SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_D_DCFD1853_2 (ADENOSINE DEAMINASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 4	HIS A 334 LEU A 379 LEU A 370 LEU A 498	None	1.23A	1a4lD-6fhtA: undetectable	1a4lD-6fhtA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	LEU A 498 LEU A 438 ALA A 339 SER A 347 PRO A 348	None	1.04A	1dfoA-6fhtA: undetectable	1dfoA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	LEU A 498 LEU A 438 ALA A 339 SER A 347 PRO A 348	None	1.04A	1dfoB-6fhtA: undetectable	1dfoB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	LEU A 498 LEU A 438 ALA A 339 SER A 347 PRO A 348	None	1.04A	1dfoC-6fhtA: undetectable	1dfoC-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	LEU A 498 LEU A 438 ALA A 339 SER A 347 PRO A 348	None	1.04A	1dfoD-6fhtA: undetectable	1dfoD-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_A_ACTA3003_0 (BETA-CARBONIC ANHYDRASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 8	ASP A 171 VAL A 173 HIS A 291 GLY A 169	None None 12P A 808 (-4.6A) 12P A 808 (-3.6A)	0.92A	1ekjA-6fhtA: undetectable 1ekjB-6fhtA: undetectable	1ekjA-6fhtA: undetectable 1ekjB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_A_CHDA1502_0 (FERROCHELATASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 8	ARG A 192 LEU A 195 VAL A 269 GLY A 270	None	0.90A	1hrkA-6fhtA: undetectable	1hrkA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2502_0 (FERROCHELATASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 8	ARG A 192 LEU A 195 VAL A 269 GLY A 270	None	0.88A	1hrkB-6fhtA: undetectable	1hrkB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZ4_A_BEZA784_0 (MALT REGULATORY PROTEIN)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 6	HIS A 116 LEU A 89 LEU A 97 PRO A 94	None	1.29A	1hz4A-6fhtA: undetectable	1hz4A-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P5Z_B_AR3B304_1 (DEOXYCYTIDINE KINASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	ILE A 595 GLU A 676 LEU A 550 TYR A 572 GLN A 620	None	1.20A	1p5zB-6fhtA: undetectable	1p5zB-6fhtA: 16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_A_VIBA501_1 (YKOF)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 8	ILE A 684 ILE A 686 THR A 544 THR A 646	None	0.90A	1sbrA-6fhtA: 3.3	1sbrA-6fhtA: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB503_1 (YKOF)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 7	ILE A 684 ILE A 686 THR A 544 THR A 646	None	0.91A	1sbrB-6fhtA: 3.8	1sbrB-6fhtA: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NO6_A_ETVA302_1 (DEOXYCYTIDINE KINASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	ILE A 595 GLU A 676 LEU A 550 TYR A 572 GLN A 620	None	1.26A	2no6A-6fhtA: undetectable	2no6A-6fhtA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NOA_A_3TCA302_1 (DEOXYCYTIDINE KINASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	ILE A 595 GLU A 676 LEU A 550 TYR A 572 GLN A 620	None	1.28A	2noaA-6fhtA: undetectable	2noaA-6fhtA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YS6_A_GLYA431_0 (PHOSPHORIBOSYLGLYCIN AMIDE SYNTHETASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 8	ASP A 207 TYR A 176 GLY A 184 PRO A 204	LBV A 801 (-3.9A) LBV A 801 (-4.5A) None None	0.97A	2ys6A-6fhtA: undetectable	2ys6A-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_A_CHDA2_0 (FERROCHELATASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 6	ARG A 172 PRO A 456 GLY A 452 TRP A 451	None	1.45A	3aqiA-6fhtA: undetectable	3aqiA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	6 / 12	LEU A 610 HIS A 582 GLY A 616 ILE A 686 VAL A 723 GLY A 643	None	1.25A	3bwcB-6fhtA: undetectable	3bwcB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	6 / 12	LEU A 610 ILE A 642 GLY A 616 ILE A 686 VAL A 723 GLY A 643	None	1.46A	3bwcB-6fhtA: undetectable	3bwcB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CWK_A_REAA300_1 (CELLULAR RETINOIC ACID-BINDING PROTEIN 2)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	LEU A 357 ALA A 341 ALA A 339 THR A 497 GLU A 490	None	1.24A	3cwkA-6fhtA: undetectable	3cwkA-6fhtA: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_A_TRPA1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 10	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.33A	3fhjA-6fhtA: undetectable	3fhjA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_B_TRPB1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 10	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.36A	3fhjB-6fhtA: undetectable	3fhjB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_C_TRPC1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 10	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.32A	3fhjC-6fhtA: undetectable	3fhjC-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHJ_E_TRPE1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 10	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.32A	3fhjE-6fhtA: undetectable	3fhjE-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PS9_A_SAMA670_1 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 6	GLY A 585 THR A 586 LEU A 598 ASP A 608	None	0.97A	3ps9A-6fhtA: undetectable	3ps9A-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEO_B_LLTB261_1 (DEOXYCYTIDINE KINASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 7	GLU A 320 VAL A 316 LEU A 312 LEU A 283	None	0.98A	3qeoB-6fhtA: undetectable	3qeoB-6fhtA: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZS_A_SAMA1475_0 (METHYLTRANSFERASE WBDD)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	TYR A 479 GLY A 424 ALA A 423 ARG A 364 GLU A 487	None	1.19A	4azsA-6fhtA: undetectable	4azsA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZW_A_SAMA1451_0 (WBDD)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	TYR A 479 GLY A 424 ALA A 423 ARG A 364 GLU A 487	None	1.25A	4azwA-6fhtA: undetectable	4azwA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 12	LEU A 220 TYR A 216 GLY A 285 GLY A 184 GLY A 281	None LBV A 801 (-4.5A) None None None	1.13A	4blvA-6fhtA: undetectable	4blvA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CUT_A_TYLA2971_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 4	VAL A 715 VAL A 711 ASN A 645 ILE A 675	None	1.23A	4cutA-6fhtA: undetectable	4cutA-6fhtA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FJP_A_NPSA711_1 (LACTOTRANSFERRIN)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 6	GLY A 600 PRO A 602 TYR A 662 GLY A 516	None	0.82A	4fjpA-6fhtA: undetectable	4fjpA-6fhtA: 13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I89_B_1FLB201_1 (TRANSTHYRETIN)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	4 / 4	LYS A -1 ALA A 182 SER A 206 THR A 183	None	1.08A	4i89B-6fhtA: undetectable	4i89B-6fhtA: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L9Q_B_9TPB601_1 (SERUM ALBUMIN)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	LEU A 370 PRO A 348 ALA A 501 LEU A 357 GLY A 361	None	1.22A	4l9qB-6fhtA: undetectable	4l9qB-6fhtA: 8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_D_29SD601_1 (ESTROGEN RECEPTOR)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	ALA A 427 LEU A 395 LEU A 392 ARG A 371 LEU A 408	None	1.30A	4xi3D-6fhtA: undetectable	4xi3D-6fhtA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGJ_A_CTYA402_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Deinococcus radiodurans; Synechocystis sp. PCC 6803)	5 / 12	ILE A 675 GLU A 648 ALA A 609 VAL A 613 GLY A 600	None	1.10A	5igjA-6fhtA: undetectable	5igjA-6fhtA: 11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0I_A_TRPA402_0 (TRYPTOPHAN--TRNA LIGASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 9	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.34A	5v0iA-6fhtA: undetectable	5v0iA-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0I_B_TRPB402_0 (TRYPTOPHAN--TRNA LIGASE)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	5 / 9	GLY A 616 GLN A 620 MET A 576 ILE A 580 VAL A 597	None	1.29A	5v0iB-6fhtA: undetectable	5v0iB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1808_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 5	LEU A 438 ALA A 427 LEU A 426 LEU A 395	None	0.80A	5vkqA-6fhtA: undetectable 5vkqD-6fhtA: undetectable	5vkqA-6fhtA: undetectable 5vkqD-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1805_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 5	LEU A 395 LEU A 438 ALA A 427 LEU A 426	None	0.81A	5vkqA-6fhtA: undetectable 5vkqB-6fhtA: undetectable	5vkqA-6fhtA: undetectable 5vkqB-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 5	LEU A 395 LEU A 438 ALA A 427 LEU A 426	None	0.78A	5vkqB-6fhtA: undetectable 5vkqC-6fhtA: undetectable	5vkqB-6fhtA: undetectable 5vkqC-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 5	LEU A 395 LEU A 438 ALA A 427 LEU A 426	None	0.84A	5vkqC-6fhtA: undetectable 5vkqD-6fhtA: undetectable	5vkqC-6fhtA: undetectable 5vkqD-6fhtA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_F_AM2F301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	6fht	BACTERIOPHYTOCHROME, ADENYLATE CYCLASE (Synechocystis sp. PCC 6803; Deinococcus radiodurans)	4 / 7	HIS A 38 ARG A 100 GLU A 127 GLU A 306	None	1.35A	6mn4F-6fhtA: undetectable	6mn4F-6fhtA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4L_D_DCFD1853_2","ADENOSINE DEAMINASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"HIS A 334;LEU A 379;LEU A 370;LEU A 498","None","1.23A","1a4lD-6fhtA:undetectable","1a4lD-6fhtA:13.20"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"LEU A 498;LEU A 438;ALA A 339;SER A 347;PRO A 348","None","1.04A","1dfoA-6fhtA:undetectable","1dfoA-6fhtA:undetectable"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"LEU A 498;LEU A 438;ALA A 339;SER A 347;PRO A 348","None","1.04A","1dfoB-6fhtA:undetectable","1dfoB-6fhtA:undetectable"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"LEU A 498;LEU A 438;ALA A 339;SER A 347;PRO A 348","None","1.04A","1dfoC-6fhtA:undetectable","1dfoC-6fhtA:undetectable"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"LEU A 498;LEU A 438;ALA A 339;SER A 347;PRO A 348","None","1.04A","1dfoD-6fhtA:undetectable","1dfoD-6fhtA:undetectable"],["1EKJ_A_ACTA3003_0","BETA-CARBONIC ANHYDRASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"ASP A 171;VAL A 173;HIS A 291;GLY A 169","None;None;12P A 808 (-4.6A);12P A 808 (-3.6A)","0.92A","1ekjA-6fhtA:undetectable;1ekjB-6fhtA:undetectable","1ekjA-6fhtA:undetectable;1ekjB-6fhtA:undetectable"],["1HRK_A_CHDA1502_0","FERROCHELATASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"ARG A 192;LEU A 195;VAL A 269;GLY A 270","None","0.90A","1hrkA-6fhtA:undetectable","1hrkA-6fhtA:undetectable"],["1HRK_B_CHDB2502_0","FERROCHELATASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"ARG A 192;LEU A 195;VAL A 269;GLY A 270","None","0.88A","1hrkB-6fhtA:undetectable","1hrkB-6fhtA:undetectable"],["1HZ4_A_BEZA784_0","MALT REGULATORY PROTEIN","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"HIS A 116;LEU A  89;LEU A  97;PRO A  94","None","1.29A","1hz4A-6fhtA:undetectable","1hz4A-6fhtA:undetectable"],["1P5Z_B_AR3B304_1","DEOXYCYTIDINE KINASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"ILE A 595;GLU A 676;LEU A 550;TYR A 572;GLN A 620","None","1.20A","1p5zB-6fhtA:undetectable","1p5zB-6fhtA:16.35"],["1SBR_A_VIBA501_1","YKOF","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"ILE A 684;ILE A 686;THR A 544;THR A 646","None","0.90A","1sbrA-6fhtA:3.3","1sbrA-6fhtA:17.58"],["1SBR_B_VIBB503_1","YKOF","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"ILE A 684;ILE A 686;THR A 544;THR A 646","None","0.91A","1sbrB-6fhtA:3.8","1sbrB-6fhtA:17.58"],["2NO6_A_ETVA302_1","DEOXYCYTIDINE KINASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"ILE A 595;GLU A 676;LEU A 550;TYR A 572;GLN A 620","None","1.26A","2no6A-6fhtA:undetectable","2no6A-6fhtA:15.05"],["2NOA_A_3TCA302_1","DEOXYCYTIDINE KINASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"ILE A 595;GLU A 676;LEU A 550;TYR A 572;GLN A 620","None","1.28A","2noaA-6fhtA:undetectable","2noaA-6fhtA:15.05"],["2YS6_A_GLYA431_0","PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"ASP A 207;TYR A 176;GLY A 184;PRO A 204","LBV A 801 (-3.9A);LBV A 801 (-4.5A);None;None","0.97A","2ys6A-6fhtA:undetectable","2ys6A-6fhtA:undetectable"],["3AQI_A_CHDA2_0","FERROCHELATASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"ARG A 172;PRO A 456;GLY A 452;TRP A 451","None","1.45A","3aqiA-6fhtA:undetectable","3aqiA-6fhtA:undetectable"],["3BWC_B_SAMB501_0","SPERMIDINE SYNTHASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",6,"LEU A 610;HIS A 582;GLY A 616;ILE A 686;VAL A 723;GLY A 643","None","1.25A","3bwcB-6fhtA:undetectable","3bwcB-6fhtA:undetectable"],["3BWC_B_SAMB501_0","SPERMIDINE SYNTHASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",6,"LEU A 610;ILE A 642;GLY A 616;ILE A 686;VAL A 723;GLY A 643","None","1.46A","3bwcB-6fhtA:undetectable","3bwcB-6fhtA:undetectable"],["3CWK_A_REAA300_1","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"LEU A 357;ALA A 341;ALA A 339;THR A 497;GLU A 490","None","1.24A","3cwkA-6fhtA:undetectable","3cwkA-6fhtA:19.84"],["3FHJ_A_TRPA1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.33A","3fhjA-6fhtA:undetectable","3fhjA-6fhtA:undetectable"],["3FHJ_B_TRPB1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.36A","3fhjB-6fhtA:undetectable","3fhjB-6fhtA:undetectable"],["3FHJ_C_TRPC1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.32A","3fhjC-6fhtA:undetectable","3fhjC-6fhtA:undetectable"],["3FHJ_E_TRPE1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.32A","3fhjE-6fhtA:undetectable","3fhjE-6fhtA:undetectable"],["3PS9_A_SAMA670_1","TRNA 5-METHYLAMINOMETHYL-2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"GLY A 585;THR A 586;LEU A 598;ASP A 608","None","0.97A","3ps9A-6fhtA:undetectable","3ps9A-6fhtA:undetectable"],["3QEO_B_LLTB261_1","DEOXYCYTIDINE KINASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"GLU A 320;VAL A 316;LEU A 312;LEU A 283","None","0.98A","3qeoB-6fhtA:undetectable","3qeoB-6fhtA:15.11"],["4AZS_A_SAMA1475_0","METHYLTRANSFERASE WBDD","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"TYR A 479;GLY A 424;ALA A 423;ARG A 364;GLU A 487","None","1.19A","4azsA-6fhtA:undetectable","4azsA-6fhtA:undetectable"],["4AZW_A_SAMA1451_0","WBDD","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"TYR A 479;GLY A 424;ALA A 423;ARG A 364;GLU A 487","None","1.25A","4azwA-6fhtA:undetectable","4azwA-6fhtA:undetectable"],["4BLV_A_SAMA1281_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"LEU A 220;TYR A 216;GLY A 285;GLY A 184;GLY A 281","None;LBV A 801 (-4.5A);None;None;None","1.13A","4blvA-6fhtA:undetectable","4blvA-6fhtA:undetectable"],["4CUT_A_TYLA2971_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"VAL A 715;VAL A 711;ASN A 645;ILE A 675","None","1.23A","4cutA-6fhtA:undetectable","4cutA-6fhtA:18.10"],["4FJP_A_NPSA711_1","LACTOTRANSFERRIN","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"GLY A 600;PRO A 602;TYR A 662;GLY A 516","None","0.82A","4fjpA-6fhtA:undetectable","4fjpA-6fhtA:13.04"],["4I89_B_1FLB201_1","TRANSTHYRETIN","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",4,"LYS A  -1;ALA A 182;SER A 206;THR A 183","None","1.08A","4i89B-6fhtA:undetectable","4i89B-6fhtA:23.21"],["4L9Q_B_9TPB601_1","SERUM ALBUMIN","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"LEU A 370;PRO A 348;ALA A 501;LEU A 357;GLY A 361","None","1.22A","4l9qB-6fhtA:undetectable","4l9qB-6fhtA:8.72"],["4XI3_D_29SD601_1","ESTROGEN RECEPTOR","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"ALA A 427;LEU A 395;LEU A 392;ARG A 371;LEU A 408","None","1.30A","4xi3D-6fhtA:undetectable","4xi3D-6fhtA:21.67"],["5IGJ_A_CTYA402_1","MACROLIDE 2'-PHOSPHOTRANSFERASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Deinococcus radiodurans;Synechocystis sp. PCC 6803",5,"ILE A 675;GLU A 648;ALA A 609;VAL A 613;GLY A 600","None","1.10A","5igjA-6fhtA:undetectable","5igjA-6fhtA:11.63"],["5V0I_A_TRPA402_0","TRYPTOPHAN--TRNA LIGASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.34A","5v0iA-6fhtA:undetectable","5v0iA-6fhtA:undetectable"],["5V0I_B_TRPB402_0","TRYPTOPHAN--TRNA LIGASE","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",5,"GLY A 616;GLN A 620;MET A 576;ILE A 580;VAL A 597","None","1.29A","5v0iB-6fhtA:undetectable","5v0iB-6fhtA:undetectable"],["5VKQ_A_PCFA1808_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"LEU A 438;ALA A 427;LEU A 426;LEU A 395","None","0.80A","5vkqA-6fhtA:undetectable;5vkqD-6fhtA:undetectable","5vkqA-6fhtA:undetectable;5vkqD-6fhtA:undetectable"],["5VKQ_B_PCFB1805_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"LEU A 395;LEU A 438;ALA A 427;LEU A 426","None","0.81A","5vkqA-6fhtA:undetectable;5vkqB-6fhtA:undetectable","5vkqA-6fhtA:undetectable;5vkqB-6fhtA:undetectable"],["5VKQ_C_PCFC1806_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"LEU A 395;LEU A 438;ALA A 427;LEU A 426","None","0.78A","5vkqB-6fhtA:undetectable;5vkqC-6fhtA:undetectable","5vkqB-6fhtA:undetectable;5vkqC-6fhtA:undetectable"],["5VKQ_D_PCFD1806_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"LEU A 395;LEU A 438;ALA A 427;LEU A 426","None","0.84A","5vkqC-6fhtA:undetectable;5vkqD-6fhtA:undetectable","5vkqC-6fhtA:undetectable;5vkqD-6fhtA:undetectable"],["6MN4_F_AM2F301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","6fht","BACTERIOPHYTOCHROME,ADENYLATE CYCLASE","Synechocystis sp. PCC 6803;Deinococcus radiodurans",4,"HIS A  38;ARG A 100;GLU A 127;GLU A 306","None","1.35A","6mn4F-6fhtA:undetectable","6mn4F-6fhtA:undetectable"]]