SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_A_STRA1_1 (PROGESTERONE RECEPTOR)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	LEU A 621 ASN A 620 LEU A 513 LEU A 526 PHE A 580	None	1.33A	1a28A-6fcxA: undetectable	1a28A-6fcxA: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_A_STRA1_1 (PROGESTERONE RECEPTOR)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	LEU A 621 ASN A 620 LEU A 513 LEU A 526 THR A 549	None	1.27A	1a28A-6fcxA: undetectable	1a28A-6fcxA: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_B_STRB2_1 (PROGESTERONE RECEPTOR)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	LEU A 621 ASN A 620 LEU A 513 LEU A 526 THR A 549	None	1.32A	1a28B-6fcxA: undetectable	1a28B-6fcxA: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK3_A_T44A3003_1 (SERUM ALBUMIN)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	3 / 4	LYS A 144 ALA A 145 MET A 110	None	1.06A	1hk3A-6fcxA: undetectable	1hk3A-6fcxA: 9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_C_THAC3_1 (LIVER CARBOXYLESTERASE I)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	THR A 329 VAL A 332 LEU A 333 LEU A 310 LEU A 336	None	1.01A	1mx1C-6fcxA: undetectable	1mx1C-6fcxA: 11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_I_BEZI518_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 7	ILE A 259 GLY A 261 PRO A 258 ASN A 296 ARG A 325	None None None None CIT A 703 (-3.6A)	1.32A	1oniG-6fcxA: undetectable 1oniI-6fcxA: undetectable	1oniG-6fcxA: undetectable 1oniI-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FT9_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN 2, LIVER)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	PHE A 207 ILE A 225 ILE A 252 CYH A 250 LEU A 211	None	1.28A	2ft9A-6fcxA: undetectable	2ft9A-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_A_SNLA1001_1 (MINERALOCORTICOID RECEPTOR)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 12	LEU A 62 LEU A 89 ARG A 41 THR A 329 PHE A 320	None	1.45A	2oaxA-6fcxA: undetectable	2oaxA-6fcxA: 15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_A_BEZA1222_0 (PEROXIREDOXIN 6)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 577 VAL A 578 SER A 579 PRO A 556	None	0.99A	2v2gA-6fcxA: undetectable 2v2gB-6fcxA: undetectable	2v2gA-6fcxA: undetectable 2v2gB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_B_BEZB1220_0 (PEROXIREDOXIN 6)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 556 PRO A 577 VAL A 578 SER A 579	None	0.99A	2v2gA-6fcxA: undetectable 2v2gB-6fcxA: undetectable	2v2gA-6fcxA: undetectable 2v2gB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_C_BEZC1222_0 (PEROXIREDOXIN 6)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 577 VAL A 578 SER A 579 PRO A 556	None	1.06A	2v2gC-6fcxA: undetectable 2v2gD-6fcxA: undetectable	2v2gC-6fcxA: undetectable 2v2gD-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_D_BEZD1221_0 (PEROXIREDOXIN 6)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 556 PRO A 577 VAL A 578 SER A 579	None	0.95A	2v2gC-6fcxA: undetectable 2v2gD-6fcxA: undetectable	2v2gC-6fcxA: undetectable 2v2gD-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_C_BEZC1218_0 (PEROXIREDOXIN 6.)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 8	PRO A 577 VAL A 578 SER A 579 PRO A 556	None	0.94A	2v41C-6fcxA: undetectable 2v41D-6fcxA: undetectable	2v41C-6fcxA: undetectable 2v41D-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_F_BEZF1222_0 (PEROXIREDOXIN 6.)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 556 PRO A 577 VAL A 578 SER A 579	None	0.89A	2v41E-6fcxA: undetectable 2v41F-6fcxA: undetectable	2v41E-6fcxA: undetectable 2v41F-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_H_BEZH1222_0 (PEROXIREDOXIN 6.)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 8	PRO A 556 PRO A 577 VAL A 578 SER A 579	None	0.92A	2v41G-6fcxA: undetectable 2v41H-6fcxA: undetectable	2v41G-6fcxA: undetectable 2v41H-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YFB_A_ACTA501_0 (METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	ASP A 223 VAL A 179 ARG A 183 ILE A 182	None	1.12A	2yfbA-6fcxA: undetectable	2yfbA-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YFB_B_ACTB501_0 (METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 6	ASP A 223 VAL A 179 ARG A 183 ILE A 182	None	1.10A	2yfbB-6fcxA: undetectable	2yfbB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APT_B_ACTB311_0 (METHYLENETETRAHYDROF OLATE REDUCTASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	6 / 9	GLU A 63 HIS A 127 ALA A 195 ILE A 226 HIS A 319 TYR A 321	FAD A 701 ( 4.5A) FAD A 701 (-4.0A) FAD A 701 (-3.4A) FAD A 701 ( 4.2A) None None	0.56A	3aptB-6fcxA: 32.5	3aptB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_A_PM6A302_1 (THIOPURINE S-METHYLTRANSFERASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 6	THR A 235 PHE A 237 LEU A 305 LEU A 309	None	1.17A	3bgdA-6fcxA: undetectable	3bgdA-6fcxA: 15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP2_B_PNNB5002_0 (TRANSCRIPTIONAL REGULATOR TCAR)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 5	ASN A 290 ALA A 293 ALA A 292 ARG A 295	None None None CIT A 703 (-3.1A)	1.16A	3kp2B-6fcxA: undetectable	3kp2B-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_A_RITA600_2 (CYTOCHROME P450 3A4)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PHE A 64 ARG A 295 ILE A 299 LEU A 333	None CIT A 703 (-3.1A) None None	1.17A	3nxuA-6fcxA: undetectable	3nxuA-6fcxA: 9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UZZ_B_ASDB501_1 (3-OXO-5-BETA-STEROID 4-DEHYDROGENASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 8	TYR A 321 TYR A 90 MET A 49 TRP A 59	None	1.42A	3uzzB-6fcxA: 9.0	3uzzB-6fcxA: 13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A3U_B_ACTB1358_0 (NADH:FLAVIN OXIDOREDUCTASE/NADH OXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PRO A 502 GLY A 562 VAL A 507 SER A 493	None	0.81A	4a3uB-6fcxA: 8.5	4a3uB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_E_377E401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 6	ASN A 624 GLU A 533 TYR A 538 LEU A 621	None	1.00A	4twdD-6fcxA: undetectable 4twdE-6fcxA: undetectable	4twdD-6fcxA: 12.97 4twdE-6fcxA: 12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_J_377J401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 6	ASN A 624 GLU A 533 TYR A 538 LEU A 621	None	1.04A	4twdI-6fcxA: undetectable 4twdJ-6fcxA: undetectable	4twdI-6fcxA: 12.97 4twdJ-6fcxA: 12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UYM_B_VORB590_1 (14-ALPHA STEROL DEMETHYLASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	PHE A 207 ALA A 242 ILE A 252 LEU A 214	None	0.97A	4uymB-6fcxA: undetectable	4uymB-6fcxA: 10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E4D_B_BEZB202_0 (HYDROXYNITRILE LYASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 7	VAL A 636 THR A 639 LEU A 513 VAL A 619	None	1.02A	5e4dA-6fcxA: undetectable 5e4dB-6fcxA: undetectable	5e4dA-6fcxA: undetectable 5e4dB-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ICX_E_SC2E1_1 (CETUXIMAB FAB LIGHT CHAIN MEDITOPE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	3 / 3	VAL A 536 GLN A 634 CYH A 631	None	0.81A	5icxA-6fcxA: 1.9 5icxE-6fcxA: undetectable	5icxA-6fcxA: 16.90 5icxE-6fcxA: 11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA615_1 (PHIAB6 TAILSPIKE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	3 / 3	TYR A 321 TYR A 197 GLN A 228	None FAD A 701 (-4.4A) FAD A 701 ( 4.5A)	0.99A	5jsdA-6fcxA: 1.5 5jsdB-6fcxA: undetectable	5jsdA-6fcxA: 7.39 5jsdB-6fcxA: 7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB606_1 (PHIAB6 TAILSPIKE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	3 / 3	TYR A 321 TYR A 197 GLN A 228	None FAD A 701 (-4.4A) FAD A 701 ( 4.5A)	0.98A	5jsdB-6fcxA: undetectable 5jsdC-6fcxA: undetectable	5jsdB-6fcxA: 7.39 5jsdC-6fcxA: 7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KSG_B_NIZB809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.30A	5ksgB-6fcxA: undetectable	5ksgB-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KSN_A_NIZA809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.31A	5ksnA-6fcxA: undetectable	5ksnA-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KSN_B_NIZB809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.29A	5ksnB-6fcxA: undetectable	5ksnB-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KT8_B_NIZB809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.30A	5kt8B-6fcxA: undetectable	5kt8B-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXS_B_NIZB806_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.29A	5sxsB-6fcxA: undetectable	5sxsB-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYI_B_NIZB805_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.30A	5syiB-6fcxA: undetectable	5syiB-6fcxA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_C_CHDC401_0 (BILE SALT HYDROLASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	4 / 8	LEU A 271 TYR A 321 ALA A 195 LEU A 156	None None FAD A 701 (-3.4A) FAD A 701 (-3.9A)	0.73A	5y7pC-6fcxA: undetectable	5y7pC-6fcxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDQ_A_NIZA809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.30A	6cdqA-6fcxA: undetectable	6cdqA-6fcxA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDQ_B_NIZB808_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.28A	6cdqB-6fcxA: undetectable	6cdqB-6fcxA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CFQ_B_NIZB809_1 (CATALASE-PEROXIDASE)	6fcx	METHYLENETETRAHYDROF OLATE REDUCTASE (Homo sapiens)	5 / 9	GLU A 63 GLY A 255 GLN A 228 LEU A 229 THR A 227	FAD A 701 ( 4.5A) None FAD A 701 ( 4.5A) None None	1.29A	6cfqB-6fcxA: undetectable	6cfqB-6fcxA: 13.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A28_A_STRA1_1","PROGESTERONE RECEPTOR","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"LEU A 621;ASN A 620;LEU A 513;LEU A 526;PHE A 580","None","1.33A","1a28A-6fcxA:undetectable","1a28A-6fcxA:14.72"],["1A28_A_STRA1_1","PROGESTERONE RECEPTOR","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"LEU A 621;ASN A 620;LEU A 513;LEU A 526;THR A 549","None","1.27A","1a28A-6fcxA:undetectable","1a28A-6fcxA:14.72"],["1A28_B_STRB2_1","PROGESTERONE RECEPTOR","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"LEU A 621;ASN A 620;LEU A 513;LEU A 526;THR A 549","None","1.32A","1a28B-6fcxA:undetectable","1a28B-6fcxA:14.72"],["1HK3_A_T44A3003_1","SERUM ALBUMIN","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",3,"LYS A 144;ALA A 145;MET A 110","None","1.06A","1hk3A-6fcxA:undetectable","1hk3A-6fcxA:9.90"],["1MX1_C_THAC3_1","LIVER CARBOXYLESTERASE I","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"THR A 329;VAL A 332;LEU A 333;LEU A 310;LEU A 336","None","1.01A","1mx1C-6fcxA:undetectable","1mx1C-6fcxA:11.14"],["1ONI_I_BEZI518_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"ILE A 259;GLY A 261;PRO A 258;ASN A 296;ARG A 325","None;None;None;None;CIT A 703 (-3.6A)","1.32A","1oniG-6fcxA:undetectable;1oniI-6fcxA:undetectable","1oniG-6fcxA:undetectable;1oniI-6fcxA:undetectable"],["2FT9_A_CHDA130_0","FATTY ACID-BINDING PROTEIN 2, LIVER","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"PHE A 207;ILE A 225;ILE A 252;CYH A 250;LEU A 211","None","1.28A","2ft9A-6fcxA:undetectable","2ft9A-6fcxA:undetectable"],["2OAX_A_SNLA1001_1","MINERALOCORTICOID RECEPTOR","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"LEU A  62;LEU A  89;ARG A  41;THR A 329;PHE A 320","None","1.45A","2oaxA-6fcxA:undetectable","2oaxA-6fcxA:15.19"],["2V2G_A_BEZA1222_0","PEROXIREDOXIN 6","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 577;VAL A 578;SER A 579;PRO A 556","None","0.99A","2v2gA-6fcxA:undetectable;2v2gB-6fcxA:undetectable","2v2gA-6fcxA:undetectable;2v2gB-6fcxA:undetectable"],["2V2G_B_BEZB1220_0","PEROXIREDOXIN 6","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 556;PRO A 577;VAL A 578;SER A 579","None","0.99A","2v2gA-6fcxA:undetectable;2v2gB-6fcxA:undetectable","2v2gA-6fcxA:undetectable;2v2gB-6fcxA:undetectable"],["2V2G_C_BEZC1222_0","PEROXIREDOXIN 6","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 577;VAL A 578;SER A 579;PRO A 556","None","1.06A","2v2gC-6fcxA:undetectable;2v2gD-6fcxA:undetectable","2v2gC-6fcxA:undetectable;2v2gD-6fcxA:undetectable"],["2V2G_D_BEZD1221_0","PEROXIREDOXIN 6","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 556;PRO A 577;VAL A 578;SER A 579","None","0.95A","2v2gC-6fcxA:undetectable;2v2gD-6fcxA:undetectable","2v2gC-6fcxA:undetectable;2v2gD-6fcxA:undetectable"],["2V41_C_BEZC1218_0","PEROXIREDOXIN 6.","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 577;VAL A 578;SER A 579;PRO A 556","None","0.94A","2v41C-6fcxA:undetectable;2v41D-6fcxA:undetectable","2v41C-6fcxA:undetectable;2v41D-6fcxA:undetectable"],["2V41_F_BEZF1222_0","PEROXIREDOXIN 6.","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 556;PRO A 577;VAL A 578;SER A 579","None","0.89A","2v41E-6fcxA:undetectable;2v41F-6fcxA:undetectable","2v41E-6fcxA:undetectable;2v41F-6fcxA:undetectable"],["2V41_H_BEZH1222_0","PEROXIREDOXIN 6.","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 556;PRO A 577;VAL A 578;SER A 579","None","0.92A","2v41G-6fcxA:undetectable;2v41H-6fcxA:undetectable","2v41G-6fcxA:undetectable;2v41H-6fcxA:undetectable"],["2YFB_A_ACTA501_0","METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"ASP A 223;VAL A 179;ARG A 183;ILE A 182","None","1.12A","2yfbA-6fcxA:undetectable","2yfbA-6fcxA:undetectable"],["2YFB_B_ACTB501_0","METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"ASP A 223;VAL A 179;ARG A 183;ILE A 182","None","1.10A","2yfbB-6fcxA:undetectable","2yfbB-6fcxA:undetectable"],["3APT_B_ACTB311_0","METHYLENETETRAHYDROFOLATE REDUCTASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",6,"GLU A  63;HIS A 127;ALA A 195;ILE A 226;HIS A 319;TYR A 321","FAD A 701 ( 4.5A);FAD A 701 (-4.0A);FAD A 701 (-3.4A);FAD A 701 ( 4.2A);None;None","0.56A","3aptB-6fcxA:32.5","3aptB-6fcxA:undetectable"],["3BGD_A_PM6A302_1","THIOPURINE S-METHYLTRANSFERASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"THR A 235;PHE A 237;LEU A 305;LEU A 309","None","1.17A","3bgdA-6fcxA:undetectable","3bgdA-6fcxA:15.71"],["3KP2_B_PNNB5002_0","TRANSCRIPTIONAL REGULATOR TCAR","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"ASN A 290;ALA A 293;ALA A 292;ARG A 295","None;None;None;CIT A 703 (-3.1A)","1.16A","3kp2B-6fcxA:undetectable","3kp2B-6fcxA:undetectable"],["3NXU_A_RITA600_2","CYTOCHROME P450 3A4","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PHE A  64;ARG A 295;ILE A 299;LEU A 333","None;CIT A 703 (-3.1A);None;None","1.17A","3nxuA-6fcxA:undetectable","3nxuA-6fcxA:9.30"],["3UZZ_B_ASDB501_1","3-OXO-5-BETA-STEROID 4-DEHYDROGENASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"TYR A 321;TYR A  90;MET A  49;TRP A  59","None","1.42A","3uzzB-6fcxA:9.0","3uzzB-6fcxA:13.08"],["4A3U_B_ACTB1358_0","NADH:FLAVIN OXIDOREDUCTASE\/NADH OXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PRO A 502;GLY A 562;VAL A 507;SER A 493","None","0.81A","4a3uB-6fcxA:8.5","4a3uB-6fcxA:undetectable"],["4TWD_E_377E401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"ASN A 624;GLU A 533;TYR A 538;LEU A 621","None","1.00A","4twdD-6fcxA:undetectable;4twdE-6fcxA:undetectable","4twdD-6fcxA:12.97;4twdE-6fcxA:12.97"],["4TWD_J_377J401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"ASN A 624;GLU A 533;TYR A 538;LEU A 621","None","1.04A","4twdI-6fcxA:undetectable;4twdJ-6fcxA:undetectable","4twdI-6fcxA:12.97;4twdJ-6fcxA:12.97"],["4UYM_B_VORB590_1","14-ALPHA STEROL DEMETHYLASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"PHE A 207;ALA A 242;ILE A 252;LEU A 214","None","0.97A","4uymB-6fcxA:undetectable","4uymB-6fcxA:10.96"],["5E4D_B_BEZB202_0","HYDROXYNITRILE LYASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"VAL A 636;THR A 639;LEU A 513;VAL A 619","None","1.02A","5e4dA-6fcxA:undetectable;5e4dB-6fcxA:undetectable","5e4dA-6fcxA:undetectable;5e4dB-6fcxA:undetectable"],["5ICX_E_SC2E1_1","CETUXIMAB FAB LIGHT CHAIN;MEDITOPE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",3,"VAL A 536;GLN A 634;CYH A 631","None","0.81A","5icxA-6fcxA:1.9;5icxE-6fcxA:undetectable","5icxA-6fcxA:16.90;5icxE-6fcxA:11.59"],["5JSD_A_1GNA615_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",3,"TYR A 321;TYR A 197;GLN A 228","None;FAD A 701 (-4.4A);FAD A 701 ( 4.5A)","0.99A","5jsdA-6fcxA:1.5;5jsdB-6fcxA:undetectable","5jsdA-6fcxA:7.39;5jsdB-6fcxA:7.39"],["5JSD_B_1GNB606_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",3,"TYR A 321;TYR A 197;GLN A 228","None;FAD A 701 (-4.4A);FAD A 701 ( 4.5A)","0.98A","5jsdB-6fcxA:undetectable;5jsdC-6fcxA:undetectable","5jsdB-6fcxA:7.39;5jsdC-6fcxA:7.39"],["5KSG_B_NIZB809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.30A","5ksgB-6fcxA:undetectable","5ksgB-6fcxA:8.52"],["5KSN_A_NIZA809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.31A","5ksnA-6fcxA:undetectable","5ksnA-6fcxA:8.52"],["5KSN_B_NIZB809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.29A","5ksnB-6fcxA:undetectable","5ksnB-6fcxA:8.52"],["5KT8_B_NIZB809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.30A","5kt8B-6fcxA:undetectable","5kt8B-6fcxA:8.52"],["5SXS_B_NIZB806_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.29A","5sxsB-6fcxA:undetectable","5sxsB-6fcxA:8.52"],["5SYI_B_NIZB805_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.30A","5syiB-6fcxA:undetectable","5syiB-6fcxA:8.52"],["5Y7P_C_CHDC401_0","BILE SALT HYDROLASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",4,"LEU A 271;TYR A 321;ALA A 195;LEU A 156","None;None;FAD A 701 (-3.4A);FAD A 701 (-3.9A)","0.73A","5y7pC-6fcxA:undetectable","5y7pC-6fcxA:undetectable"],["6CDQ_A_NIZA809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.30A","6cdqA-6fcxA:undetectable","6cdqA-6fcxA:13.58"],["6CDQ_B_NIZB808_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.28A","6cdqB-6fcxA:undetectable","6cdqB-6fcxA:13.58"],["6CFQ_B_NIZB809_1","CATALASE-PEROXIDASE","6fcx","METHYLENETETRAHYDROFOLATE REDUCTASE","Homo sapiens",5,"GLU A  63;GLY A 255;GLN A 228;LEU A 229;THR A 227","FAD A 701 ( 4.5A);None;FAD A 701 ( 4.5A);None;None","1.29A","6cfqB-6fcxA:undetectable","6cfqB-6fcxA:13.58"]]