SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6fl0 -
(-) 		6 / 12 ILE A  77
ASP A  36
PHE A  42
ILE A 101
LEU A  84
ILE A  66
 None
 1.43A 1ra2A-6fl0A:
undetectable		 1ra2A-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6fl0 -
(-) 		6 / 12 ILE A  77
ASP A  36
PHE A  42
ILE A 101
LEU A  84
ILE A  66
 None
 1.41A 1rb2A-6fl0A:
undetectable		 1rb2A-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6fl0 -
(-) 		3 / 3 GLN A 131
GLU A 121
LYS A 125
 None
 1.19A 3su9A-6fl0A:
undetectable		 3su9A-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 6fl0 -
(-) 		5 / 12 ILE A  62
VAL A 105
TYR A 185
TYR A 102
THR A 159
 None
 1.18A 3vrjA-6fl0A:
undetectable
3vrjC-6fl0A:
undetectable		 3vrjA-6fl0A:
undetectable
3vrjC-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 6fl0 -
(-) 		5 / 11 LEU A  21
ARG A  64
ASP A 113
LEU A 116
LEU A 146
 None
 1.46A 4or0A-6fl0A:
undetectable		 4or0A-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6fl0 -
(-) 		5 / 11 ILE A  77
ASP A  36
PHE A  42
ILE A 101
ILE A  66
 None
 1.37A 4p68A-6fl0A:
undetectable		 4p68A-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6fl0 -
(-) 		5 / 12 ILE A  77
ASP A  36
PHE A  42
ILE A 101
LEU A  84
 None
 1.16A 4qlgA-6fl0A:
undetectable		 4qlgA-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6fl0 -
(-) 		5 / 12 ILE A  77
ASP A  36
PHE A  42
ILE A 101
LEU A  84
 None
 1.19A 4rgcA-6fl0A:
undetectable		 4rgcA-6fl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 6fl0 -
(-) 		5 / 9 ARG A 114
LEU A 188
SER A 144
THR A 148
ILE A 108
 None
 1.31A 4ubsA-6fl0A:
undetectable		 4ubsA-6fl0A:
undetectable