SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6feq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 101
 None
 1.21A 1ncwH-6feqD:
21.6
1ncwL-6feqD:
14.4		 1ncwH-6feqD:
undetectable
1ncwL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 104
 None
 1.04A 1ncwH-6feqD:
21.6
1ncwL-6feqD:
14.4		 1ncwH-6feqD:
undetectable
1ncwL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 10 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 101
 None
 1.20A 1ruaH-6feqD:
22.1
1ruaL-6feqD:
14.5		 1ruaH-6feqD:
undetectable
1ruaL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 101
 None
 1.18A 1rulH-6feqD:
21.9
1rulL-6feqD:
14.4		 1rulH-6feqD:
undetectable
1rulL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 104
 None
 1.01A 1rulH-6feqD:
21.9
1rulL-6feqD:
14.4		 1rulH-6feqD:
undetectable
1rulL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 101
 None
 1.20A 1rumH-6feqD:
21.7
1rumL-6feqD:
14.5		 1rumH-6feqD:
undetectable
1rumL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 104
 None
 1.04A 1rumH-6feqD:
21.7
1rumL-6feqD:
14.5		 1rumH-6feqD:
undetectable
1rumL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 101
 None
 1.20A 1rupH-6feqD:
21.5
1rupL-6feqD:
14.5		 1rupH-6feqD:
undetectable
1rupL-6feqD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6feq 5D3(FAB) HEAVY CHAIN
VARIABLE DOMAIN
(Mus
musculus) 		5 / 9 ALA D  34
ASN D  36
TRP D  48
TYR D  51
GLY D 104
 None
 1.02A 1rupH-6feqD:
21.5
1rupL-6feqD:
14.5		 1rupH-6feqD:
undetectable
1rupL-6feqD:
undetectable