SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 6fc3 CAP-ASSOCIATED
PROTEIN CAF20
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 11 LEU B   9
LEU B  12
GLU A  72
LEU A  39
LEU A 131
 None
 1.31A 3hm1B-6fc3B:
undetectable		 3hm1B-6fc3B:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 6fc3 CAP-ASSOCIATED
PROTEIN CAF20
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 10 LEU B   9
LEU B  12
GLU A  72
LEU A  39
LEU A 131
 None
 1.44A 3ollA-6fc3B:
undetectable		 3ollA-6fc3B:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 152
VAL A 137
ILE A 142
LEU A 186
 None
 0.93A 4l1wB-6fc3A:
undetectable		 4l1wB-6fc3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 185
LEU A 186
LEU A 165
PHE A  68
 None
 0.80A 4o1zA-6fc3A:
undetectable		 4o1zA-6fc3A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 185
LEU A 186
VAL A 152
LEU A 165
PHE A  68
 None
 0.88A 4o1zB-6fc3A:
undetectable		 4o1zB-6fc3A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 171
GLU A 170
PRO A 198
ILE A 211
THR A 167
 None
 0.92A 4urnA-6fc3A:
undetectable		 4urnA-6fc3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fc3 CAP-ASSOCIATED
PROTEIN CAF20
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 9 PHE B  22
ILE A  77
PHE B  27
LEU A  87
LEU A 154
 None
 1.34A 4ze0A-6fc3B:
undetectable		 4ze0A-6fc3B:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 161
ILE A  81
TYR A  47
PHE A  96
 None
 1.31A 5igvA-6fc3A:
undetectable		 5igvA-6fc3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 185
GLY A 179
LEU A 134
ILE A 149
ALA A 136
 None
 1.06A 5vm8B-6fc3A:
undetectable		 5vm8B-6fc3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 198
SER A 200
SER A 201
 None
 0.29A 6bpyA-6fc3A:
undetectable		 6bpyA-6fc3A:
undetectable