SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25
(Homo
sapiens) 		4 / 7 ALA A 466
TYR A 488
SER A 473
ALA A 479
 None
 1.02A 1k5qA-6flnA:
undetectable
1k5qB-6flnA:
undetectable		 1k5qA-6flnA:
undetectable
1k5qB-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25
(Homo
sapiens) 		3 / 3 ASN A 330
LEU A 329
HIS A 331
 None
 0.82A 2q6fB-6flnA:
undetectable		 2q6fB-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25
(Homo
sapiens) 		3 / 3 TYR A 463
ARG A 494
HIS A 491
 None
 0.97A 4fubA-6flnA:
undetectable		 4fubA-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25
(Homo
sapiens) 		5 / 12 VAL A 579
LEU A 624
PHE A 615
LEU A 502
ALA A 547
 None
 1.42A 4rtbA-6flnA:
undetectable		 4rtbA-6flnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25
(Homo
sapiens) 		5 / 12 MET A 600
GLU A 566
LEU A 569
ILE A 558
CYH A 524
 None
 1.38A 5vlmB-6flnA:
undetectable		 5vlmB-6flnA:
undetectable