SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 TYR B 216
THR B  32
SER B 406
TYR B  26
D5E  B 501 ( 4.5A)
D5E  B 501 (-3.4A)
D5E  B 501 ( 3.4A)
D5E  B 501 (-3.7A)
1.08A 1eiiA-6fd2B:
undetectable
1eiiA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 LEU B  96
ASP B  92
LEU B  89
ARG B  24
None
1.07A 1mt1A-6fd2B:
undetectable
1mt1F-6fd2B:
undetectable
1mt1A-6fd2B:
18.18
1mt1F-6fd2B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 ARG B  24
LEU B  96
ASP B  92
LEU B  89
None
1.04A 1mt1B-6fd2B:
undetectable
1mt1C-6fd2B:
undetectable
1mt1B-6fd2B:
21.55
1mt1C-6fd2B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 LEU B  96
ASP B  92
LEU B  89
ARG B  24
None
1.05A 1n13I-6fd2B:
undetectable
1n13L-6fd2B:
undetectable
1n13I-6fd2B:
18.18
1n13L-6fd2B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 8 TYR B  26
GLU B 303
VAL B 342
GLU B  37
D5E  B 501 (-3.7A)
D5E  B 501 (-3.1A)
None
D5E  B 501 (-3.0A)
1.22A 1s3zA-6fd2B:
undetectable
1s3zB-6fd2B:
undetectable
1s3zA-6fd2B:
undetectable
1s3zB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 10 SER B 425
VAL B 378
HIS B 407
THR B 405
ASP B 429
None
None
D5E  B 501 ( 4.8A)
None
None
1.44A 1td2A-6fd2B:
3.3
1td2A-6fd2B:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 5 GLY B 221
PRO B 252
VAL B 253
ILE B 224
None
None
MET  B 503 ( 4.9A)
None
1.00A 2aoiA-6fd2B:
undetectable
2aoiA-6fd2B:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 11 SER B 308
ILE B 357
SER B 356
ALA B 424
ILE B 379
None
None
None
None
5AD  B 504 ( 4.8A)
1.03A 2nnhA-6fd2B:
undetectable
2nnhA-6fd2B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 5 THR B  79
ARG B 105
ALA B 104
ARG B 100
None
1.08A 2qhfA-6fd2B:
undetectable
2qhfA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 ARG B  24
LEU B  96
ASP B  92
LEU B  89
None
1.01A 2qqcB-6fd2B:
undetectable
2qqcC-6fd2B:
undetectable
2qqcB-6fd2B:
22.41
2qqcC-6fd2B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 LEU B  96
ASP B  92
LEU B  89
ARG B  24
None
1.03A 2qqcA-6fd2B:
undetectable
2qqcF-6fd2B:
undetectable
2qqcA-6fd2B:
15.58
2qqcF-6fd2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 LEU B  96
ASP B  92
LEU B  89
ARG B  24
None
1.02A 2qqcG-6fd2B:
undetectable
2qqcJ-6fd2B:
undetectable
2qqcG-6fd2B:
15.58
2qqcJ-6fd2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 LEU B  96
ASP B  92
LEU B  89
ARG B  24
None
1.02A 2qqcI-6fd2B:
undetectable
2qqcL-6fd2B:
undetectable
2qqcI-6fd2B:
15.58
2qqcL-6fd2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_B_TC9B1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 11 TYR B 382
TYR B 216
GLN B  23
SER B  85
SER B 111
5AD  B 504 (-4.8A)
D5E  B 501 ( 4.5A)
None
None
None
1.30A 2xytB-6fd2B:
0.0
2xytC-6fd2B:
0.0
2xytG-6fd2B:
0.0
2xytB-6fd2B:
17.86
2xytC-6fd2B:
17.86
2xytG-6fd2B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 8 ILE B 357
ALA B 424
ARG B 426
LEU B 376
None
0.94A 3hrdA-6fd2B:
undetectable
3hrdB-6fd2B:
undetectable
3hrdA-6fd2B:
10.35
3hrdB-6fd2B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 LEU B 132
GLU B 134
PRO B 150
ARG B 113
None
1.49A 3ltwA-6fd2B:
undetectable
3ltwA-6fd2B:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 8 GLU B 174
ARG B 231
ARG B  48
PHE B 204
None
1.08A 3mjrD-6fd2B:
undetectable
3mjrD-6fd2B:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 GLY B  28
GLY B  29
SER B 219
LEU B  86
None
0.83A 3o9mB-6fd2B:
3.3
3o9mB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 7 GLN B 446
HIS B 450
ARG B 358
PRO B 311
None
1.36A 3ql6A-6fd2B:
undetectable
3ql6A-6fd2B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 9 LEU B 152
ALA B 108
GLY B 126
PRO B 155
THR B 154
None
1.21A 3spkA-6fd2B:
undetectable
3spkA-6fd2B:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 4 LEU B 369
GLY B 368
LEU B 365
GLU B 366
None
0.98A 3tgvB-6fd2B:
undetectable
3tgvB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 ASP B  58
ARG B   5
LYS B   5
None
1.04A 3wipG-6fd2B:
undetectable
3wipG-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 5 GLU B 235
SER B 199
ARG B 231
PRO B 177
None
1.36A 4k17B-6fd2B:
2.5
4k17B-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 ARG B 260
LEU B 264
GLU B 263
None
0.62A 4l3gF-6fd2B:
undetectable
4l3gF-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 12 PRO B 115
ALA B 108
ALA B  93
GLY B 125
LEU B  96
None
0.97A 4oaeA-6fd2B:
undetectable
4oaeA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 GLN B 446
HIS B 450
ARG B 358
None
1.24A 4qyqA-6fd2B:
undetectable
4qyqA-6fd2B:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 GLN B 446
HIS B 450
ARG B 358
None
1.23A 4qyqB-6fd2B:
undetectable
4qyqB-6fd2B:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 ARG B 319
GLU B 352
TYR B 213
None
None
5AD  B 504 (-4.5A)
0.73A 4r29D-6fd2B:
undetectable
4r29D-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 TYR B 227
ASN B 201
GLU B 174
PHE B 168
None
1.49A 4twdG-6fd2B:
undetectable
4twdH-6fd2B:
undetectable
4twdG-6fd2B:
15.02
4twdH-6fd2B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 GLY B  29
TYR B 216
ALA B  27
ARG B 250
None
D5E  B 501 ( 4.5A)
D5E  B 501 (-4.0A)
D5E  B 501 (-4.5A)
1.22A 4yshB-6fd2B:
undetectable
4yshB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
3 / 3 ALA B 108
TYR B 107
PRO B 155
None
0.70A 4zdyA-6fd2B:
undetectable
4zdyA-6fd2B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 12 GLY B 384
LEU B 158
PHE B 122
GLY B 129
LEU B 132
None
1.14A 4ze1A-6fd2B:
undetectable
4ze1A-6fd2B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 6 ILE B 200
HIS B  83
ILE B  62
VAL B 182
None
0.85A 4zj8A-6fd2B:
undetectable
4zj8A-6fd2B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
4 / 5 LEU B  46
ALA B  63
LEU B  11
VAL B  70
None
1.07A 5cr1A-6fd2B:
undetectable
5cr1A-6fd2B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteich
us
tenebrarius)
5 / 12 VAL B 342
GLU B 373
LEU B 322
ARG B 335
LEU B 367
None
1.30A 5nd2B-6fd2B:
undetectable
5nd2B-6fd2B:
11.24