SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A1011
PHE A 860
LEU A 880
PHE A1074
 None
 1.17A 1wrlE-6fj4A:
undetectable		 1wrlE-6fj4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A1039
GLY A1046
PHE A1048
 None
 0.52A 2m2pB-6fj4A:
undetectable		 2m2pB-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A1063
LEU A 880
ARG A1064
ILE A 873
GLY A 979
 None
None
None
None
SEP  A 954 ( 3.9A)
 1.21A 3cv9A-6fj4A:
undetectable		 3cv9A-6fj4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 865
PHE A1011
PHE A1074
PHE A 860
 SEP  A 954 ( 3.7A)
None
None
None
 0.87A 3ko0D-6fj4A:
undetectable
3ko0E-6fj4A:
undetectable		 3ko0D-6fj4A:
17.27
3ko0E-6fj4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 865
PHE A1011
PHE A1074
PHE A 860
 SEP  A 954 ( 3.7A)
None
None
None
 0.76A 3ko0L-6fj4A:
undetectable
3ko0N-6fj4A:
undetectable		 3ko0L-6fj4A:
17.27
3ko0N-6fj4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A 860
GLY A 865
PHE A1011
PHE A1074
 None
SEP  A 954 ( 3.7A)
None
None
 0.90A 3ko0K-6fj4A:
undetectable
3ko0S-6fj4A:
undetectable		 3ko0K-6fj4A:
17.27
3ko0S-6fj4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A 860
GLY A 865
PHE A1011
PHE A1074
 None
SEP  A 954 ( 3.7A)
None
None
 0.76A 3ko0R-6fj4A:
undetectable
3ko0T-6fj4A:
undetectable		 3ko0R-6fj4A:
17.27
3ko0T-6fj4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A1049
ILE A 998
LEU A1003
LYS A1005
 None
 1.30A 3sueC-6fj4A:
undetectable		 3sueC-6fj4A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 4 LEU A 893
ILE A 859
TYR A 973
TYR A 846
 None
 1.33A 3vt7A-6fj4A:
undetectable		 3vt7A-6fj4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 HIS A 886
ILE A 883
TYR A1068
PRO A 816
 CD  A1101 (-3.3A)
None
None
None
 1.10A 4g5jA-6fj4A:
undetectable		 4g5jA-6fj4A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASN A 966
MET A 863
LEU A 958
ILE A 994
 None
 1.06A 4ok1A-6fj4A:
undetectable		 4ok1A-6fj4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASP A 877
VAL A 878
TRP A1060
GLU A 868
 None
 0.88A 4qzuA-6fj4A:
undetectable
4qzuD-6fj4A:
undetectable		 4qzuA-6fj4A:
undetectable
4qzuD-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLU A 916
GLU A 870
TRP A1060
ASP A 877
 None
 1.15A 4uacA-6fj4A:
undetectable		 4uacA-6fj4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 916
GLY A 836
PHE A 913
LEU A 843
PRO A 901
 None
 1.32A 4uinH-6fj4A:
undetectable
4uinL-6fj4A:
undetectable		 4uinH-6fj4A:
undetectable
4uinL-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PHE A1074
GLY A 949
TYR A 973
ALA A 972
 None
 1.25A 4yshB-6fj4A:
undetectable		 4yshB-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 922
PHE A 917
ARG A 948
ILE A 859
 None
 1.03A 4zzcA-6fj4A:
undetectable
4zzcB-6fj4A:
undetectable		 4zzcA-6fj4A:
undetectable
4zzcB-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 890
TYR A 819
CYH A 823
 None
None
CD  A1101 (-2.6A)
 1.02A 5lsuB-6fj4A:
undetectable		 5lsuB-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 873
LEU A 884
VAL A 898
ALA A1013
GLY A1015
 None
 1.14A 5uxdB-6fj4A:
undetectable		 5uxdB-6fj4A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6fj4 ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A1008
HIS A1036
MET A1031
 None
 1.08A 6af6A-6fj4A:
undetectable		 6af6A-6fj4A:
undetectable