SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 8 SER A1855
SER A1854
GLY A1851
ARG A1846
 None
 0.97A 1meiA-6fghA:
undetectable		 1meiA-6fghA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.19A 2nsiA-6fghA:
undetectable
2nsiB-6fghA:
undetectable		 2nsiA-6fghA:
14.20
2nsiB-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.19A 2nsiA-6fghA:
undetectable
2nsiB-6fghA:
undetectable		 2nsiA-6fghA:
14.20
2nsiB-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.19A 2nsiC-6fghA:
undetectable
2nsiD-6fghA:
undetectable		 2nsiC-6fghA:
14.20
2nsiD-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.17A 2nsiC-6fghA:
undetectable
2nsiD-6fghA:
undetectable		 2nsiC-6fghA:
14.20
2nsiD-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.15A 3e7gA-6fghA:
undetectable
3e7gB-6fghA:
undetectable		 3e7gA-6fghA:
14.24
3e7gB-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.18A 3e7gA-6fghA:
undetectable
3e7gB-6fghA:
undetectable		 3e7gA-6fghA:
14.24
3e7gB-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.24A 3e7gC-6fghA:
undetectable
3e7gD-6fghA:
undetectable		 3e7gC-6fghA:
14.24
3e7gD-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 8 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.12A 3e7gC-6fghA:
undetectable
3e7gD-6fghA:
undetectable		 3e7gC-6fghA:
14.24
3e7gD-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 8 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.37A 4cx7A-6fghA:
undetectable
4cx7B-6fghA:
undetectable		 4cx7A-6fghA:
14.20
4cx7B-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 8 PHE A1889
HIS A1812
GLU A1810
ILE A1805
 None
 0.86A 4cx7A-6fghA:
undetectable
4cx7B-6fghA:
undetectable		 4cx7A-6fghA:
14.20
4cx7B-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 8 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.27A 4cx7C-6fghA:
undetectable
4cx7D-6fghA:
undetectable		 4cx7C-6fghA:
14.20
4cx7D-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.36A 4cx7C-6fghA:
undetectable
4cx7D-6fghA:
undetectable		 4cx7C-6fghA:
14.20
4cx7D-6fghA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 PHE A1889
GLU A1810
MET A1807
ILE A1805
 None
 1.37A 4nosA-6fghA:
undetectable
4nosB-6fghA:
undetectable		 4nosA-6fghA:
14.24
4nosB-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		4 / 7 MET A1807
ILE A1805
PHE A1889
GLU A1810
 None
 1.28A 4nosC-6fghA:
undetectable
4nosD-6fghA:
undetectable		 4nosC-6fghA:
14.24
4nosD-6fghA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		3 / 3 TRP A1894
GLU A1856
ASP A1798
 None
 0.98A 5gqbA-6fghA:
undetectable		 5gqbA-6fghA:
8.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 6fgh BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2A
(Homo
sapiens) 		5 / 6 PRO A1817
VAL A1822
VAL A1827
TYR A1830
ASN A1873
 6RZ  A1901 (-4.8A)
6RZ  A1901 (-3.8A)
6RZ  A1901 ( 4.8A)
6RZ  A1901 ( 4.8A)
6RZ  A1901 (-3.2A)
 0.46A 5pbeA-6fghA:
19.5		 5pbeA-6fghA:
45.45