SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 ASP A 384
GLY A 385
ILE A  34
ILE A  12
ALA A  38
 None
 1.01A 1sguB-6feaA:
undetectable		 1sguB-6feaA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 ASP A 384
GLY A 385
ILE A  34
ILE A  12
ALA A  38
 None
 1.06A 1sh9B-6feaA:
undetectable		 1sh9B-6feaA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ARG A 441
GLY A 428
PRO A 429
 None
 0.75A 2hreD-6feaA:
undetectable		 2hreD-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		3 / 3 ARG C 102
ARG A  29
ARG C  94
 None
 1.18A 2jb7A-6feaC:
undetectable
2jb7B-6feaC:
undetectable
2jb7C-6feaC:
undetectable		 2jb7A-6feaC:
undetectable
2jb7B-6feaC:
undetectable
2jb7C-6feaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		6 / 12 GLY A  59
GLY A 237
GLY A 239
THR A 217
LEU A 220
LYS A  83
 None
None
None
None
None
D6N  A 502 (-3.1A)
 1.41A 2oxtB-6feaA:
2.1		 2oxtB-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 TRP A 282
GLN A 214
TRP A 224
 None
 1.09A 2vqyA-6feaA:
undetectable		 2vqyA-6feaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PHE A 403
TYR A 425
ILE A 213
TYR A 430
GLY A 215
 None
 1.49A 2vufA-6feaA:
undetectable		 2vufA-6feaA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PHE A 403
TYR A 425
ILE A 213
TYR A 430
GLY A 215
 None
 1.45A 2vufB-6feaA:
1.3		 2vufB-6feaA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 7 TYR A 272
GLU A 196
LEU A 268
ASN A 206
 None
 1.43A 3k8mB-6feaA:
undetectable		 3k8mB-6feaA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 SER A  45
ARG A 259
GLY A 337
GLU A 366
 None
None
CO3  A 503 (-3.7A)
None
 1.11A 3k9fA-6feaA:
undetectable
3k9fB-6feaA:
undetectable
3k9fD-6feaA:
3.6		 3k9fA-6feaA:
10.91
3k9fB-6feaA:
10.91
3k9fD-6feaA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii) 		3 / 3 GLU C  85
LEU C  88
ASP C  89
 None
 0.39A 3ko0T-6feaC:
undetectable		 3ko0T-6feaC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 ILE A 279
VAL A 254
TYR A 223
ILE A 291
ILE A 294
 None
 1.22A 3p4wD-6feaA:
undetectable		 3p4wD-6feaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 ASP A 320
VAL A 437
LEU A 439
MET A 443
LEU A 351
 None
 1.21A 3s79A-6feaA:
undetectable		 3s79A-6feaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 ASN A 184
HIS A 180
GLY A  53
GLY A 237
ASN A  93
 None
D6N  A 502 (-4.6A)
None
None
None
 1.27A 3v3oA-6feaA:
undetectable		 3v3oA-6feaA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 11 ASN A 184
HIS A 180
GLY A  53
GLY A 237
ASN A  93
 None
D6N  A 502 (-4.6A)
None
None
None
 1.35A 4a99D-6feaA:
2.9		 4a99D-6feaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		4 / 6 ASP C  97
ASP A  27
ARG A  29
GLU C  14
 None
None
None
MG  C 201 ( 4.8A)
 1.15A 4eysA-6feaC:
undetectable		 4eysA-6feaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 PHE A 403
VAL A 420
LEU A 326
TYR A 430
 None
 1.17A 4f5zA-6feaA:
undetectable		 4f5zA-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii) 		5 / 12 GLN C   3
LEU C   9
GLY C  90
PHE C  86
ILE C  84
 None
 1.14A 4hytA-6feaC:
undetectable		 4hytA-6feaC:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii) 		5 / 12 GLN C   3
LEU C   9
GLY C  90
PHE C  86
ILE C  84
 None
 1.13A 4hytC-6feaC:
2.9		 4hytC-6feaC:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PHE A 164
ARG A 271
LEU A 268
ILE A 264
LEU A 183
 None
 1.43A 4k39A-6feaA:
undetectable		 4k39A-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 SER A 261
ASP A 367
ASP A 383
 None
 0.82A 4mwzA-6feaA:
undetectable		 4mwzA-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 LEU A 244
ASN A 206
LEU A 268
GLU A 267
 None
 1.21A 4nc3A-6feaA:
undetectable		 4nc3A-6feaA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 ALA A 258
ASN A 266
ARG A 276
HIS A 364
 None
 1.14A 5db5A-6feaA:
undetectable
5db5B-6feaA:
undetectable		 5db5A-6feaA:
undetectable
5db5B-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 TRP A 187
LEU A  62
THR A  65
TYR A 135
CYH A 168
 None
 1.37A 5dsgB-6feaA:
undetectable		 5dsgB-6feaA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 5 PHE A 433
ARG A 292
ILE A 291
ILE A 308
 None
 1.08A 5dzk4-6feaA:
undetectable
5dzkg-6feaA:
undetectable
5dzkm-6feaA:
undetectable
5dzkn-6feaA:
undetectable		 5dzk4-6feaA:
undetectable
5dzkg-6feaA:
undetectable
5dzkm-6feaA:
undetectable
5dzkn-6feaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii) 		4 / 6 ARG C  16
ASP A 350
GLY A 283
ASP A 280
 None
 1.10A 5hp1A-6feaC:
undetectable		 5hp1A-6feaC:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG
(Azotobacter
vinelandii) 		5 / 12 GLU C 107
ASP A 367
GLY A 363
ASN A  36
ALA A  50
 None
 1.19A 5kc4A-6feaC:
2.6		 5kc4A-6feaC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6fea NITROGENASE PROTEIN
ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 7 LEU A 244
ASN A 206
VAL A 231
GLN A 249
GLU A 193
 None
 1.47A 5tudA-6feaA:
undetectable		 5tudA-6feaA:
11.26