SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 6fhe -
(-) 		3 / 3 VAL A  93
VAL A 155
TRP A 167
 None
 0.84A 1av2C-6fheA:
undetectable
1av2D-6fheA:
undetectable		 1av2C-6fheA:
undetectable
1av2D-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6fhe -
(-) 		5 / 10 GLY A 226
VAL A 227
GLY A 228
MET A 229
VAL A 255
 None
 1.03A 1pwyE-6fheA:
undetectable		 1pwyE-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6fhe -
(-) 		5 / 10 VAL A 227
GLY A 228
MET A 229
THR A 297
VAL A 255
 None
 1.21A 1pwyE-6fheA:
undetectable		 1pwyE-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6fhe -
(-) 		5 / 10 GLY A 226
VAL A 227
GLY A 228
MET A 229
VAL A 255
 None
 1.11A 1v3qE-6fheA:
undetectable		 1v3qE-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6fhe -
(-) 		5 / 10 VAL A 227
GLY A 228
MET A 229
THR A 297
VAL A 255
 None
 1.24A 1v3qE-6fheA:
undetectable		 1v3qE-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 6fhe -
(-) 		3 / 3 VAL A  93
VAL A 155
TRP A 167
 None
 0.85A 1w5uC-6fheA:
undetectable
1w5uD-6fheA:
undetectable		 1w5uC-6fheA:
undetectable
1w5uD-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6fhe -
(-) 		4 / 5 ILE A 194
ILE A 296
ILE A 199
MET A 210
 None
 0.81A 1zgyA-6fheA:
undetectable		 1zgyA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 6fhe -
(-) 		3 / 3 VAL A 155
TRP A 167
VAL A  93
 None
 0.88A 2izqA-6fheA:
undetectable
2izqB-6fheA:
undetectable		 2izqA-6fheA:
undetectable
2izqB-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 6fhe -
(-) 		5 / 12 ILE A 296
ARG A 283
PHE A 289
ILE A 233
LEU A 262
 None
 1.07A 2w3bA-6fheA:
undetectable		 2w3bA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 6fhe -
(-) 		4 / 6 ARG A  75
ASP A  72
GLN A  97
GLU A  53
 None
 1.16A 2ya7C-6fheA:
undetectable		 2ya7C-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 6fhe -
(-) 		3 / 3 VAL A  93
VAL A 155
TRP A 167
 None
 0.89A 3l8lC-6fheA:
undetectable
3l8lD-6fheA:
undetectable		 3l8lC-6fheA:
undetectable
3l8lD-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 6fhe -
(-) 		4 / 6 PHE A  47
PHE A 326
HIS A  39
THR A  43
 None
 1.24A 3lb3A-6fheA:
undetectable		 3lb3A-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 6fhe -
(-) 		4 / 6 PHE A  47
PHE A 326
HIS A  39
THR A  43
 None
 1.32A 3lb3B-6fheA:
undetectable		 3lb3B-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fhe -
(-) 		5 / 11 PRO A  38
LEU A  33
VAL A  28
ALA A  27
THR A  43
 None
 1.25A 3n23C-6fheA:
undetectable		 3n23C-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6fhe -
(-) 		4 / 6 ILE A 199
GLU A 200
ALA A 246
ASN A 201
 None
 1.14A 3pgyA-6fheA:
undetectable
3pgyB-6fheA:
undetectable		 3pgyA-6fheA:
undetectable
3pgyB-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 6fhe -
(-) 		4 / 7 ASN A  34
ALA A  40
THR A  43
LEU A  50
 None
 0.89A 3t3sC-6fheA:
undetectable		 3t3sC-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 6fhe -
(-) 		4 / 8 ASN A  34
ALA A  40
THR A  43
LEU A  50
 None
 0.90A 4ejgB-6fheA:
undetectable		 4ejgB-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 6fhe -
(-) 		4 / 6 ASN A  34
ALA A  40
THR A  43
LEU A  50
 None
 0.84A 4ejgD-6fheA:
undetectable		 4ejgD-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 6fhe -
(-) 		3 / 3 LYS A 333
LEU A 275
ALA A 335
 None
 0.64A 4iizA-6fheA:
undetectable		 4iizA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 6fhe -
(-) 		3 / 3 GLU A  62
TRP A 101
LYS A 136
 None
 1.48A 4k7aA-6fheA:
undetectable		 4k7aA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 6fhe -
(-) 		3 / 3 TYR A 197
GLN A  96
TRP A 302
 None
 1.14A 4kn2C-6fheA:
undetectable		 4kn2C-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6fhe -
(-) 		5 / 12 ILE A 296
LEU A 288
PHE A 289
ILE A 233
ILE A 259
 None
 1.08A 4ptjA-6fheA:
undetectable		 4ptjA-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 6fhe -
(-) 		4 / 5 ASP A 196
VAL A 214
PHE A 250
GLY A 226
 None
 1.13A 4xp6A-6fheA:
undetectable		 4xp6A-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 6fhe -
(-) 		5 / 12 PHE A 193
TYR A 175
PHE A 217
VAL A 224
VAL A 255
 None
 1.36A 6hu9N-6fheA:
undetectable		 6hu9N-6fheA:
undetectable