SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 8 ASP A 111
TRP A  87
ARG A  45
THR A 135
 None
 1.18A 1ceaA-6fi2A:
undetectable
1ceaB-6fi2A:
undetectable		 1ceaA-6fi2A:
12.79
1ceaB-6fi2A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 9 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.45A 1iwjA-6fi2A:
undetectable		 1iwjA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 10 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.41A 1o76A-6fi2A:
undetectable		 1o76A-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 9 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.38A 1t86B-6fi2A:
undetectable		 1t86B-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 7 SER A 313
SER A 259
SER A 257
GLN A 231
 None
None
None
DJB  A 503 ( 3.3A)
 1.05A 2cmlA-6fi2A:
undetectable		 2cmlA-6fi2A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 8 SER A 313
SER A 259
SER A 257
GLN A 231
 None
None
None
DJB  A 503 ( 3.3A)
 1.07A 2cmlB-6fi2A:
undetectable		 2cmlB-6fi2A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 8 SER A 313
SER A 259
SER A 257
GLN A 231
 None
None
None
DJB  A 503 ( 3.3A)
 1.15A 2cmlD-6fi2A:
undetectable		 2cmlD-6fi2A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 LEU A 247
ASN A 272
ARG A 379
 None
 0.89A 2qhfA-6fi2A:
undetectable		 2qhfA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 ARG A 172
ASP A 122
ASN A 151
 None
 0.78A 2zzmA-6fi2A:
undetectable		 2zzmA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 6 ASN A 310
SER A 259
ALA A 333
ASP A 330
 None
 1.08A 3aruA-6fi2A:
undetectable		 3aruA-6fi2A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 9 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.47A 3cppA-6fi2A:
undetectable		 3cppA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 5 ASP A 165
ARG A 168
VAL A 196
THR A 147
 None
 1.14A 3eigA-6fi2A:
undetectable		 3eigA-6fi2A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 12 SER A  40
PRO A  36
GLY A 114
ARG A 116
VAL A 117
 None
 1.47A 3jb2A-6fi2A:
undetectable		 3jb2A-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 9 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.43A 4ek1B-6fi2A:
undetectable		 4ek1B-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 12 GLY A 123
LEU A  74
ILE A 139
ASN A 151
LEU A 134
 None
 1.10A 4fr0A-6fi2A:
undetectable		 4fr0A-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 ASP A 314
LYS A 332
LEU A 335
 None
 0.97A 4ptjA-6fi2A:
undetectable		 4ptjA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 12 GLY A 268
ASP A 339
ILE A 270
ALA A 375
HIS A 223
 None
 1.28A 4wh5A-6fi2A:
undetectable		 4wh5A-6fi2A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 8 ALA A 382
HIS A 136
ASN A 384
THR A 389
 None
 1.32A 5db5A-6fi2A:
undetectable
5db5B-6fi2A:
undetectable		 5db5A-6fi2A:
undetectable
5db5B-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 12 TYR A 363
PRO A 234
ASN A 224
LEU A 174
ILE A 185
 None
 1.41A 5dv4A-6fi2A:
undetectable		 5dv4A-6fi2A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 7 PHE A 190
LEU A 248
GLY A 255
TYR A 342
 None
 0.85A 5h3aB-6fi2A:
undetectable		 5h3aB-6fi2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 GLN A 101
THR A 147
ASP A 122
 None
 0.92A 5k9dA-6fi2A:
undetectable		 5k9dA-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 HIS A 136
ASP A 162
HIS A 163
 None
 0.96A 5n1tW-6fi2A:
undetectable		 5n1tW-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6fi2 VEXL
(Achromobacter
denitrificans) 		4 / 6 LEU A 137
ARG A 103
THR A 100
LEU A  98
 None
 1.01A 5x1fA-6fi2A:
undetectable
5x1fJ-6fi2A:
undetectable		 5x1fA-6fi2A:
undetectable
5x1fJ-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 6fi2 VEXL
(Achromobacter
denitrificans) 		5 / 12 ILE A 139
VAL A 161
LEU A 119
THR A 188
LEU A  74
 None
 1.18A 6b54A-6fi2A:
undetectable		 6b54A-6fi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6fi2 VEXL
(Achromobacter
denitrificans) 		3 / 3 THR A 287
GLU A 281
ASN A 292
 None
None
DJE  A 504 ( 4.8A)
 0.88A 6nj9K-6fi2A:
undetectable		 6nj9K-6fi2A:
undetectable