SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.73A 1muoA-6fekA:
7.7		 1muoA-6fekA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 ASN A 879
HIS A 872
PHE A 893
ILE A 858
 None
 1.21A 1tdnA-6fekA:
undetectable		 1tdnA-6fekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
ALA A 807
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 (-3.6A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.53A 1xbbA-6fekA:
33.8		 1xbbA-6fekA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 LEU A 941
LEU A 851
MET A1008
 None
 0.78A 1ya3B-6fekA:
undetectable		 1ya3B-6fekA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 11 GLY A 731
GLY A 733
VAL A 738
ALA A 756
TYR A 806
ALA A 807
SER A 811
LEU A 881
 ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.50A 2evaA-6fekA:
27.5		 2evaA-6fekA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
GLU A 775
LEU A 802
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.69A 2itoA-6fekA:
32.2		 2itoA-6fekA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		10 / 12 LEU A 730
GLY A 731
VAL A 738
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
None
None
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.32A 2ivuA-6fekA:
45.5		 2ivuA-6fekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LYS A 728
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 None
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
ADN  A1104 ( 4.8A)
 0.77A 2y6oA-6fekA:
31.6		 2y6oA-6fekA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		9 / 12 LEU A 730
GLY A 731
GLY A 733
GLY A 736
VAL A 738
ALA A 756
SER A 811
ASN A 879
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
None
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 (-3.7A)
None
ADN  A1104 (-4.3A)
 0.63A 3eygA-6fekA:
33.8		 3eygA-6fekA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		9 / 12 LEU A 730
GLY A 731
GLY A 733
GLY A 736
VAL A 738
ALA A 756
TYR A 806
SER A 811
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
None
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.64A 3fupA-6fekA:
33.4		 3fupA-6fekA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 11 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.75A 3g0fA-6fekA:
31.8		 3g0fA-6fekA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 10 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.58A 3g0fB-6fekA:
31.8		 3g0fB-6fekA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.45A 3g5dA-6fekA:
32.3		 3g5dA-6fekA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 LEU A 802
GLU A 775
LEU A 772
ASP A 771
ASP A 874
 None
 1.26A 3ko0A-6fekA:
undetectable
3ko0B-6fekA:
undetectable
3ko0C-6fekA:
undetectable
3ko0D-6fekA:
undetectable		 3ko0A-6fekA:
23.53
3ko0B-6fekA:
23.53
3ko0C-6fekA:
23.53
3ko0D-6fekA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ASP A 874
LEU A 802
GLU A 775
LEU A 772
ASP A 771
 None
 1.23A 3ko0G-6fekA:
undetectable
3ko0H-6fekA:
undetectable
3ko0I-6fekA:
undetectable
3ko0J-6fekA:
undetectable		 3ko0G-6fekA:
23.53
3ko0H-6fekA:
23.53
3ko0I-6fekA:
23.53
3ko0J-6fekA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ASP A 874
GLU A 775
LEU A 772
ASP A 771
LEU A 802
 None
 1.24A 3ko0M-6fekA:
undetectable
3ko0N-6fekA:
undetectable
3ko0O-6fekA:
undetectable
3ko0P-6fekA:
undetectable		 3ko0M-6fekA:
23.53
3ko0N-6fekA:
23.53
3ko0O-6fekA:
23.53
3ko0P-6fekA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		9 / 12 LEU A 730
GLY A 731
GLY A 733
VAL A 738
ALA A 756
ILE A 788
TYR A 806
SER A 811
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.55A 3lxnA-6fekA:
32.6		 3lxnA-6fekA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 3.8A)
 0.78A 3ohtB-6fekA:
16.6		 3ohtB-6fekA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.52A 3qlgB-6fekA:
32.0		 3qlgB-6fekA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
TYR A 806
LEU A 865
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
None
 0.78A 3rgfA-6fekA:
21.1		 3rgfA-6fekA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 VAL A 738
ALA A 756
LEU A 779
ILE A 788
TYR A 806
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
None
None
 0.89A 3rgfA-6fekA:
21.1		 3rgfA-6fekA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.40A 3sxrA-6fekA:
31.9		 3sxrA-6fekA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.44A 3sxrB-6fekA:
31.5		 3sxrB-6fekA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
 0.93A 3wzdA-6fekA:
32.0		 3wzdA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
 0.74A 3wzdA-6fekA:
32.0		 3wzdA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
VAL A 804
GLY A 810
PHE A 893
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
 0.96A 3wzdA-6fekA:
32.0		 3wzdA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
 0.55A 3wzdA-6fekA:
32.0		 3wzdA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
 0.57A 3wzdA-6fekA:
32.0		 3wzdA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
None
 0.56A 3wzeA-6fekA:
32.6		 3wzeA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
None
 0.58A 3wzeA-6fekA:
32.6		 3wzeA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
 0.50A 4agcA-6fekA:
31.9		 4agcA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.58A 4agcA-6fekA:
31.9		 4agcA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 11 LEU A 730
ALA A 756
VAL A 804
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.41A 4agdA-6fekA:
31.7		 4agdA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
None
None
 0.79A 4asdA-6fekA:
31.9		 4asdA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
None
 0.67A 4asdA-6fekA:
31.9		 4asdA-6fekA:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		9 / 10 LEU A 730
GLY A 731
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
SER A 811
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.18A 4ckjA-6fekA:
44.9		 4ckjA-6fekA:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 6 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 (-4.3A)
 0.58A 4o0wA-6fekA:
26.3		 4o0wA-6fekA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 LEU A 816
MET A 984
MET A 980
ILE A 890
 None
 0.84A 4ok1A-6fekA:
undetectable		 4ok1A-6fekA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
GLU A 775
VAL A 804
LEU A 865
ARG A 873
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
None
FMT  A1101 (-2.8A)
 1.05A 4qrcA-6fekA:
34.4		 4qrcA-6fekA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
HIS A 872
LEU A 881
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
ADN  A1104 (-4.3A)
 0.30A 4tyjA-6fekA:
34.1		 4tyjA-6fekA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.46A 4u5jB-6fekA:
32.4		 4u5jB-6fekA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
VAL A 804
LEU A 865
HIS A 872
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
None
None
ADN  A1104 (-4.3A)
 0.55A 4uxqA-6fekA:
34.1		 4uxqA-6fekA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 VAL A 738
ILE A 788
ALA A 807
ILE A 890
 ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 (-3.6A)
None
 0.41A 4uxqA-6fekA:
34.1		 4uxqA-6fekA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.57A 4v01A-6fekA:
32.6		 4v01A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 0.98A 4v01A-6fekA:
32.6		 4v01A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.57A 4v01B-6fekA:
33.2		 4v01B-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ILE A 788
TYR A 806
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-4.3A)
None
 0.48A 4v01B-6fekA:
33.2		 4v01B-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
HIS A 872
GLY A 894
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 1.45A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.78A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 8 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 1.37A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 10 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 1.17A 4v04B-6fekA:
33.3		 4v04B-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.90A 4v04B-6fekA:
33.3		 4v04B-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 LEU A 730
ALA A 756
LEU A 881
SER A 891
 ADN  A1104 ( 4.0A)
ADN  A1104 (-3.4A)
ADN  A1104 (-4.3A)
ADN  A1104 ( 4.8A)
 0.78A 4wboB-6fekA:
24.6		 4wboB-6fekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 LEU A 816
ARG A 820
ARG A 844
 None
 0.71A 4yiaB-6fekA:
undetectable		 4yiaB-6fekA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
GLU A 775
ILE A 788
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.52A 5i9xA-6fekA:
30.9		 5i9xA-6fekA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
ADN  A1104 ( 4.8A)
 0.37A 5i9yA-6fekA:
26.6		 5i9yA-6fekA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 11 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.52A 5lvnA-6fekA:
27.8		 5lvnA-6fekA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LEU A 802
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 (-4.3A)
 0.55A 5yu9A-6fekA:
28.4		 5yu9A-6fekA:
30.00