SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 5 SER A 186
THR A  94
GLU A 181
GLY A 182
 BOG  A 409 (-2.4A)
BOG  A 409 ( 4.1A)
BOG  A 407 ( 3.0A)
BOG  A 409 ( 3.7A)
 1.21A 1icrA-6fk6A:
undetectable
1icrB-6fk6A:
undetectable		 1icrA-6fk6A:
15.21
1icrB-6fk6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 6 SER A 186
THR A  94
GLU A 181
GLY A 182
 BOG  A 409 (-2.4A)
BOG  A 409 ( 4.1A)
BOG  A 407 ( 3.0A)
BOG  A 409 ( 3.7A)
 1.17A 1icuA-6fk6A:
undetectable
1icuB-6fk6A:
undetectable		 1icuA-6fk6A:
15.21
1icuB-6fk6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 5 SER A 186
THR A  94
GLU A 181
GLY A 182
 BOG  A 409 (-2.4A)
BOG  A 409 ( 4.1A)
BOG  A 407 ( 3.0A)
BOG  A 409 ( 3.7A)
 1.19A 1icvC-6fk6A:
undetectable
1icvD-6fk6A:
undetectable		 1icvC-6fk6A:
15.21
1icvD-6fk6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 5 GLU A 181
GLY A 182
SER A 186
THR A  94
 BOG  A 407 ( 3.0A)
BOG  A 409 ( 3.7A)
BOG  A 409 (-2.4A)
BOG  A 409 ( 4.1A)
 1.18A 1icvC-6fk6A:
undetectable
1icvD-6fk6A:
undetectable		 1icvC-6fk6A:
15.21
1icvD-6fk6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 5 GLU A 181
GLY A 182
SER A 186
THR A  94
 BOG  A 407 ( 3.0A)
BOG  A 409 ( 3.7A)
BOG  A 409 (-2.4A)
BOG  A 409 ( 4.1A)
 1.17A 1kqbA-6fk6A:
undetectable
1kqbB-6fk6A:
undetectable		 1kqbA-6fk6A:
undetectable
1kqbB-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 LEU A  46
VAL A 300
GLY A  51
TYR A  43
 None
 0.94A 1lweA-6fk6A:
undetectable		 1lweA-6fk6A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 8 LEU A  46
VAL A 300
GLY A  51
TYR A  43
 None
 0.97A 1s1xA-6fk6A:
undetectable		 1s1xA-6fk6A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6fk6 RHODOPSIN
(Bos
taurus) 		5 / 12 VAL A 227
ALA A 233
ALA A 234
GLN A 237
VAL A 254
 BOG  A 410 ( 4.9A)
None
None
None
None
 0.76A 3fc6C-6fk6A:
2.3		 3fc6C-6fk6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6fk6 RHODOPSIN
(Bos
taurus) 		5 / 12 PHE A 105
PHE A 103
LEU A  95
THR A  92
GLY A  89
 None
 1.34A 4qb9E-6fk6A:
undetectable		 4qb9E-6fk6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.46A 5a06A-6fk6A:
undetectable		 5a06A-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.49A 5a06C-6fk6A:
undetectable		 5a06C-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.46A 5a06D-6fk6A:
undetectable		 5a06D-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.48A 5a06E-6fk6A:
undetectable		 5a06E-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 7 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.45A 5a06F-6fk6A:
undetectable		 5a06F-6fk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fk6 RHODOPSIN
(Bos
taurus) 		4 / 6 VAL A 157
SER A 127
ARG A 135
ILE A 133
 None
 1.07A 5jw1B-6fk6A:
undetectable		 5jw1B-6fk6A:
8.96