SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I00_B_D16B409_1 (THYMIDYLATE SYNTHASE)	6fc5	MICROTUBULE-ASSOCIAT ED PROTEIN (Saccharomyces cerevisiae)	5 / 9	ILE A 68 ASP A 39 LEU A 40 GLY A 65 ASN A 47	None	1.22A	1i00B-6fc5A: undetectable	1i00B-6fc5A: 15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_C_D16C402_1 (THYMIDYLATE SYNTHASE)	6fc5	MICROTUBULE-ASSOCIAT ED PROTEIN (Saccharomyces cerevisiae)	5 / 9	ILE A 68 ASP A 39 LEU A 40 GLY A 65 ASN A 47	None	1.20A	4eb4C-6fc5A: undetectable	4eb4C-6fc5A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_D_D16D402_1 (THYMIDYLATE SYNTHASE)	6fc5	MICROTUBULE-ASSOCIAT ED PROTEIN (Saccharomyces cerevisiae)	5 / 10	ILE A 68 ASP A 39 LEU A 40 GLY A 65 ASN A 47	None	1.20A	4eb4D-6fc5A: undetectable	4eb4D-6fc5A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_B_SORB1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	6fc5	MICROTUBULE-ASSOCIAT ED PROTEIN (Saccharomyces cerevisiae)	4 / 7	ILE A 8 CYH A 10 LEU A 22 GLY A 37	None	0.74A	5a06B-6fc5A: undetectable	5a06B-6fc5A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I00_B_D16B409_1","THYMIDYLATE SYNTHASE","6fc5","MICROTUBULE-ASSOCIATED PROTEIN","Saccharomyces cerevisiae",5,"ILE A  68;ASP A  39;LEU A  40;GLY A  65;ASN A  47","None","1.22A","1i00B-6fc5A:undetectable","1i00B-6fc5A:15.58"],["4EB4_C_D16C402_1","THYMIDYLATE SYNTHASE","6fc5","MICROTUBULE-ASSOCIATED PROTEIN","Saccharomyces cerevisiae",5,"ILE A  68;ASP A  39;LEU A  40;GLY A  65;ASN A  47","None","1.20A","4eb4C-6fc5A:undetectable","4eb4C-6fc5A:16.67"],["4EB4_D_D16D402_1","THYMIDYLATE SYNTHASE","6fc5","MICROTUBULE-ASSOCIATED PROTEIN","Saccharomyces cerevisiae",5,"ILE A  68;ASP A  39;LEU A  40;GLY A  65;ASN A  47","None","1.20A","4eb4D-6fc5A:undetectable","4eb4D-6fc5A:16.67"],["5A06_B_SORB1342_0","ALDOSE-ALDOSE OXIDOREDUCTASE","6fc5","MICROTUBULE-ASSOCIATED PROTEIN","Saccharomyces cerevisiae",4,"ILE A   8;CYH A  10;LEU A  22;GLY A  37","None","0.74A","5a06B-6fc5A:undetectable","5a06B-6fc5A:undetectable"]]