SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_N_TRPN81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.01A	1c9sN-6fc0A: undetectable 1c9sO-6fc0A: undetectable	1c9sN-6fc0A: undetectable 1c9sO-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_P_TRPP81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1c9sP-6fc0A: undetectable 1c9sQ-6fc0A: undetectable	1c9sP-6fc0A: undetectable 1c9sQ-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_Q_TRPQ81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 9	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	0.98A	1c9sQ-6fc0A: undetectable 1c9sR-6fc0A: undetectable	1c9sQ-6fc0A: undetectable 1c9sR-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_T_TRPT81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	4 / 7	ALA A 239 HIS A 233 THR A 234 THR A 182	None	0.89A	1c9sT-6fc0A: undetectable 1c9sU-6fc0A: undetectable	1c9sT-6fc0A: undetectable 1c9sU-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_V_TRPV81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	1.02A	1c9sL-6fc0A: 0.6 1c9sV-6fc0A: undetectable	1c9sL-6fc0A: undetectable 1c9sV-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_E_TRPE81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 9	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	1.05A	1gtfD-6fc0A: undetectable 1gtfE-6fc0A: 0.6	1gtfD-6fc0A: undetectable 1gtfE-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_K_TRPK81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.97A	1gtfJ-6fc0A: undetectable 1gtfK-6fc0A: undetectable	1gtfJ-6fc0A: undetectable 1gtfK-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_L_TRPL81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	4 / 7	ALA A 239 HIS A 233 THR A 234 THR A 182	None	0.89A	1gtfL-6fc0A: undetectable 1gtfM-6fc0A: undetectable	1gtfL-6fc0A: undetectable 1gtfM-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_N_TRPN81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	4 / 8	ALA A 239 HIS A 233 THR A 234 THR A 182	None	0.88A	1gtfN-6fc0A: undetectable 1gtfO-6fc0A: undetectable	1gtfN-6fc0A: undetectable 1gtfO-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_Q_TRPQ81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1gtfQ-6fc0A: undetectable 1gtfR-6fc0A: undetectable	1gtfQ-6fc0A: undetectable 1gtfR-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_R_TRPR81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 9	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1gtfR-6fc0A: undetectable 1gtfS-6fc0A: undetectable	1gtfR-6fc0A: undetectable 1gtfS-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_S_TRPS81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1gtfS-6fc0A: undetectable 1gtfT-6fc0A: undetectable	1gtfS-6fc0A: undetectable 1gtfT-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_T_TRPT81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	0.98A	1gtnT-6fc0A: undetectable 1gtnU-6fc0A: undetectable	1gtnT-6fc0A: undetectable 1gtnU-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_V_TRPV81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 12	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	1.03A	1gtnL-6fc0A: undetectable 1gtnV-6fc0A: undetectable	1gtnL-6fc0A: undetectable 1gtnV-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_E_TRPE81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1utdE-6fc0A: undetectable 1utdF-6fc0A: undetectable	1utdE-6fc0A: undetectable 1utdF-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_H_TRPH81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	0.98A	1utdH-6fc0A: 0.6 1utdI-6fc0A: undetectable	1utdH-6fc0A: undetectable 1utdI-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_L_TRPL81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 12	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.01A	1utdL-6fc0A: 0.6 1utdM-6fc0A: undetectable	1utdL-6fc0A: undetectable 1utdM-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_O_TRPO81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 12	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	0.99A	1utdO-6fc0A: undetectable 1utdP-6fc0A: undetectable	1utdO-6fc0A: undetectable 1utdP-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_P_TRPP81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1utdP-6fc0A: undetectable 1utdQ-6fc0A: undetectable	1utdP-6fc0A: undetectable 1utdQ-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_S_TRPS81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.00A	1utdS-6fc0A: undetectable 1utdT-6fc0A: undetectable	1utdS-6fc0A: undetectable 1utdT-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_U_TRPU81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	ALA A 239 HIS A 233 THR A 234 GLY A 123 THR A 182	None	1.02A	1utdU-6fc0A: undetectable 1utdV-6fc0A: undetectable	1utdU-6fc0A: undetectable 1utdV-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_V_TRPV81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 11	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	1.00A	1utdL-6fc0A: undetectable 1utdV-6fc0A: undetectable	1utdL-6fc0A: undetectable 1utdV-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA509_0 (CHORISMATE SYNTHASE)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4G (Chaetomium thermophilum)	3 / 3	ARG B 963 GLN B 954 PRO B 955	None	0.72A	2qhfA-6fc0B: undetectable	2qhfA-6fc0B: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HRD_E_NIOE5660_1 (NICOTINATE DEHYDROGENASE LARGE MOLYBDOPTERIN SUBUNIT NICOTINATE DEHYDROGENASE MEDIUM MOLYBDOPTERIN SUBUNIT)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	3 / 3	GLU A 113 GLU A 115 TRP A 178	None	1.22A	3hrdA-6fc0A: undetectable 3hrdE-6fc0A: undetectable 3hrdF-6fc0A: undetectable	3hrdA-6fc0A: 10.84 3hrdE-6fc0A: 10.84 3hrdF-6fc0A: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UMJ_A_BFQA1298_1 (GERANYLTRANSTRANSFER ASE)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4G (Chaetomium thermophilum)	4 / 4	ILE B 980 PHE B1004 GLN B1003 ASP B1001	None	0.99A	4umjA-6fc0B: undetectable	4umjA-6fc0B: 16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEV_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5eevA-6fc0A: undetectable 5eevB-6fc0A: 0.6	5eevA-6fc0A: undetectable 5eevB-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEW_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5eewA-6fc0A: undetectable 5eewB-6fc0A: 0.6	5eewA-6fc0A: undetectable 5eewB-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEX_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5eexA-6fc0A: undetectable 5eexB-6fc0A: undetectable	5eexA-6fc0A: undetectable 5eexB-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEY_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5eeyA-6fc0A: undetectable 5eeyB-6fc0A: 0.6	5eeyA-6fc0A: undetectable 5eeyB-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEZ_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5eezA-6fc0A: undetectable 5eezB-6fc0A: undetectable	5eezA-6fc0A: undetectable 5eezB-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF0_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5ef0A-6fc0A: 0.6 5ef0B-6fc0A: undetectable	5ef0A-6fc0A: undetectable 5ef0B-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF1_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5ef1A-6fc0A: undetectable 5ef1B-6fc0A: undetectable	5ef1A-6fc0A: undetectable 5ef1B-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF2_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5ef2A-6fc0A: undetectable 5ef2B-6fc0A: undetectable	5ef2A-6fc0A: undetectable 5ef2B-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF3_A_TRPA101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	5 / 10	GLY A 123 THR A 182 ALA A 239 HIS A 233 THR A 234	None	0.99A	5ef3A-6fc0A: undetectable 5ef3B-6fc0A: 0.5	5ef3A-6fc0A: undetectable 5ef3B-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G08_A_Z80A1187_1 (FREQUENIN 2)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN EUKARYOTIC TRANSLATION INITIATION FACTOR 4G (Chaetomium thermophilum)	4 / 6	TYR B1000 PHE B 998 PHE B1008 THR A 35	None	1.30A	5g08A-6fc0B: undetectable	5g08A-6fc0B: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_C_FUAC1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	3 / 3	VAL A 164 HIS A 143 VAL A 219	None	0.37A	5jmnC-6fc0A: 3.0	5jmnC-6fc0A: 6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN EUKARYOTIC TRANSLATION INITIATION FACTOR 4G (Chaetomium thermophilum; Chaetomium thermophilum)	4 / 6	PHE B1004 ASN B 984 LEU B 987 GLY A 150	None	1.05A	5o4yA-6fc0B: undetectable	5o4yA-6fc0B: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TJY_A_BEZA304_0 (4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	3 / 3	MET A 162 GLU A 203 ARG A 180	None	1.08A	5tjyA-6fc0A: undetectable	5tjyA-6fc0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TJZ_A_BEZA302_0 (4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE)	6fc0	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN (Chaetomium thermophilum)	3 / 3	MET A 162 GLU A 203 ARG A 180	None	1.05A	5tjzA-6fc0A: undetectable	5tjzA-6fc0A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C9S_N_TRPN81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.01A","1c9sN-6fc0A:undetectable;1c9sO-6fc0A:undetectable","1c9sN-6fc0A:undetectable;1c9sO-6fc0A:undetectable"],["1C9S_P_TRPP81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1c9sP-6fc0A:undetectable;1c9sQ-6fc0A:undetectable","1c9sP-6fc0A:undetectable;1c9sQ-6fc0A:undetectable"],["1C9S_Q_TRPQ81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","0.98A","1c9sQ-6fc0A:undetectable;1c9sR-6fc0A:undetectable","1c9sQ-6fc0A:undetectable;1c9sR-6fc0A:undetectable"],["1C9S_T_TRPT81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",4,"ALA A 239;HIS A 233;THR A 234;THR A 182","None","0.89A","1c9sT-6fc0A:undetectable;1c9sU-6fc0A:undetectable","1c9sT-6fc0A:undetectable;1c9sU-6fc0A:undetectable"],["1C9S_V_TRPV81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","1.02A","1c9sL-6fc0A:0.6;1c9sV-6fc0A:undetectable","1c9sL-6fc0A:undetectable;1c9sV-6fc0A:undetectable"],["1GTF_E_TRPE81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","1.05A","1gtfD-6fc0A:undetectable;1gtfE-6fc0A:0.6","1gtfD-6fc0A:undetectable;1gtfE-6fc0A:undetectable"],["1GTF_K_TRPK81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.97A","1gtfJ-6fc0A:undetectable;1gtfK-6fc0A:undetectable","1gtfJ-6fc0A:undetectable;1gtfK-6fc0A:undetectable"],["1GTF_L_TRPL81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",4,"ALA A 239;HIS A 233;THR A 234;THR A 182","None","0.89A","1gtfL-6fc0A:undetectable;1gtfM-6fc0A:undetectable","1gtfL-6fc0A:undetectable;1gtfM-6fc0A:undetectable"],["1GTF_N_TRPN81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",4,"ALA A 239;HIS A 233;THR A 234;THR A 182","None","0.88A","1gtfN-6fc0A:undetectable;1gtfO-6fc0A:undetectable","1gtfN-6fc0A:undetectable;1gtfO-6fc0A:undetectable"],["1GTF_Q_TRPQ81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1gtfQ-6fc0A:undetectable;1gtfR-6fc0A:undetectable","1gtfQ-6fc0A:undetectable;1gtfR-6fc0A:undetectable"],["1GTF_R_TRPR81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1gtfR-6fc0A:undetectable;1gtfS-6fc0A:undetectable","1gtfR-6fc0A:undetectable;1gtfS-6fc0A:undetectable"],["1GTF_S_TRPS81_0","TRP RNA-BINDING ATTENUATION PROTEIN (TRAP)","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1gtfS-6fc0A:undetectable;1gtfT-6fc0A:undetectable","1gtfS-6fc0A:undetectable;1gtfT-6fc0A:undetectable"],["1GTN_T_TRPT81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","0.98A","1gtnT-6fc0A:undetectable;1gtnU-6fc0A:undetectable","1gtnT-6fc0A:undetectable;1gtnU-6fc0A:undetectable"],["1GTN_V_TRPV81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","1.03A","1gtnL-6fc0A:undetectable;1gtnV-6fc0A:undetectable","1gtnL-6fc0A:undetectable;1gtnV-6fc0A:undetectable"],["1UTD_E_TRPE81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1utdE-6fc0A:undetectable;1utdF-6fc0A:undetectable","1utdE-6fc0A:undetectable;1utdF-6fc0A:undetectable"],["1UTD_H_TRPH81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","0.98A","1utdH-6fc0A:0.6;1utdI-6fc0A:undetectable","1utdH-6fc0A:undetectable;1utdI-6fc0A:undetectable"],["1UTD_L_TRPL81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.01A","1utdL-6fc0A:0.6;1utdM-6fc0A:undetectable","1utdL-6fc0A:undetectable;1utdM-6fc0A:undetectable"],["1UTD_O_TRPO81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","0.99A","1utdO-6fc0A:undetectable;1utdP-6fc0A:undetectable","1utdO-6fc0A:undetectable;1utdP-6fc0A:undetectable"],["1UTD_P_TRPP81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1utdP-6fc0A:undetectable;1utdQ-6fc0A:undetectable","1utdP-6fc0A:undetectable;1utdQ-6fc0A:undetectable"],["1UTD_S_TRPS81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.00A","1utdS-6fc0A:undetectable;1utdT-6fc0A:undetectable","1utdS-6fc0A:undetectable;1utdT-6fc0A:undetectable"],["1UTD_U_TRPU81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"ALA A 239;HIS A 233;THR A 234;GLY A 123;THR A 182","None","1.02A","1utdU-6fc0A:undetectable;1utdV-6fc0A:undetectable","1utdU-6fc0A:undetectable;1utdV-6fc0A:undetectable"],["1UTD_V_TRPV81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","1.00A","1utdL-6fc0A:undetectable;1utdV-6fc0A:undetectable","1utdL-6fc0A:undetectable;1utdV-6fc0A:undetectable"],["2QHF_A_ACTA509_0","CHORISMATE SYNTHASE","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4G","Chaetomium thermophilum",3,"ARG B 963;GLN B 954;PRO B 955","None","0.72A","2qhfA-6fc0B:undetectable","2qhfA-6fc0B:undetectable"],["3HRD_E_NIOE5660_1","NICOTINATE DEHYDROGENASE LARGE MOLYBDOPTERIN SUBUNIT;NICOTINATE DEHYDROGENASE LARGE MOLYBDOPTERIN SUBUNIT;NICOTINATE DEHYDROGENASE MEDIUM MOLYBDOPTERIN SUBUNIT","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",3,"GLU A 113;GLU A 115;TRP A 178","None","1.22A","3hrdA-6fc0A:undetectable;3hrdE-6fc0A:undetectable;3hrdF-6fc0A:undetectable","3hrdA-6fc0A:10.84;3hrdE-6fc0A:10.84;3hrdF-6fc0A:12.62"],["4UMJ_A_BFQA1298_1","GERANYLTRANSTRANSFERASE","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4G","Chaetomium thermophilum",4,"ILE B 980;PHE B1004;GLN B1003;ASP B1001","None","0.99A","4umjA-6fc0B:undetectable","4umjA-6fc0B:16.00"],["5EEV_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5eevA-6fc0A:undetectable;5eevB-6fc0A:0.6","5eevA-6fc0A:undetectable;5eevB-6fc0A:undetectable"],["5EEW_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5eewA-6fc0A:undetectable;5eewB-6fc0A:0.6","5eewA-6fc0A:undetectable;5eewB-6fc0A:undetectable"],["5EEX_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5eexA-6fc0A:undetectable;5eexB-6fc0A:undetectable","5eexA-6fc0A:undetectable;5eexB-6fc0A:undetectable"],["5EEY_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5eeyA-6fc0A:undetectable;5eeyB-6fc0A:0.6","5eeyA-6fc0A:undetectable;5eeyB-6fc0A:undetectable"],["5EEZ_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5eezA-6fc0A:undetectable;5eezB-6fc0A:undetectable","5eezA-6fc0A:undetectable;5eezB-6fc0A:undetectable"],["5EF0_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5ef0A-6fc0A:0.6;5ef0B-6fc0A:undetectable","5ef0A-6fc0A:undetectable;5ef0B-6fc0A:undetectable"],["5EF1_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5ef1A-6fc0A:undetectable;5ef1B-6fc0A:undetectable","5ef1A-6fc0A:undetectable;5ef1B-6fc0A:undetectable"],["5EF2_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5ef2A-6fc0A:undetectable;5ef2B-6fc0A:undetectable","5ef2A-6fc0A:undetectable;5ef2B-6fc0A:undetectable"],["5EF3_A_TRPA101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",5,"GLY A 123;THR A 182;ALA A 239;HIS A 233;THR A 234","None","0.99A","5ef3A-6fc0A:undetectable;5ef3B-6fc0A:0.5","5ef3A-6fc0A:undetectable;5ef3B-6fc0A:undetectable"],["5G08_A_Z80A1187_1","FREQUENIN 2","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN;EUKARYOTIC TRANSLATION INITIATION FACTOR 4G","Chaetomium thermophilum",4,"TYR B1000;PHE B 998;PHE B1008;THR A  35","None","1.30A","5g08A-6fc0B:undetectable","5g08A-6fc0B:13.98"],["5JMN_C_FUAC1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",3,"VAL A 164;HIS A 143;VAL A 219","None","0.37A","5jmnC-6fc0A:3.0","5jmnC-6fc0A:6.61"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN;EUKARYOTIC TRANSLATION INITIATION FACTOR 4G","Chaetomium thermophilum;Chaetomium thermophilum",4,"PHE B1004;ASN B 984;LEU B 987;GLY A 150","None","1.05A","5o4yA-6fc0B:undetectable","5o4yA-6fc0B:undetectable"],["5TJY_A_BEZA304_0","4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",3,"MET A 162;GLU A 203;ARG A 180","None","1.08A","5tjyA-6fc0A:undetectable","5tjyA-6fc0A:undetectable"],["5TJZ_A_BEZA302_0","4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE","6fc0","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-LIKE PROTEIN","Chaetomium thermophilum",3,"MET A 162;GLU A 203;ARG A 180","None","1.05A","5tjzA-6fc0A:undetectable","5tjzA-6fc0A:undetectable"]]