SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		4 / 5 PHE A 156
GLY A  72
THR A 163
PHE A  81
 None
 1.22A 1icuC-6fm7A:
undetectable
1icuD-6fm7A:
undetectable		 1icuC-6fm7A:
16.36
1icuD-6fm7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		4 / 5 PHE A 156
GLY A  72
THR A 163
PHE A  81
 None
 1.31A 1icvA-6fm7A:
undetectable
1icvB-6fm7A:
undetectable		 1icvA-6fm7A:
16.36
1icvB-6fm7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		7 / 10 GLY A  61
LEU A 117
GLN A 118
ASN A 150
TYR A 220
THR A 313
GLY A 314
 NXL  A 401 ( 3.9A)
None
NXL  A 401 (-3.3A)
NXL  A 401 (-3.5A)
NXL  A 401 ( 4.7A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
 1.21A 1kvlA-6fm7A:
55.1		 1kvlA-6fm7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		8 / 10 LEU A 117
GLN A 118
TYR A 148
ASN A 150
TYR A 220
LYS A 312
THR A 313
GLY A 314
 None
NXL  A 401 (-3.3A)
NXL  A 401 (-4.1A)
NXL  A 401 (-3.5A)
NXL  A 401 ( 4.7A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
 0.28A 1kvlA-6fm7A:
55.1		 1kvlA-6fm7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 THR A  56
ASN A 338
ILE A  23
LEU A  17
VAL A  14
 None
 1.08A 1r30A-6fm7A:
undetectable		 1r30A-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 THR A  56
ASN A 338
ILE A  23
LEU A  17
VAL A  14
 None
 1.09A 1r30B-6fm7A:
undetectable		 1r30B-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 GLY A 318
GLY A 200
ILE A  60
LEU A 336
ALA A 321
 SO4  A 403 (-3.5A)
None
None
None
None
 1.01A 1v2xA-6fm7A:
undetectable		 1v2xA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 11 THR A 316
GLY A 318
GLY A 200
ILE A  60
LEU A 336
ALA A 321
 None
SO4  A 403 (-3.5A)
None
None
None
None
 1.35A 1x7pA-6fm7A:
undetectable
1x7pB-6fm7A:
undetectable		 1x7pA-6fm7A:
undetectable
1x7pB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.43A 1ymxB-6fm7A:
15.4		 1ymxB-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ALA A 219
GLY A 221
MET A 172
LEU A 177
LEU A 180
 None
 1.00A 2hw2A-6fm7A:
undetectable		 2hw2A-6fm7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 11 THR A 316
GLY A 318
GLY A 200
ILE A  60
LEU A 336
ALA A 321
 None
SO4  A 403 (-3.5A)
None
None
None
None
 1.42A 3dcmX-6fm7A:
undetectable		 3dcmX-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		4 / 6 VAL A  30
MET A 237
ILE A   9
ILE A 333
 None
 0.76A 3gcsA-6fm7A:
undetectable		 3gcsA-6fm7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.52A 3hlwA-6fm7A:
15.4		 3hlwA-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 LYS A  65
ASN A 150
LYS A 312
THR A 313
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.48A 3huoA-6fm7A:
15.5		 3huoA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.49A 3huoB-6fm7A:
15.2		 3huoB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
GLY A 314
THR A 316
ARG A 346
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
None
None
 0.98A 3mzeA-6fm7A:
14.7		 3mzeA-6fm7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
THR A 313
GLY A 314
THR A 316
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
None
 0.68A 3mzeA-6fm7A:
14.7		 3mzeA-6fm7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.55A 3q07A-6fm7A:
15.3		 3q07A-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.52A 3q07B-6fm7A:
15.2		 3q07B-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 9 TYR A  74
THR A 175
LEU A 171
LEU A 164
GLY A 165
 None
 1.28A 4c9kA-6fm7A:
undetectable		 4c9kA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ILE A 222
THR A 185
THR A  70
LEU A 182
LEU A 180
 None
 0.98A 4c9lA-6fm7A:
undetectable		 4c9lA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ILE A 222
THR A 185
THR A  70
LEU A 182
LEU A 180
 None
 0.98A 4c9lB-6fm7A:
undetectable		 4c9lB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 10 TYR A  74
THR A 175
LEU A 171
LEU A 164
GLY A 165
 None
 1.29A 4c9nB-6fm7A:
undetectable		 4c9nB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ILE A 222
THR A 185
THR A  70
LEU A 182
LEU A 180
 None
 1.00A 4c9oA-6fm7A:
undetectable		 4c9oA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ILE A 222
THR A 185
THR A  70
LEU A 182
LEU A 180
 None
 1.00A 4c9oB-6fm7A:
undetectable		 4c9oB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 THR A  68
THR A 316
VAL A 210
ASP A 217
ARG A 169
 None
 1.39A 4i41A-6fm7A:
undetectable		 4i41A-6fm7A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LEU A  71
THR A 175
GLY A  72
VAL A  76
LEU A 171
 None
 1.36A 5jo9A-6fm7A:
undetectable		 5jo9A-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 THR A 316
GLY A 318
GLY A 200
ILE A  60
LEU A 336
ALA A 321
 None
SO4  A 403 (-3.5A)
None
None
None
None
 1.32A 5l0zA-6fm7A:
undetectable		 5l0zA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ASN A 150
LYS A 312
GLY A 314
SER A 315
ASN A 340
 NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
SO4  A 403 (-4.0A)
 0.78A 6c79A-6fm7A:
15.4		 6c79A-6fm7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		4 / 6 PHE A 232
LEU A 180
ALA A 235
THR A  73
 None
 1.00A 6f88A-6fm7A:
undetectable		 6f88A-6fm7A:
23.08