SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 126
PRO A  79
ALA A 131
SER A  98
 None
 0.96A 1lqtA-6fdfA:
4.6		 1lqtA-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A 126
PRO A  79
ALA A 131
SER A  98
 None
 0.95A 1lquA-6fdfA:
4.8		 1lquA-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A  15
HIS A  50
TYR A  21
PRO A 289
 SAH  A 401 (-3.4A)
None
None
None
 0.99A 1th6A-6fdfA:
undetectable		 1th6A-6fdfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A  15
HIS A  50
TYR A  21
PRO A 289
 SAH  A 401 (-3.4A)
None
None
None
 0.98A 2armA-6fdfA:
undetectable		 2armA-6fdfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
GLY A  18
MET A  19
ASP A  58
ILE A  59
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 0.86A 2b25A-6fdfA:
8.4		 2b25A-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
GLY A  18
MET A  19
ASP A  58
ILE A  59
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 0.85A 2b25B-6fdfA:
7.3		 2b25B-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  37
ILE A  38
ASN A  39
ALA A  42
ASP A  58
 SAH  A 401 (-2.7A)
SAH  A 401 ( 4.0A)
None
SAH  A 401 ( 4.5A)
SAH  A 401 (-3.8A)
 0.45A 3ay0A-6fdfA:
8.1		 3ay0A-6fdfA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A  15
ASP A  37
ILE A  38
ASN A  39
ASP A  58
 SAH  A 401 (-3.4A)
SAH  A 401 (-2.7A)
SAH  A 401 ( 4.0A)
None
SAH  A 401 (-3.8A)
 0.40A 3ay0B-6fdfA:
8.3		 3ay0B-6fdfA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 319
LEU A 320
GLY A  18
ILE A 158
 None
None
SAH  A 401 (-3.6A)
None
 0.79A 3jusA-6fdfA:
undetectable		 3jusA-6fdfA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 319
LEU A 320
GLY A  18
ILE A 158
 None
None
SAH  A 401 (-3.6A)
None
 0.79A 3jusA-6fdfA:
undetectable		 3jusA-6fdfA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY A  15
ASP A  37
ASP A  58
 SAH  A 401 (-3.4A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.8A)
 0.36A 3ou7C-6fdfA:
7.8		 3ou7C-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 211
TYR A 305
GLU A 203
 None
 0.92A 3pfgA-6fdfA:
9.3		 3pfgA-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 5 SER A 311
ASP A  37
ASP A  58
ILE A  59
 SAH  A 401 (-2.8A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 1.04A 3uj7B-6fdfA:
8.3		 3uj7B-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
ASP A  37
ILE A  38
ASP A  58
ILE A  59
 SAH  A 401 (-3.4A)
SAH  A 401 (-2.7A)
SAH  A 401 ( 4.0A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 0.46A 4iv8A-6fdfA:
8.6		 4iv8A-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
ASP A  37
ILE A  38
ASP A  58
ILE A  59
 SAH  A 401 (-3.4A)
SAH  A 401 (-2.7A)
SAH  A 401 ( 4.0A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 0.46A 4iv8B-6fdfA:
8.6		 4iv8B-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A  17
SER A 311
GLU A  11
ASN A  24
 SAH  A 401 ( 4.7A)
SAH  A 401 (-2.8A)
None
None
 1.07A 5n5dB-6fdfA:
8.7		 5n5dB-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 6 TRP A 294
LEU A 285
TYR A 211
GLU A 203
 None
 1.27A 6djzC-6fdfA:
undetectable		 6djzC-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
GLY A  18
ASP A  58
ASN A 310
SER A 311
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
None
SAH  A 401 (-2.8A)
 0.44A 6mhtA-6fdfA:
26.9		 6mhtA-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A  15
GLY A  18
ASP A  58
ILE A  59
ASN A 310
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
None
 0.73A 6mhtA-6fdfA:
26.9		 6mhtA-6fdfA:
undetectable