SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 6fkq NETRIN-1
(Homo
sapiens) 		5 / 9 LEU A 136
ILE A 161
PHE A 220
GLY A 282
PHE A 174
 None
 1.37A 1td7A-6fkqA:
undetectable		 1td7A-6fkqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6fkq NETRIN-1
(Homo
sapiens) 		4 / 6 PHE A 174
ILE A 247
GLY A 283
GLY A 282
 None
 0.81A 2qx6A-6fkqA:
undetectable
2qx6B-6fkqA:
undetectable		 2qx6A-6fkqA:
14.80
2qx6B-6fkqA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 6fkq NETRIN-1
(Homo
sapiens) 		3 / 3 MET A 210
MET A 159
TYR A 272
 SO4  A 510 ( 4.4A)
None
None
 1.39A 4p6xI-6fkqA:
undetectable		 4p6xI-6fkqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6fkq NETRIN-1
(Homo
sapiens) 		5 / 9 VAL A 147
VAL A 276
GLY A 216
LEU A 217
GLN A 150
 None
 1.32A 6czmA-6fkqA:
undetectable
6czmB-6fkqA:
undetectable		 6czmA-6fkqA:
undetectable
6czmB-6fkqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6fkq NETRIN-1
(Homo
sapiens) 		5 / 10 VAL A 147
VAL A 276
GLY A 216
LEU A 217
GLN A 150
 None
 1.18A 6czmE-6fkqA:
undetectable
6czmF-6fkqA:
undetectable		 6czmE-6fkqA:
undetectable
6czmF-6fkqA:
undetectable