SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.81A 1grmA-6fmlG:
undetectable		 1grmA-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.81A 1grmB-6fmlG:
undetectable		 1grmB-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 TRP G 982
LEU G1133
GLY G 993
LEU G 983
 None
 0.82A 1gtiB-6fmlG:
undetectable		 1gtiB-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 TRP G 982
LEU G1133
GLY G 993
LEU G 983
 None
 0.97A 1gtiD-6fmlG:
undetectable		 1gtiD-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 TRP G 982
LEU G1133
GLY G 993
LEU G 983
 None
 0.81A 1gtiE-6fmlG:
undetectable		 1gtiE-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.94A 1jo4A-6fmlG:
undetectable		 1jo4A-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.94A 1jo4B-6fmlG:
undetectable		 1jo4B-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.95A 1magA-6fmlG:
undetectable		 1magA-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 ALA G1420
VAL G1418
TRP G1415
 None
 0.95A 1magB-6fmlG:
undetectable		 1magB-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 PHE D 296
ALA D 326
ILE D  86
ILE D 356
 None
 0.99A 1oniD-6fmlD:
undetectable
1oniF-6fmlD:
undetectable		 1oniD-6fmlD:
undetectable
1oniF-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 8 LEU D 231
THR D 202
ILE D 162
TYR D 171
 None
 0.94A 1qvtA-6fmlD:
undetectable		 1qvtA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 5 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.05A 1t88B-6fmlD:
undetectable		 1t88B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 ASN G1035
HIS G1034
ILE G1083
TRP G1053
 None
 1.49A 1tdnA-6fmlG:
undetectable		 1tdnA-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 5 GLN G1110
TRP G1036
GLU G1108
LEU G1132
 None
 1.32A 1ulvA-6fmlG:
undetectable		 1ulvA-6fmlG:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.03A 1yrdA-6fmlD:
undetectable		 1yrdA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 5 ILE D 297
ILE D 305
ILE D 108
LEU D 350
 None
 0.94A 1zgyA-6fmlD:
undetectable		 1zgyA-6fmlD:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.08A 2feuA-6fmlD:
undetectable		 2feuA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 5 PHE G1126
LEU G1106
VAL G1027
VAL G1090
 None
 1.21A 2m56A-6fmlG:
undetectable		 2m56A-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 THR D 390
ALA D 387
ARG D 367
PRO D 363
 None
 0.86A 2ql8A-6fmlD:
undetectable
2ql8B-6fmlD:
2.7		 2ql8A-6fmlD:
undetectable
2ql8B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 THR D 390
ALA D 387
ARG D 367
PRO D 363
 None
 0.86A 2ql8A-6fmlD:
undetectable
2ql8B-6fmlD:
2.7		 2ql8A-6fmlD:
undetectable
2ql8B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6fml INO80
(Chaetomium
thermophilum) 		3 / 3 LEU G1222
TYR G1230
GLN G1231
 None
 0.46A 2wekA-6fmlG:
undetectable		 2wekA-6fmlG:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 8 TYR G1646
LEU G1558
ALA G1556
MET G1585
 None
 1.02A 2wekA-6fmlG:
2.4		 2wekA-6fmlG:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.06A 2zawA-6fmlD:
undetectable		 2zawA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.07A 2zaxA-6fmlD:
undetectable		 2zaxA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 11 VAL D  73
VAL D 294
ARG D  71
MET D  62
ILE D  63
 None
 1.25A 2zbzA-6fmlD:
undetectable		 2zbzA-6fmlD:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.04A 2zuhA-6fmlD:
undetectable		 2zuhA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.05A 2zuiA-6fmlD:
undetectable		 2zuiA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.04A 2zwtA-6fmlD:
undetectable		 2zwtA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 9 LEU G1190
ILE G 991
GLY G 993
ILE G 994
ILE G1193
 None
 1.10A 3d1yB-6fmlG:
undetectable		 3d1yB-6fmlG:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 5 ALA G1662
LEU G1626
GLY G1631
THR G1032
 None
 0.95A 3dl9A-6fmlG:
undetectable		 3dl9A-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 9 LEU G1190
ILE G 991
GLY G 993
ILE G 994
ILE G1193
 None
 1.13A 3ekqB-6fmlG:
undetectable		 3ekqB-6fmlG:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6fml INO80
RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 7 LEU G1458
LEU D 259
SER D 251
ASN D 250
THR D 264
 None
 1.43A 3lm8A-6fmlG:
undetectable
3lm8C-6fmlG:
undetectable		 3lm8A-6fmlG:
14.86
3lm8C-6fmlG:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 VAL D  58
SER D  93
ILE D 322
VAL D 294
VAL D  98
 None
 1.20A 3w68A-6fmlD:
4.2		 3w68A-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.09A 3wrhE-6fmlD:
undetectable		 3wrhE-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.08A 3wrjE-6fmlD:
undetectable		 3wrjE-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6fml LES2
RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		3 / 3 ASN H 452
TRP H 450
ASP D 190
 None
 1.22A 4a7tA-6fmlH:
undetectable
4a7tF-6fmlH:
undetectable		 4a7tA-6fmlH:
17.09
4a7tF-6fmlH:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 8 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.02A 4d33A-6fmlD:
undetectable		 4d33A-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.01A 4d33B-6fmlD:
undetectable		 4d33B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 8 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.01A 4d39A-6fmlD:
undetectable		 4d39A-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 SER D 309
ILE D 305
ASN D 312
ASP D 348
 None
 1.09A 4d39B-6fmlD:
undetectable		 4d39B-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.04A 4ek1A-6fmlD:
undetectable		 4ek1A-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 PHE D 349
ALA D 314
LEU D 315
ALA D  91
MET D  88
 None
 1.26A 4fe1A-6fmlD:
undetectable
4fe1J-6fmlD:
undetectable		 4fe1A-6fmlD:
7.44
4fe1J-6fmlD:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.05A 4g3rA-6fmlD:
undetectable		 4g3rA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 6 PHE G1126
LEU G1106
VAL G1027
VAL G1090
 None
 1.16A 4g3rB-6fmlG:
undetectable		 4g3rB-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.05A 4g3rB-6fmlD:
undetectable		 4g3rB-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.08A 4kkyX-6fmlD:
undetectable		 4kkyX-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 12 ASN G 992
CYH G1128
ARG G1129
GLN G1102
ILE G1105
 None
 1.39A 4kukA-6fmlG:
undetectable		 4kukA-6fmlG:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 6 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.04A 4l4cA-6fmlD:
undetectable		 4l4cA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 ARG G1308
VAL G1477
GLU G1312
ARG G1314
 None
 1.23A 4mv7A-6fmlG:
2.3		 4mv7A-6fmlG:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 6fml RUVB-LIKE HELICASE
INO80
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 6 LEU G1458
LEU G1461
ASN D 250
ILE D 246
 None
 0.73A 4ww7A-6fmlG:
undetectable		 4ww7A-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 6fml RUVB-LIKE HELICASE
INO80
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 4 LEU G1456
ILE D 131
HIS D 239
VAL D 241
 None
 1.29A 4xyzA-6fmlG:
undetectable		 4xyzA-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 6 LEU G1599
LEU G1637
ILE G1621
PHE G1615
 None
 1.25A 4y4dA-6fmlG:
undetectable		 4y4dA-6fmlG:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 5 SER D 438
ARG D 399
GLY D 397
THR D  81
 None
ADP  D 501 (-3.6A)
None
None
 1.08A 5btiA-6fmlD:
undetectable
5btiB-6fmlD:
undetectable		 5btiA-6fmlD:
11.46
5btiB-6fmlD:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 5 SER D 438
ARG D 399
GLY D 397
THR D  81
 None
ADP  D 501 (-3.6A)
None
None
 1.02A 5btiC-6fmlD:
undetectable
5btiD-6fmlD:
undetectable		 5btiC-6fmlD:
11.46
5btiD-6fmlD:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 9 SER D  93
GLY D  66
GLU D  61
ILE D 322
ALA D  69
 None
 1.33A 5entC-6fmlD:
undetectable		 5entC-6fmlD:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 6fml IES6
(Chaetomium
thermophilum) 		3 / 3 ILE I 193
MET I 204
ASP I 171
 None
 0.79A 5h2uA-6fmlI:
undetectable		 5h2uA-6fmlI:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 12 VAL G1549
ASP G1272
LEU G1625
LEU G1589
LEU G1574
 None
 1.18A 5hnyB-6fmlG:
undetectable		 5hnyB-6fmlG:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 12 VAL G1673
ALA G1662
VAL G1671
LEU G1565
ILE G1582
 None
 1.08A 5hv1A-6fmlG:
undetectable		 5hv1A-6fmlG:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 4 GLN D 409
VAL D 379
GLU D 377
ILE D 405
 None
 1.26A 5jncA-6fmlD:
undetectable		 5jncA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 9 LEU G1190
ILE G 991
GLY G 993
ILE G 994
ILE G1193
 None
 1.00A 5kqxB-6fmlG:
undetectable		 5kqxB-6fmlG:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 6fml INO80
(Chaetomium
thermophilum) 		5 / 9 LEU G1190
ILE G 991
GLY G 993
ILE G 994
ILE G1193
 None
 1.09A 5kr2D-6fmlG:
undetectable		 5kr2D-6fmlG:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 10 LEU D  30
ILE D  86
ARG D  53
ALA D  52
VAL D  58
 None
 1.29A 5m0oA-6fmlD:
undetectable		 5m0oA-6fmlD:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 8 ILE G1153
ALA G1109
LEU G1134
THR G1135
 None
 0.77A 5og9A-6fmlG:
undetectable		 5og9A-6fmlG:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		4 / 7 PHE D 349
LEU D 303
VAL D 300
VAL D 323
 None
 1.04A 5wk9A-6fmlD:
undetectable		 5wk9A-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 6fml RUVB-LIKE HELICASE
(Chaetomium
thermophilum) 		5 / 12 GLY D  95
VAL D 291
ILE D  86
GLY D  29
ALA D  56
 None
 1.01A 6c2mD-6fmlD:
undetectable		 6c2mD-6fmlD:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6fml INO80
(Chaetomium
thermophilum) 		4 / 7 ARG G1598
TYR G1596
GLU G1586
ASP G1583
 None
 1.19A 6mn5B-6fmlG:
undetectable		 6mn5B-6fmlG:
24.14