SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 SER D 414
GLU D 415
GLU D 416
 None
 0.57A 1eqbD-6fkhD:
undetectable		 1eqbD-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 SER D 414
GLU D 415
GLU D 416
 None
 0.56A 1eqbB-6fkhD:
undetectable		 1eqbB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR C  60
GLY C  38
THR C 234
ILE C  39
 None
 0.98A 1gtnF-6fkhC:
undetectable
1gtnG-6fkhC:
undetectable		 1gtnF-6fkhC:
undetectable
1gtnG-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 ILE e  69
GLY e  32
ILE e  23
ILE e  76
ILE e  74
 None
 0.86A 1hshB-6fkhe:
undetectable		 1hshB-6fkhe:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 PHE g 168
LEU g 138
TYR g 167
LEU g 213
LEU g 120
 None
 1.39A 1p33A-6fkhg:
3.0		 1p33A-6fkhg:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 ILE C 130
ARG C 301
LEU C 238
PRO C 240
 None
 1.32A 1s8fA-6fkhC:
undetectable
1s8fB-6fkhC:
undetectable		 1s8fA-6fkhC:
undetectable
1s8fB-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 ILE C 116
ILE C 109
LYS C 114
THR C 242
 None
 0.85A 1sbrA-6fkhC:
undetectable		 1sbrA-6fkhC:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 SER C 275
LEU C 277
ILE C  39
THR C 234
 None
 0.91A 1sbrA-6fkhC:
undetectable		 1sbrA-6fkhC:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ILE D 275
GLY D 307
ILE D 313
THR D 342
SER D 303
 None
 1.26A 1sg9A-6fkhD:
undetectable		 1sg9A-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ILE C 184
THR C 183
LEU C 258
VAL C 224
GLN C 201
 None
 0.98A 1tw4A-6fkhC:
undetectable		 1tw4A-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 GLU C 321
THR C 322
LEU C 167
 None
 0.72A 1v8bC-6fkhC:
undetectable		 1v8bC-6fkhC:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ALA C 113
ILE C 109
ILE C  98
PHE C 250
ILE C 259
 None
 0.99A 1xozA-6fkhC:
undetectable		 1xozA-6fkhC:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 PHE D 430
VAL D 449
GLY D 450
ILE D 480
 None
 0.69A 2a1mB-6fkhD:
undetectable		 2a1mB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 8 ASP g 181
LYS g 162
GLY g 164
PHE g 168
TYR g 179
 None
 1.39A 2aouA-6fkhg:
undetectable		 2aouA-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		3 / 3 LYS g  59
ASP C 348
ASP C 171
 None
 0.94A 2br4A-6fkhg:
undetectable		 2br4A-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 LEU C 411
VAL g  67
ALA g  63
LEU g  66
LEU C 403
 None
 1.32A 2c12F-6fkhC:
undetectable		 2c12F-6fkhC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		5 / 12 ASN D 240
TYR C 261
LEU C 305
TYR C 252
ALA C 244
 None
 1.26A 2iyfB-6fkhD:
undetectable		 2iyfB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 SER a  43
VAL a  46
VAL a  39
SER a 108
 None
 1.22A 2j9cA-6fkha:
undetectable
2j9cB-6fkha:
undetectable
2j9cC-6fkha:
undetectable		 2j9cA-6fkha:
undetectable
2j9cB-6fkha:
undetectable
2j9cC-6fkha:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 LEU a 195
GLY a 192
ALA a 141
LEU a 140
PHE a 231
 None
 1.13A 2oz7A-6fkha:
undetectable		 2oz7A-6fkha:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 VAL D 249
THR D 252
VAL D 100
GLY D 115
 None
 1.08A 2p2fA-6fkhD:
undetectable		 2p2fA-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 VAL D 249
THR D 252
VAL D 100
GLY D 115
 None
 1.12A 2p2fB-6fkhD:
undetectable		 2p2fB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		3 / 3 ASN D  71
ARG D  73
ASP C   7
 None
 0.98A 2qe6B-6fkhD:
undetectable		 2qe6B-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 THR g 321
LEU g 220
MET g 320
MET g 136
 None
 1.50A 2vavL-6fkhg:
0.0		 2vavL-6fkhg:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 PHE a 231
VAL a  82
GLY a  99
MET a 101
PHE a  97
 None
 1.46A 2w98A-6fkha:
undetectable		 2w98A-6fkha:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		4 / 5 ARG e 110
ASP g 177
ILE g 158
GLU g 206
 None
 1.50A 2xrzA-6fkhe:
undetectable
2xrzB-6fkhe:
undetectable		 2xrzA-6fkhe:
undetectable
2xrzB-6fkhe:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 THR e  42
ILE e  31
THR e  40
HIS e  37
ILE e  74
 None
 1.28A 2y7wB-6fkhe:
undetectable		 2y7wB-6fkhe:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 THR C 149
GLN C 187
LEU C 317
LEU C 258
 None
 1.19A 3bgdA-6fkhC:
2.7		 3bgdA-6fkhC:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 MET D 247
VAL D  77
GLU D 284
 None
 0.80A 3c6gA-6fkhD:
undetectable		 3c6gA-6fkhD:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6fkh ATP SYNTHASE DELTA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR d 222
VAL d 179
THR d 181
VAL d 212
 None
 0.53A 3em0B-6fkhd:
undetectable		 3em0B-6fkhd:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ASN g 301
LEU g 300
LEU g 230
VAL g 210
ILE g 194
 None
 0.95A 3fl9B-6fkhg:
undetectable		 3fl9B-6fkhg:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ASN g 301
LEU g 300
LEU g 230
VAL g 210
ILE g 194
 None
 0.99A 3fl9G-6fkhg:
undetectable		 3fl9G-6fkhg:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 GLY C 312
THR C 315
GLU C 254
GLU C 102
 None
 1.08A 3fpjA-6fkhC:
2.6		 3fpjA-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 VAL g 226
VAL g 218
ILE g 239
VAL g 247
 None
 0.86A 3hjoB-6fkhg:
undetectable		 3hjoB-6fkhg:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 PRO C 428
LEU C 429
GLN C 423
 None
 0.70A 3hznG-6fkhC:
undetectable
3hznH-6fkhC:
undetectable		 3hznG-6fkhC:
undetectable
3hznH-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLY D 297
GLU D 284
ALA D 281
ASP C 290
ARG D 246
 None
 1.41A 3jzjA-6fkhD:
undetectable		 3jzjA-6fkhD:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 VAL D 176
GLY D 177
VAL C 364
GLN C 342
GLY D 173
 None
 1.42A 3kmoA-6fkhD:
undetectable		 3kmoA-6fkhD:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 0.95A 3ms9A-6fkhg:
undetectable		 3ms9A-6fkhg:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 0.96A 3mssA-6fkhg:
undetectable		 3mssA-6fkhg:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 0.99A 3mssC-6fkhg:
undetectable		 3mssC-6fkhg:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 SER D  99
SER D 130
HIS D 133
 None
 0.80A 3mzeA-6fkhD:
undetectable		 3mzeA-6fkhD:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 PRO C 159
ASP C 155
VAL C 179
ALA C 180
THR C 149
 None
 1.37A 3n23A-6fkhC:
undetectable		 3n23A-6fkhC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 PRO C 159
ASP C 155
VAL C 179
ALA C 180
THR C 149
 None
 1.36A 3n23C-6fkhC:
undetectable		 3n23C-6fkhC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 LYS C 304
ARG C 162
LYS C 377
 None
 1.47A 3okxA-6fkhC:
2.6		 3okxA-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
 None
 1.24A 3olsB-6fkhC:
undetectable		 3olsB-6fkhC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 1.03A 3pyyA-6fkhg:
undetectable		 3pyyA-6fkhg:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 VAL a  75
PHE a 102
PHE a 104
VAL a  46
 None
 1.25A 3rv5C-6fkha:
undetectable
3rv5D-6fkha:
undetectable		 3rv5C-6fkha:
undetectable
3rv5D-6fkha:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 LEU D 269
LEU D 185
ILE D 313
GLN D 310
VAL D 365
 None
 1.27A 3w1wB-6fkhD:
undetectable		 3w1wB-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 GLU D 150
PHE D 149
TYR D 448
VAL D 437
 None
 0.98A 4a97D-6fkhD:
2.3		 4a97D-6fkhD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 GLU D 150
PHE D 149
TYR D 448
VAL D 437
 None
 1.13A 4a97E-6fkhD:
2.4		 4a97E-6fkhD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 MET D 239
GLY D 203
ARG C 165
GLU D 208
 None
 1.42A 4bqfA-6fkhD:
undetectable		 4bqfA-6fkhD:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 LYS D 359
LEU D 356
ALA D 358
 None
 0.73A 4ikiA-6fkhD:
undetectable		 4ikiA-6fkhD:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
 None
 1.20A 4j24C-6fkhC:
undetectable		 4j24C-6fkhC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
 None
 1.15A 4j26B-6fkhC:
undetectable		 4j26B-6fkhC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ALA C 180
ILE C 319
LEU C 298
ILE C 259
THR C 181
 None
 0.96A 4km0B-6fkhC:
undetectable		 4km0B-6fkhC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6fkh ATP SYNTHASE DELTA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 LYS d 101
ASN d 163
ASP d 167
ASP d  98
 None
 1.48A 4o1eB-6fkhd:
undetectable		 4o1eB-6fkhd:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 TYR C 241
ALA C 113
ALA C 245
GLY C 243
LEU C 246
 None
 1.10A 4oaeA-6fkhC:
undetectable		 4oaeA-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLY e  65
VAL e  78
ILE e  46
LEU e  24
LEU e  60
 None
 1.06A 4pd4C-6fkhe:
undetectable		 4pd4C-6fkhe:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 VAL g  72
LEU C 403
ALA g  68
MET g 320
LEU g  66
 None
 1.44A 4qdcA-6fkhg:
undetectable		 4qdcA-6fkhg:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLU D 116
ASN D 112
ALA D 233
PHE D 260
VAL D 198
 None
 1.14A 4u8yB-6fkhD:
undetectable		 4u8yB-6fkhD:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 LEU g 201
LEU g 231
VAL g 210
PHE g 199
 None
 1.23A 4uswA-6fkhg:
undetectable		 4uswA-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ASP D 273
ALA D 326
ASP D 211
GLY D 203
GLY D 209
 None
 1.08A 4xp4A-6fkhD:
undetectable		 4xp4A-6fkhD:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ALA a 147
TYR a 150
PRO a  93
 None
 0.39A 4zdyA-6fkha:
0.7		 4zdyA-6fkha:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE DELTA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		4 / 4 ILE d 161
ARG C   5
TYR d  78
GLU C   8
 None
 1.44A 4zzbD-6fkhd:
undetectable		 4zzbD-6fkhd:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 THR C 183
VAL C 160
GLY C 161
THR C 315
VAL C 192
 None
 1.39A 5cp4A-6fkhC:
undetectable		 5cp4A-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 VAL D 124
GLY D 108
ARG D 109
PHE D 111
 None
 0.95A 5d4nA-6fkhD:
undetectable
5d4nC-6fkhD:
undetectable		 5d4nA-6fkhD:
undetectable
5d4nC-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 PRO C 159
LEU C 383
SER C 369
 None
 0.84A 5fsaB-6fkhC:
undetectable		 5fsaB-6fkhC:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ASP a 179
SER a 145
TYR a 148
 None
 0.78A 5glmA-6fkha:
undetectable		 5glmA-6fkha:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 GLY D 201
ASP D 273
ARG D 277
MET D 306
 None
 1.25A 5gwkA-6fkhD:
undetectable		 5gwkA-6fkhD:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 4 GLN C 148
GLN C 434
PRO C 159
ALA C 156
 None
 1.45A 5odcA-6fkhC:
undetectable
5odcG-6fkhC:
undetectable		 5odcA-6fkhC:
undetectable
5odcG-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 PRO C 159
ALA C 156
GLN C 148
GLN C 434
 None
 1.45A 5odcA-6fkhC:
2.8
5odcG-6fkhC:
3.1		 5odcA-6fkhC:
undetectable
5odcG-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE DELTA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		3 / 3 GLU C  18
HIS d 141
VAL d  85
 None
 0.84A 5trqB-6fkhC:
undetectable		 5trqB-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLY C 175
VAL C 335
THR C 322
PRO C 318
ILE C 358
 ATP  C 602 ( 3.4A)
None
None
None
None
 1.14A 5tuiB-6fkhC:
undetectable		 5tuiB-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 SER C 365
ALA C 371
ALA C 156
ILE C 152
GLY C 150
 None
 0.99A 5veuB-6fkhC:
undetectable		 5veuB-6fkhC:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
(Spinacia
oleracea;
Spinacia
oleracea) 		4 / 6 SER g 324
GLU D 400
ARG D 397
ASP D 417
 None
 1.21A 5zw4A-6fkhg:
undetectable		 5zw4A-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 VAL D  74
LEU D  47
VAL D  91
GLY D  21
VAL D  30
 None
 1.20A 6a94B-6fkhD:
undetectable		 6a94B-6fkhD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 LEU C 387
THR C 437
PRO C 356
ARG C 355
 None
None
ATP  C 602 ( 4.2A)
ATP  C 602 ( 4.1A)
 1.25A 6ew0B-6fkhC:
undetectable		 6ew0B-6fkhC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 LEU C 387
THR C 437
PRO C 356
ARG C 355
 None
None
ATP  C 602 ( 4.2A)
ATP  C 602 ( 4.1A)
 1.25A 6ew0D-6fkhC:
undetectable		 6ew0D-6fkhC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 LEU C 387
THR C 437
PRO C 356
ARG C 355
 None
None
ATP  C 602 ( 4.2A)
ATP  C 602 ( 4.1A)
 1.25A 6ew0H-6fkhC:
undetectable		 6ew0H-6fkhC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 LEU C 387
THR C 437
PRO C 356
ARG C 355
 None
None
ATP  C 602 ( 4.2A)
ATP  C 602 ( 4.1A)
 1.25A 6ew0I-6fkhC:
undetectable		 6ew0I-6fkhC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 LYS a 163
GLY a 162
GLY a 152
GLU a 244
 None
 0.85A 6mdqA-6fkha:
undetectable		 6mdqA-6fkha:
23.26