SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.36A 1a52A-6fhsA:
undetectable		 1a52A-6fhsA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.40A 1a52B-6fhsA:
undetectable		 1a52B-6fhsA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 LEU J 702
LEU J 657
VAL J 658
VAL J 686
LEU J 683
 None
 1.29A 1db1A-6fhsJ:
undetectable		 1db1A-6fhsJ:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.37A 1ereA-6fhsA:
undetectable		 1ereA-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.37A 1ereB-6fhsA:
undetectable		 1ereB-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.38A 1ereC-6fhsA:
undetectable		 1ereC-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.38A 1ereD-6fhsA:
undetectable		 1ereD-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.80A 1grmA-6fhsG:
undetectable		 1grmA-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.80A 1grmB-6fhsG:
undetectable		 1grmB-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 8 GLY J 765
LEU J 225
VAL J 218
PHE J 193
 None
 0.70A 1gsfA-6fhsJ:
undetectable		 1gsfA-6fhsJ:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 8 GLY J 765
LEU J 225
VAL J 218
PHE J 193
 None
 0.70A 1gsfB-6fhsJ:
undetectable		 1gsfB-6fhsJ:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 8 GLY J 765
LEU J 225
VAL J 218
PHE J 193
 None
 0.70A 1gsfD-6fhsJ:
undetectable		 1gsfD-6fhsJ:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 7 GLY J 690
SER J 207
HIS J 214
ALA J 161
 None
 0.87A 1gxsA-6fhsJ:
undetectable
1gxsB-6fhsJ:
undetectable		 1gxsA-6fhsJ:
undetectable
1gxsB-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.93A 1jo4A-6fhsG:
undetectable		 1jo4A-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.93A 1jo4B-6fhsG:
undetectable		 1jo4B-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.94A 1magA-6fhsG:
undetectable		 1magA-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 6fhs INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.94A 1magB-6fhsG:
undetectable		 1magB-6fhsG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.35A 1qkuA-6fhsA:
undetectable		 1qkuA-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.35A 1qkuB-6fhsA:
undetectable		 1qkuB-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.35A 1qkuC-6fhsA:
undetectable		 1qkuC-6fhsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 ILE J 175
ASP J 137
PHE J 140
 None
 0.58A 1uwjB-6fhsJ:
undetectable		 1uwjB-6fhsJ:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 GLY A  76
GLY A  71
GLN A  43
THR A 364
ILE A 375
 ADP  A 501 (-3.2A)
None
None
None
ADP  A 501 (-3.9A)
 1.35A 2azxA-6fhsA:
undetectable		 2azxA-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 GLY A  76
GLY A  71
GLN A  43
THR A 364
ILE A 375
 ADP  A 501 (-3.2A)
None
None
None
ADP  A 501 (-3.9A)
 1.30A 2azxB-6fhsA:
undetectable		 2azxB-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 PHE J 119
LEU J 136
PHE J 140
ILE J 156
ALA J  70
 None
 1.24A 2bxpA-6fhsJ:
undetectable		 2bxpA-6fhsJ:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 6fhs RUVB-LIKE HELICASE
INO80
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 GLY A 199
GLY A 253
GLY A 254
ASP A 243
PRO G1282
 None
 1.07A 2dpmA-6fhsA:
undetectable		 2dpmA-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 6fhs INO80
RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE G1288
THR A 128
GLU A 127
GLU G1290
 None
 1.32A 2dttB-6fhsG:
undetectable
2dttC-6fhsG:
undetectable		 2dttB-6fhsG:
16.10
2dttC-6fhsG:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 6fhs RUVB-LIKE HELICASE
INO80
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 ASP A 245
LEU A 244
ARG A 118
SER G1309
ALA G1469
 None
 1.07A 2ejtA-6fhsA:
undetectable		 2ejtA-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 ARG J  79
ILE J  61
ILE J 156
ARG J  48
GLU J  75
 None
 1.14A 2j0dA-6fhsJ:
undetectable		 2j0dA-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 ILE J  61
ILE J 156
ALA J  49
ARG J  48
GLU J  75
 None
 1.13A 2j0dA-6fhsJ:
undetectable		 2j0dA-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 5 TRP J 735
ALA J 743
LEU J 764
ALA J 744
 None
 1.07A 2jstA-6fhsJ:
undetectable
2jstB-6fhsJ:
undetectable		 2jstA-6fhsJ:
19.05
2jstB-6fhsJ:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6fhs ARP5
(Chaetomium
thermophilum) 		6 / 12 ALA J 239
GLY J 122
SER J 211
GLY J 234
GLY J 235
ALA J 121
 None
None
ATP  J 801 (-3.0A)
None
ATP  J 801 ( 3.7A)
None
 1.37A 3douA-6fhsJ:
2.1		 3douA-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		6 / 12 VAL A  53
ALA A  83
GLN A  86
PHE A  94
LEU A  88
VAL A  67
 None
 1.43A 3fc6C-6fhsA:
undetectable		 3fc6C-6fhsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 6fhs ARP5
(Chaetomium
thermophilum) 		6 / 12 LEU J 143
GLY J 144
ARG J  46
ILE J  59
ALA J  49
ASP J 153
 None
 1.13A 3gwvA-6fhsJ:
undetectable		 3gwvA-6fhsJ:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 GLN A 409
ILE A 375
LEU A 387
VAL A 385
VAL A 426
 None
ADP  A 501 (-3.9A)
None
None
None
 1.07A 3gwxA-6fhsA:
undetectable		 3gwxA-6fhsA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 LEU J 726
TRP J 729
GLY J  71
 None
 0.66A 3l35A-6fhsJ:
undetectable
3l35H-6fhsJ:
undetectable		 3l35A-6fhsJ:
undetectable
3l35H-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 LEU J 726
TRP J 729
GLY J  71
 None
 0.61A 3l35B-6fhsJ:
undetectable
3l35K-6fhsJ:
undetectable		 3l35B-6fhsJ:
undetectable
3l35K-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		3 / 3 GLU A 101
GLU A 115
ASN A 116
 None
 0.74A 3lp9B-6fhsA:
undetectable
3lp9D-6fhsA:
undetectable		 3lp9B-6fhsA:
15.86
3lp9D-6fhsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 GLY A  64
ALA A  63
ILE A 324
GLY A 298
ILE A  57
 None
 0.99A 3ogpA-6fhsA:
undetectable		 3ogpA-6fhsA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 5 TYR A 315
THR A 314
PHE A 313
LEU A 320
 None
 0.66A 3qelC-6fhsA:
undetectable		 3qelC-6fhsA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 6 ALA J 223
ILE J 216
LEU J 192
GLU J 761
 None
 0.82A 3r9sC-6fhsJ:
undetectable		 3r9sC-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 9 PRO J 711
GLY J 713
ALA J 714
ARG J 684
LEU J 683
 None
 1.20A 3ur0C-6fhsJ:
undetectable		 3ur0C-6fhsJ:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 ILE A 181
ALA A 180
LEU A 173
LEU A 171
LEU A 162
 None
 0.87A 3uvvA-6fhsA:
undetectable		 3uvvA-6fhsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 8 VAL J  68
MET J 158
ILE J  61
ASN J  63
 None
 0.73A 4a97D-6fhsJ:
undetectable		 4a97D-6fhsJ:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 8 VAL J  68
MET J 158
ILE J  61
ASN J  63
 None
 0.82A 4a97I-6fhsJ:
undetectable		 4a97I-6fhsJ:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 6fhs INO80
RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 8 GLN A 263
LYS A 202
ASN G1539
THR G1538
 None
 1.13A 4d1yA-6fhsA:
undetectable
4d1yB-6fhsA:
undetectable		 4d1yA-6fhsA:
19.10
4d1yB-6fhsA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 9 SER J 207
GLY J 690
SER J 209
ASP J 190
THR J 689
 None
None
ATP  J 801 (-3.7A)
ATP  J 801 (-3.3A)
None
 1.21A 4lb0A-6fhsJ:
undetectable		 4lb0A-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 6fhs INO80
(Chaetomium
thermophilum) 		4 / 7 ARG G1308
VAL G1477
GLU G1312
ARG G1314
 None
 1.22A 4mv7A-6fhsG:
undetectable		 4mv7A-6fhsG:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 8 ILE A 302
PHE A 355
LEU A 330
LEU A 320
 None
 0.94A 4qopC-6fhsA:
undetectable		 4qopC-6fhsA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 ASP A 393
GLU A 371
GLY A 399
GLU A 435
ILE A 431
 None
 1.26A 4xe5A-6fhsA:
undetectable		 4xe5A-6fhsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 ILE J  59
ALA J  58
ALA J 732
ASN J  73
PHE J 140
 None
 1.29A 4zo1X-6fhsJ:
undetectable		 4zo1X-6fhsJ:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 HIS J 762
GLU J 740
TRP J 735
 None
 0.87A 5odiD-6fhsJ:
undetectable		 5odiD-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 HIS J 762
GLU J 740
TRP J 735
 None
 0.90A 5odqD-6fhsJ:
undetectable		 5odqD-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6fhs ARP5
(Chaetomium
thermophilum) 		3 / 3 HIS J 762
GLU J 740
TRP J 735
 None
 0.86A 5odrD-6fhsJ:
undetectable		 5odrD-6fhsJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 6fhs ARP5
(Chaetomium
thermophilum) 		5 / 12 GLU J 641
PHE J 698
ARG J 230
GLY J 656
LEU J 657
 None
 1.08A 5ogcB-6fhsJ:
undetectable		 5ogcB-6fhsJ:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		6 / 12 ILE A  84
ALA A  83
GLN A  86
PHE A  94
LEU A  88
VAL A  67
 None
 1.38A 5uanA-6fhsA:
undetectable		 5uanA-6fhsA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 6fhs ARP5
(Chaetomium
thermophilum) 		4 / 4 PHE J 612
LEU J 258
LEU J 245
VAL J 630
 None
 1.34A 5xxiA-6fhsJ:
undetectable		 5xxiA-6fhsJ:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6fhs RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		3 / 3 GLY A 161
THR A 137
GLU A 138
 None
 0.66A 6b58A-6fhsA:
undetectable		 6b58A-6fhsA:
undetectable