SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 GLU C 245
ARG C 215
ILE C 144
ARG C 250
GLU C 246
 None
 1.48A 1l7hA-6fkxC:
undetectable		 1l7hA-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 7 ARG C  21
ASP C  26
GLY C 252
TYR C 253
 None
 1.06A 2f6dA-6fkxC:
undetectable		 2f6dA-6fkxC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 HIS C  91
TYR C 139
ARG C 119
GLY C 120
 None
 1.15A 2i30A-6fkxC:
undetectable		 2i30A-6fkxC:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 7 PHE C  90
LEU C 197
ALA C 165
ALA C 181
 None
 0.85A 2vcvG-6fkxC:
undetectable		 2vcvG-6fkxC:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 LEU C  13
LEU C  12
LEU C   7
LEU C 298
TYR C 296
 None
 1.50A 2w8yB-6fkxC:
undetectable		 2w8yB-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 LEU C 157
ALA C 193
GLY C 189
ASP C 160
ALA C 260
 None
 1.10A 3ou6A-6fkxC:
undetectable		 3ou6A-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 HIS C 304
ASP C 275
ARG C 297
GLY C  92
SER C 185
 None
 0.76A 3sueB-6fkxC:
undetectable		 3sueB-6fkxC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 HIS C 304
ASP C 275
ARG C 297
GLY C  92
SER C 185
 None
 0.84A 3sueD-6fkxC:
undetectable		 3sueD-6fkxC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 HIS C 304
GLU C 305
ASP C 275
SER C 272
 None
 1.41A 4apjA-6fkxC:
undetectable
4apjP-6fkxC:
undetectable		 4apjA-6fkxC:
undetectable
4apjP-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 ARG C  31
ASP C  35
ASP C 150
ARG C 155
 None
 1.35A 4kcnA-6fkxC:
undetectable		 4kcnA-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 ARG C  31
ASP C  35
ASP C 150
ARG C 155
 None
 1.36A 4kcnB-6fkxC:
undetectable		 4kcnB-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 GLU C 245
ARG C 215
SER C 249
ARG C 250
GLU C 246
 None
 1.38A 4mx0A-6fkxC:
undetectable		 4mx0A-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 5 ARG C 215
THR C  19
ASP C 213
TYR C  15
 None
 1.46A 4qwpB-6fkxC:
undetectable		 4qwpB-6fkxC:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 THR C 161
GLY C 189
PRO C 206
ALA C 204
VAL C 256
 None
 1.14A 4rvgA-6fkxC:
undetectable		 4rvgA-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 VAL C  70
CYH C 118
HIS C 156
LEU C 157
 None
 1.34A 5hrqH-6fkxC:
undetectable
5hrqK-6fkxC:
undetectable
5hrqL-6fkxC:
undetectable		 5hrqH-6fkxC:
undetectable
5hrqK-6fkxC:
undetectable
5hrqL-6fkxC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 7 THR C  19
ASP C 255
TYR C  15
TYR C 227
 None
 1.11A 5hwaA-6fkxC:
undetectable		 5hwaA-6fkxC:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 7 TYR C  93
LEU C 190
GLY C 189
PHE C 210
 None
 0.77A 5nooB-6fkxC:
undetectable		 5nooB-6fkxC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 6 TYR C  93
LEU C 190
GLY C 189
PHE C 210
 None
 0.76A 5nooC-6fkxC:
undetectable		 5nooC-6fkxC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		3 / 3 ARG C 200
ARG C 202
ARG C 264
 None
 0.99A 5vcgA-6fkxC:
undetectable		 5vcgA-6fkxC:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		5 / 12 HIS C 304
ASP C 275
ARG C 297
GLY C  92
SER C 185
 None
 0.74A 6c2mC-6fkxC:
undetectable		 6c2mC-6fkxC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 6fkx ACETYL XYLAN
ESTERASE
(metagenome) 		4 / 5 TYR C  93
ASN C 228
TYR C 227
PHE C 210
 None
 1.41A 6h3dA-6fkxC:
undetectable		 6h3dA-6fkxC:
undetectable