2237
GLY A2258
ASN A2492
LEU A2498
ASP A2236
 None
 1.34A 5yn6A-6fb3A:
undetectable		 5yn6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A2237
GLY A2258
ASN A2492
LEU A2498
ASP A2236
 None
 1.34A 5yniA-6fb3A:
undetectable		 5yniA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 GLY A2237
GLY A2258
ASN A2492
LEU A2498
ASP A2236
 None
 1.32A 5ynmA-6fb3A:
undetectable		 5ynmA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 GLU A1886
TRP A1910
ILE A2573
PRO A1907
 None
 0.80A 6a4iA-6fb3A:
undetectable		 6a4iA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 4 PRO A1292
MET A1243
GLY A1262
VAL A1296
 None
 1.38A 6ak3A-6fb3A:
undetectable		 6ak3A-6fb3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 9 PHE A2453
GLY A2442
LEU A2539
ARG A2359
ASP A2353
 None
 1.21A 6c2mC-6fb3A:
undetectable		 6c2mC-6fb3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 6 ASN A1794
TYR A1808
LYS A2055
VAL A2076
 None
 1.39A 6f32B-6fb3A:
undetectable		 6f32B-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 6fb3 TENEURIN-2
(Gallus
gallus) 		4 / 8 SER A1093
TYR A1643
GLY A1905
ASN A1662
 None
 1.07A 6giqL-6fb3A:
undetectable
6giqP-6fb3A:
undetectable
6giqT-6fb3A:
undetectable		 6giqL-6fb3A:
undetectable
6giqP-6fb3A:
undetectable
6giqT-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		5 / 12 VAL A1532
ILE A1518
SER A1475
VAL A1464
ILE A1465
 None
 1.37A 6gsdA-6fb3A:
undetectable		 6gsdA-6fb3A:
12.50